INT132862

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 4.05
Pain Relevance 3.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ngf, Bdnf) signal transduction (Ngf) extracellular space (Ngf)
aging (Ngf) cytoplasmic membrane-bounded vesicle (Bdnf) molecular_function (Ngf)
Anatomy Link Frequency
spinal cord 1
ganglion 1
Ngf (Rattus norvegicus)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bDMF 136 100.00 Very High Very High Very High
Nerve growth factor 24 100.00 Very High Very High Very High
Inflammation 9 100.00 Very High Very High Very High
Spinal cord 40 99.36 Very High Very High Very High
dorsal root ganglion 5 98.76 Very High Very High Very High
Pain 37 98.36 Very High Very High Very High
nMDA receptor 5 96.16 Very High Very High Very High
IPN 9 94.44 High High
Stimulus evoked pain 18 92.64 High High
antagonist 6 88.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 11 100.00 Very High Very High Very High
Ganglion Cysts 6 98.76 Very High Very High Very High
Pain 55 98.36 Very High Very High Very High
Asthma 3 98.22 Very High Very High Very High
Disease 9 97.68 Very High Very High Very High
Inflammatory Pain 9 94.44 High High
Hypersensitivity 18 92.64 High High
Drug Dependence 1 81.12 Quite High
Depression 2 80.28 Quite High
Neuropathic Pain 30 79.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Total BDNF mRNA was increased by inflammation in vivo and by NGF in vitro.
NGF Positive_regulation (increased) of BDNF associated with nerve growth factor and inflammation
1) Confidence 0.46 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17764660 Disease Relevance 0.71 Pain Relevance 0.66
Given that the increased NGF in response to peripheral inflammation could induce the upregulation of BDNF in the DRG and spinal cord, which subsequently phosphorylated the downstream signals including NMDA receptor subunit NR1, tropomyosine receptor kinase B (TrkB) and extracellular regulating kinase (ERK) [15,16], it is possible that BDNF is also associated with the incision-evoked pain hypersensitivity.
NGF Positive_regulation (upregulation) of BDNF in spinal cord associated with inflammation, nerve growth factor, nmda receptor, hypersensitivity, stimulus evoked pain, bdmf and spinal cord
2) Confidence 0.37 Published 2008 Journal Mol Pain Section Body Doc Link PMC2492846 Disease Relevance 1.67 Pain Relevance 1.99
Both pain and asthma show an underlying pathophysiology linked to increases in endogenous NGF and subsequent NGF-dependent increase in BDNF.
NGF Positive_regulation (increase) of BDNF associated with asthma and pain
3) Confidence 0.23 Published 2006 Journal Clin. Sci. Section Abstract Doc Link 16411894 Disease Relevance 1.10 Pain Relevance 0.42
Y1036 prevents both BDNF- and NGF-mediated trk activation, downstream activation of the p44/42 mitogen-activated protein kinase pathway, and neurotrophin-mediated differentiation of dorsal-root ganglion sensory neurons.
NGF Positive_regulation (activation) of BDNF in ganglion associated with ganglion cysts and nerve growth factor
4) Confidence 0.05 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19923440 Disease Relevance 0.57 Pain Relevance 0.58

General Comments

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