INT132864

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Context Info
Confidence 0.46
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 2.34
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Htt) endoplasmic reticulum (Htt) mitochondrion organization (Htt)
embryo development (Htt) protein complex (Htt) cytoplasm (Htt)
Anatomy Link Frequency
neuronal 4
brain 2
poly 1
vesicles 1
neuropil 1
Htt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 100.00 Very High Very High Very High
Morphine 1 100.00 Very High Very High Very High
adenocard 1 85.76 High High
imagery 63 77.60 Quite High
gABA 2 61.04 Quite High
Enkephalin 1 60.24 Quite High
depression 18 60.08 Quite High
headache 7 50.00 Quite Low
Substantia nigra 1 38.40 Quite Low
Hippocampus 20 16.20 Low Low
Disease Link Frequency Relevance Heat
Headache 4 98.76 Very High Very High Very High
Disease Progression 2 97.48 Very High Very High Very High
Toxicity 26 97.12 Very High Very High Very High
Disease 242 94.08 High High
General Immunology 10 91.72 High High
Huntington's Chorea 73 88.72 High High
Chorea 34 86.40 High High
Mental Disorders 1 75.80 Quite High
Cognitive Disorder 12 74.32 Quite High
Dyskinesias 6 72.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To confirm the interaction of Htt and dynein and extend the analysis to BDNF mRNA, we carried out nick-translation of the BDNF coding sequence DNA in order to detect BDNF mRNA in rat brain sections.
Htt Binding (interaction) of in brain
1) Confidence 0.46 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
Previous investigations indicated that Htt and dynein subunits directly interact [22,23], and that Htt plays a critical role in the transport of intracellular vesicles and proteins [24].
Htt Binding (interact) of in vesicles
2) Confidence 0.46 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
In line with this, neuropil polyQ aggregates have been shown to be strongly correlated with disease progression [31], [32] and intimately associated with axonal degenerative processes [19], a hypothesis consistent with observations that Htt interacts with numerous proteins associated with cytoskeleton-based transport, such as HAP-1 [35]–[38].
Htt Binding (interacts) of in neuropil associated with disease progression
3) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645678 Disease Relevance 0.38 Pain Relevance 0
Association of different susceptibilities to morphine with the expression of 5-HTT and 5-HT1AR mRNA in brain regions of SD rats.
HTT Binding (Association) of in brain associated with morphine
4) Confidence 0.36 Published 2008 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Title Doc Link 18812655 Disease Relevance 0 Pain Relevance 0.10
The 3D temporal and spatial relationship and the co-localization of individual BDNF mRNA-containing granules with Htt and CPEB1 in vibratome sections were demonstrated by high-resolution reconstruction (Fig. 5c and additional file 3).
Htt Binding (granules) of
5) Confidence 0.36 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
To extend these findings, the expression of BDNF mRNA was analyzed with Htt and CPEB1, a protein responsible for recognition of cytoplasmic polyadenylation elements (CPEs) and regulating poly (A) length.
Htt Binding (recognition) of in poly
6) Confidence 0.36 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
We recently reported that Htt associates with components of neuronal RNA granules and contributes to transport of mRNA in dendrites [10].
Htt Binding (associates) of in neuronal
7) Confidence 0.34 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.17 Pain Relevance 0
These results suggest that Htt may play a role in post-transcriptional transport/targeting of mRNA through association with neuronal RNA granules.
Htt Binding (association) of in neuronal
8) Confidence 0.34 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
The discovery that BDNF mRNA is associated with Ago2 and Htt suggests a new mechanism for BDNF gene expression mediated through mRNA processing in neuronal granules.
Htt Binding (associated) of in neuronal
9) Confidence 0.34 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.06 Pain Relevance 0.03
These results suggest that Htt may play a role in post-transcriptional transport/targeting of mRNA through association with neuronal RNA granules.
Htt Binding (association) of in neuronal
10) Confidence 0.34 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0 Pain Relevance 0
CONCLUSION: While the pathophysiology of HDH is unknown, to diagnose patients with HDH or other possible HD-related headaches remains a challenge.


HDH Binding (diagnose) of
11) Confidence 0.32 Published 2009 Journal Arq Neuropsiquiatr Section Body Doc Link 20069204 Disease Relevance 0.06 Pain Relevance 0
-Htt (Millipore), followed by Alexa 488-conjugated goat ?
Htt Binding (conjugated) of
12) Confidence 0.31 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2889995 Disease Relevance 0.20 Pain Relevance 0.03
Recent evidence suggests that the interaction of the group 1 metabotropic glutamate receptors and htt protein may be at the root of delayed onset.4
htt Binding (interaction) of associated with glutamate receptor
13) Confidence 0.30 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2951749 Disease Relevance 1.21 Pain Relevance 0.18
BACKGROUND: HDH has been recognized for many years, but the pathophysiology of this condition is not known.
HDH Binding (recognized) of
14) Confidence 0.30 Published 2006 Journal Headache Section Body Doc Link 16412150 Disease Relevance 0.10 Pain Relevance 0
We recently showed that wild-type Htt is associated with the Argonaute 2 microRNA-processing enzyme involved in gene silencing.
wild-type Htt Binding (associated) of
15) Confidence 0.30 Published 2010 Journal Mol Neurodegener Section Abstract Doc Link PMC2889995 Disease Relevance 0.17 Pain Relevance 0.04

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