INT132883

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Context Info
Confidence 0.75
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.96
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Slc11a2) transport (Slc11a2) plasma membrane (Slc11a2)
nucleus (Slc11a2) vacuole (Slc11a2) lysosome (Slc11a2)
Anatomy Link Frequency
enterocyte 1
choroid plexus 1
Slc11a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 2 99.30 Very High Very High Very High
agonist 3 98.88 Very High Very High Very High
narcan 2 94.24 High High
Central nervous system 46 89.56 High High
MU agonist 1 84.36 Quite High
Enkephalin 1 82.00 Quite High
cytokine 3 80.00 Quite High
Inflammation 24 72.08 Quite High
opioid receptor 1 69.36 Quite High
abdominal pain 1 41.48 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 138 99.60 Very High Very High Very High
Diabetes Mellitus 22 97.24 Very High Very High Very High
Obesity 66 96.72 Very High Very High Very High
Cancer 52 88.60 High High
Liver Cancer 22 88.08 High High
Hypoxia 5 86.16 High High
Dislocations 4 85.68 High High
Anaemia 57 85.44 High High
Chronic Renal Failure 62 82.96 Quite High
Iron Overload 6 73.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Strikingly, expression of DMT1, FPN, ceruloplasmin (Cp), and hephaestin were higher in the choroid plexus on in situ hybridization than virtually all other brain regions (Figs. 3, 4, 5, 6 and 7).
Gene_expression (expression) of DMT1 in choroid plexus
1) Confidence 0.75 Published 2009 Journal Metab Brain Dis Section Body Doc Link PMC2788140 Disease Relevance 0 Pain Relevance 0.08
We analyzed expression patterns of iron transporters that were identified originally in the duodenal mucosa, including the apical transporter DMT1, the ferric reductase, Dcytb, the basolateral exporter ferroportin, and the membrane bound ferroxidase hephaestin.
Spec (analyzed) Gene_expression (expression) of DMT1
2) Confidence 0.65 Published 2009 Journal Metab Brain Dis Section Body Doc Link PMC2788140 Disease Relevance 0 Pain Relevance 0.10
The expression of both Dcytb and DMT1 is strongly affected by the iron concentration within the enterocyte.
Gene_expression (expression) of DMT1 in enterocyte
3) Confidence 0.19 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC1805051 Disease Relevance 1.09 Pain Relevance 0.14
The level of agouti mRNA expression in lethal yellow mice was assigned the value of 1.0, and the expression levels in viable yellow mice and transgenic mice were normalized relative to this value.


Gene_expression (expression) of viable yellow associated with targeted disruption
4) Confidence 0.09 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 0.55 Pain Relevance 0
Viable yellow mice express the agouti gene in a ubiquitous manner, but exhibit a wide range in the level of expression of the gene and the associated phenotypes.
Gene_expression (express) of Viable yellow
5) Confidence 0.08 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.31 Pain Relevance 0
DAMGO and DAMGA were full agonist prototypes, morphine, endomorphin-1, endomorphin-1-ol, Dmt-endomorphin-1, endomorphin-2-ol and (D-Met2)-endomorphin-2 were found by both methods to be partial agonists whereas the parameters for normorphine, morphiceptin and endomorphin-2 were intermediate.
Gene_expression (found) of Dmt-endomorphin-1 associated with agonist and morphine
6) Confidence 0.05 Published 2006 Journal Peptides Section Abstract Doc Link 16413634 Disease Relevance 0 Pain Relevance 0.57

General Comments

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