INT13286

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 317
Total Number 322
Disease Relevance 71.58
Pain Relevance 65.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ca2) extracellular space (Ca2) lyase activity (Ca2)
response to stress (Ca2) cytoplasm (Ca2)
Anatomy Link Frequency
spikes 30
neurons 27
astrocytes 14
reticulum 14
brain 5
Ca2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 2059 100.00 Very High Very High Very High
qutenza 1744 100.00 Very High Very High Very High
imagery 1354 100.00 Very High Very High Very High
Glutamate 1062 100.00 Very High Very High Very High
dorsal root ganglion 628 100.00 Very High Very High Very High
depression 617 100.00 Very High Very High Very High
tetrodotoxin 531 100.00 Very High Very High Very High
isoflurane 453 100.00 Very High Very High Very High
Glutamate receptor 178 100.00 Very High Very High Very High
Hippocampus 482 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 824 100.00 Very High Very High Very High
Depression 605 100.00 Very High Very High Very High
Channelopathies 24 100.00 Very High Very High Very High
Hypoxia 4062 99.92 Very High Very High Very High
Stress 534 99.80 Very High Very High Very High
Death 424 99.74 Very High Very High Very High
Brain Injury 214 99.68 Very High Very High Very High
Diabetic Cardiomyopathies 209 99.66 Very High Very High Very High
Diabetes Mellitus 813 99.60 Very High Very High Very High
Myocardial Infarction 299 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The perivascular nerve network expresses a Ca2+ receptor that is activated by high extracellular Ca2+ concentrations and causes vasorelaxation in resistance arteries.
Gene_expression (expresses) of Ca2 in nerve
1) Confidence 0.67 Published 2009 Journal Vascul. Pharmacol. Section Abstract Doc Link 19056515 Disease Relevance 0 Pain Relevance 0.07
Anoxia also reduced both sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity and Ca2+ extrusion [probably via plasma membrane Ca2+-ATPase (PMCA)].
Gene_expression (extrusion) of Ca2 in reticulum associated with hypoxia
2) Confidence 0.66 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.76 Pain Relevance 0.09
Acetaminophen at different doses protects brain microsomal Ca2+-ATPase and the antioxidant redox system in rats.
Gene_expression (protects) of Ca2 in brain associated with paracetamol
3) Confidence 0.65 Published 2009 Journal J. Membr. Biol. Section Title Doc Link 19838617 Disease Relevance 0 Pain Relevance 0.55
Western blotting showed that diabetic rats had a reduced expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)2a, with no difference in expression of the Na+/Ca2+ exchanger.
Gene_expression (expression) of Ca2 in reticulum associated with diabetes mellitus
4) Confidence 0.65 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494698 Disease Relevance 1.00 Pain Relevance 0.08
Western blotting showed that diabetic rats had a reduced expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)2a, with no difference in expression of the Na+/Ca2+ exchanger.
Gene_expression (expression) of Ca2 in reticulum associated with diabetes mellitus
5) Confidence 0.65 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2494698 Disease Relevance 1.00 Pain Relevance 0.08
In neither of the cases could a subsequent application of a low dose of UTP trigger Ca2+ oscillations, so confirming that the ER was the source of Ca2+.
Gene_expression (source) of Ca2
6) Confidence 0.62 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0 Pain Relevance 0.07
In the present work, using the loose ligation of the sciatic nerve model, we characterized the time course of the appearance of tactile and cold allodynia and the corresponding spinal expression of the N-type Ca2+ channel alpha(1B)-subunit after nerve ligation.
Gene_expression (expression) of Ca2 in nerve associated with allodynia and sciatic nerve
7) Confidence 0.58 Published 2002 Journal Exp Brain Res Section Abstract Doc Link 12444477 Disease Relevance 0.36 Pain Relevance 0.34
The relative contributions of SERCA versus PMCA to Ca2+ clearance must therefore depend on the conditions in which such measurements are made.
Gene_expression (clearance) of Ca2
8) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.40 Pain Relevance 0
Effects of anoxia on ER Ca2+ stores
Gene_expression (stores) of Ca2 associated with hypoxia
9) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.59 Pain Relevance 0
Effects of anoxia on resting [Ca2+]i in DRG neurons
Gene_expression (resting) of Ca2 in neurons associated with hypoxia
10) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.35 Pain Relevance 0.10
Interactions among the effects of anoxia on Ca2+ clearance, mitochondrial Ca2+ buffering, and ER Ca2+ uptake
Gene_expression (uptake) of Ca2 associated with hypoxia
11) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.48 Pain Relevance 0
Effects of anoxia on Ca2+ clearance
Gene_expression (clearance) of Ca2 associated with hypoxia
12) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.73 Pain Relevance 0
Note that ryanodine did not deplete ER stores of Ca2+ (as evidenced by the observation that after removal of ryanodine, caffeine evoked a large rise in [Ca2+]i, Fig. 4D) but none the less reduced Ca2+ release in response to anoxia.


Gene_expression (stores) of Ca2 associated with hypoxia
13) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.53 Pain Relevance 0
Anoxia also reduced both sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) activity and Ca2+ extrusion [probably via plasma membrane Ca2+-ATPase (PMCA)].
Gene_expression (extrusion) of Ca2 in reticulum associated with hypoxia
14) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Abstract Doc Link PMC2493471 Disease Relevance 0.76 Pain Relevance 0.09
Cytosolic Ca2+ clearance was quantified during this recovery phase as the rate of change in [Ca2+]i measured over a small range of [Ca2+]i between 150 and 200 or 200 and 250 nM (see legend to Fig. 12).
Gene_expression (clearance) of Ca2
15) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.33 Pain Relevance 0
The peak [Ca2+]i attained under these conditions is determined by the rate of voltage-gated Ca2+ influx, Ca2+ efflux, Ca2+ buffering, and Ca2+ uptake by mitochondria.
Gene_expression (buffering) of Ca2
16) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.53 Pain Relevance 0.04
The peak [Ca2+]i attained under these conditions is determined by the rate of voltage-gated Ca2+ influx, Ca2+ efflux, Ca2+ buffering, and Ca2+ uptake by mitochondria.
Gene_expression (buffering) of Ca2
17) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.52 Pain Relevance 0.04
Interactions among the effects of anoxia on Ca2+ clearance, mitochondrial Ca2+ buffering, and ER Ca2+ uptake
Gene_expression (clearance) of Ca2 associated with hypoxia
18) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.48 Pain Relevance 0
Because Ca2+ clearance can occur via the plasma membrane and/or uptake into the ER, we sought to determine which of these pathways was being inhibited by anoxia.
Gene_expression (clearance) of Ca2 in plasma associated with hypoxia
19) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.43 Pain Relevance 0
Anoxia (3 min) reduced this SERCA-mediated Ca2+ clearance to 6.2 nM/s or ?
Gene_expression (clearance) of Ca2 associated with hypoxia
20) Confidence 0.57 Published 2008 Journal Journal of Neurophysiology Section Body Doc Link PMC2493471 Disease Relevance 0.60 Pain Relevance 0

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