INT132860

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 33
Total Number 34
Disease Relevance 14.70
Pain Relevance 6.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (BDNF) cytoplasmic membrane-bounded vesicle (BDNF)
Anatomy Link Frequency
brain 4
neurons 2
nerve 2
neurite 2
chondrocytes 1
BDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 63 100.00 Very High Very High Very High
Nerve growth factor 273 99.96 Very High Very High Very High
Root ganglion neuron 5 99.56 Very High Very High Very High
Osteoarthritis 2 99.00 Very High Very High Very High
depression 235 98.96 Very High Very High Very High
Pain 51 98.20 Very High Very High Very High
Spinal cord 124 96.76 Very High Very High Very High
withdrawal 2 96.76 Very High Very High Very High
Peripheral nerve injury 7 95.48 Very High Very High Very High
Central nervous system 118 94.92 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 168 100.00 Very High Very High Very High
Diabetes Mellitus 65 99.76 Very High Very High Very High
Ganglion Cysts 7 99.36 Very High Very High Very High
Osteoarthritis 3 99.00 Very High Very High Very High
Depression 301 98.96 Very High Very High Very High
Toxicity 29 98.64 Very High Very High Very High
Pain 68 98.20 Very High Very High Very High
Disease 612 98.04 Very High Very High Very High
Cancer 27 97.20 Very High Very High Very High
Necrosis 11 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
That synergistic interactions between RA and neurotrophins take place
neurotrophin Binding (interactions) of associated with rheumatoid arthritis
1) Confidence 0.47 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.20 Pain Relevance 0.22
Slides were then incubated for 1 hour with rabbit antibody to tyrosine kinase receptor B (BDNF receptor, batch number Rb68-010906-WS; Biosensis, Flagstaff Hill, Australia) at a 1:500 dilution.
BDNF receptor Binding (tyrosine) of
2) Confidence 0.37 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0 Pain Relevance 0
As an example, it has been shown that different BDNF promoters contain multiple sites for various transcription factors (i.e.
BDNF Binding (example) of
3) Confidence 0.37 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.16 Pain Relevance 0.24
Recently, low levels of BDNF has also been associated with diabetes [41].
BDNF Binding (associated) of associated with diabetes mellitus and bdmf
4) Confidence 0.36 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.65 Pain Relevance 0.54
However, TrkB is downregulated following the binding of BDNF [45].
BDNF Binding (binding) of associated with bdmf
5) Confidence 0.36 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.70 Pain Relevance 0.60
Although modules 1 and 2 have upregulated genes, genes associated with BDNF are located only in module 1.
BDNF Binding (associated) of associated with bdmf
6) Confidence 0.36 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.85 Pain Relevance 0.26
Studies investigating a role for neurotrophins in the pathogenesis of osteoarthritis have shown upregulation of both NGF and Trk-A in osteoarthritic chondrocytes [15].
neurotrophin Binding (role) of in chondrocytes associated with nerve growth factor and osteoarthritis
7) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.37 Pain Relevance 0.46
NGF (nerve growth factor), BDNF (brain-derived neurotrophic factor), NT-3 (neurotrophin-3) and NT-4 (neurotrophin-4) also mediate additional higher-order activities, such as learning, memory and behaviour, in addition to their established functions for cell survival.
BDNF Binding (mediate) of in nerve associated with nerve growth factor
8) Confidence 0.36 Published 2006 Journal Clin. Sci. Section Abstract Doc Link 16411893 Disease Relevance 0.47 Pain Relevance 0.11
assay, RA enhanced neurite outgrowth under the condition that the neurotrophin
neurotrophin Binding (condition) of in neurite associated with rheumatoid arthritis
9) Confidence 0.36 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.63 Pain Relevance 0.23
neurotrophin-independent RA/RAR?
neurotrophin Binding (independent) of associated with rheumatoid arthritis
10) Confidence 0.36 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.85 Pain Relevance 0.12
Finally, p75NTR receptor has been found to directly interact with RhoA, a member of the Ras-GTP binding proteins and a regulator of actin assembly in many cell types, suggesting a role for this receptor in the neurite outgrowth and reorganization of the actin cytoscheleton, a function that is negatively modulated by neurotrophin binding [168].


neurotrophin Binding (binding) of in neurite
11) Confidence 0.36 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.17 Pain Relevance 0.03
In addition to NGF, BDNF has recognized neuroprotective effects [21].
BDNF Binding (recognized) of associated with nerve growth factor
12) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575628 Disease Relevance 0.62 Pain Relevance 0.67
The role of neurotrophins in directing brain growth and neuronal functioning is being increasingly recognized.
neurotrophin Binding (recognized) of in brain
13) Confidence 0.35 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.85 Pain Relevance 0.44
The interaction of neurotrophins with the Trk receptors is specific: NGF binds with TrkA, BDNF and NT 4 both bind with TrkB, and NT 3 binds with the highest affinity to TrkC but is also capable of signaling through TrkA and TrkB.
neurotrophin Binding (interaction) of associated with nerve growth factor
14) Confidence 0.35 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.14 Pain Relevance 0.20
All neurotrophins bind p75NTR with similar affinity (Kd~10-9 M), but binding to the Trk receptors is more selective.
neurotrophin Binding (bind) of
15) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.17 Pain Relevance 0.24
TrkB is a membrane-bound neurotrophin receptor that phosphorylates itself, and members of the MAPK pathway, after binding of its ligand; the brain-derived neurotrophin (Bdnf) [28], [29].
neurotrophin Binding (binding) of in brain
16) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2734986 Disease Relevance 0.49 Pain Relevance 0
The neurotrophins bind two classes of receptor, the common p75NTR, which is a member of the tumor necrosis factor receptor family [2,3], and the tropomyosin-related kinase (Trk) receptors, members of the large tyrosine kinase receptor family [4].
neurotrophin Binding (bind) of associated with necrosis and cancer
17) Confidence 0.35 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.19 Pain Relevance 0.15
To demonstrate this strategy, Barati et al. (52) conjugated an antibody that binds to the p75NTR neurotrophin receptor (MC192) to PLL-based polyplexes and demonstrated transgene expression in targeted neurons in models of peripheral nerve injury.
neurotrophin Binding (binds) of in neurons associated with nervous system injury and peripheral nerve injury
18) Confidence 0.35 Published 2007 Journal Pharm Res Section Body Doc Link PMC2292496 Disease Relevance 0.50 Pain Relevance 0.12
The interactions with neurotrophins are complex and frequently reciprocal.
neurotrophin Binding (interactions) of
19) Confidence 0.35 Published 2008 Journal Novartis Found. Symp. Section Abstract Doc Link 18497106 Disease Relevance 0.85 Pain Relevance 0.66
Human BDNF exon VIIIh, which is not linked to a separate promoter, is also not present in rodent BDNF.
BDNF Neg (not) Binding (linked) of
20) Confidence 0.33 Published 2007 Journal Genomics Section Body Doc Link PMC2568880 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox