INT132881

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 4.35
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INPP5K) endoplasmic reticulum (INPP5K) plasma membrane (INPP5K)
nucleus (INPP5K) cytoplasm (INPP5K)
Anatomy Link Frequency
bladders 3
domes 1
INPP5K (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 47 84.12 Quite High
Pain 14 83.48 Quite High
tolerance 3 60.92 Quite High
Inflammatory response 4 60.40 Quite High
interstitial cystitis 6 50.00 Quite Low
cINOD 6 27.92 Quite Low
Piles 12 24.00 Low Low
Multiple sclerosis 3 5.68 Low Low
Osteoarthritis 5 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 41 100.00 Very High Very High Very High
Inflammatory Bowel Disease 144 98.96 Very High Very High Very High
Disease 56 96.56 Very High Very High Very High
Granuloma 6 92.68 High High
Frailty 33 88.72 High High
Interstitial Cystitis 6 85.56 High High
Fatigue 19 85.48 High High
INFLAMMATION 48 84.08 Quite High
Arthralgia 4 83.48 Quite High
Muscle Weakness 8 82.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Both biotinylated and radiolabeled PPS and heparin bound very weakly or not at all to human and rabbit bladders.
PPS Binding (bound) of in bladders
1) Confidence 0.48 Published 2006 Journal Urology Section Body Doc Link 16413377 Disease Relevance 0.08 Pain Relevance 0
Of note, all 6 of these patients had abnormal features within the PPs on magnified endoscopy; this suggests an association between PPs and the occurrence of ileal lesions in UC patients.
PPs Binding (association) of associated with inflammatory bowel disease
2) Confidence 0.48 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 0.98 Pain Relevance 0.08
The unmodified and modified PPS and heparin, as well as various mucin glycoproteins, were radiolabeled or biotinylated and examined for their ability to bind to rabbit and human bladder.
PPS Spec (examined) Binding (bind) of in bladder
3) Confidence 0.42 Published 2006 Journal Urology Section Body Doc Link 16413377 Disease Relevance 0.09 Pain Relevance 0
However, scant attention has been paid to the association of PPs with the pathogenesis of UC.
PPs Binding (association) of associated with inflammatory bowel disease
4) Confidence 0.42 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 1.31 Pain Relevance 0.16
Our experience indicates that target biopsy under magnifying endoscopy and chromoendoscopy is beneficial for accurate biopsy sampling to obtain M cells, because this allows us to clearly recognize the FAE located on the PPs’ domes.
PPs Binding (recognize) of in domes
5) Confidence 0.32 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831089 Disease Relevance 0.49 Pain Relevance 0
In contrast, the PPS and heparin modified by attachment of lactose, as well as the asialo mucin glycoproteins, bound strongly to human and rabbit bladders.
PPS Binding (bound) of in bladders
6) Confidence 0.31 Published 2006 Journal Urology Section Body Doc Link 16413377 Disease Relevance 0.07 Pain Relevance 0
Several authors have proposed diagnostic criteria for PPS,5,16,17 where the March of Dimes (MoD) criteria seem to be more and more universally accepted.
PPS Binding (criteria) of associated with syndrome
7) Confidence 0.29 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2909497 Disease Relevance 1.26 Pain Relevance 0.08
DS, which has a similar charge density and molecular weight to PPS, strongly inhibited PG synthesis by MPC at all concentrations > 1 ?
PPS Binding (weight) of
8) Confidence 0.25 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.08 Pain Relevance 0

General Comments

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