INT132887

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.73
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
glial cells 2
dorsal horn 2
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 9 100.00 Very High Very High Very High
Cancer pain 17 99.92 Very High Very High Very High
Morphine 77 99.70 Very High Very High Very High
Dorsal horn 4 99.68 Very High Very High Very High
Pain 13 98.04 Very High Very High Very High
Thermal hyperalgesia 2 94.60 High High
long-term potentiation 1 92.56 High High
antagonist 10 89.36 High High
Hyperalgesia 7 87.84 High High
opioid receptor 84 86.72 High High
Disease Link Frequency Relevance Heat
Bone Cancer 41 99.82 Very High Very High Very High
Pain 17 98.04 Very High Very High Very High
Hyperalgesia 9 94.60 High High
Nociception 11 85.60 High High
Neuropathic Pain 10 82.32 Quite High
Targeted Disruption 3 82.16 Quite High
INFLAMMATION 8 75.00 Quite High
Inflammatory Pain 1 73.28 Quite High
Cancer 74 62.68 Quite High
Urological Neuroanatomy 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Formalin-induced pain behavior was attenuated in the second phase, and this correlated with abolition of NMDA receptor NR1 Ser896/897 phosphorylation and ERK1 and ERK2 activation in the dorsal horn; AMPA receptor phosphorylation (GluR1/Ser831) was unaffected.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of NR1 in dorsal horn associated with pain, nmda receptor and dorsal horn
1) Confidence 0.49 Published 2006 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 16413788 Disease Relevance 1.01 Pain Relevance 1.18
released from glial cells is reported to facilitate bone cancer pain by enhancing phosphorylation of NMDA receptor NR-1 subunit [33].
Positive_regulation (enhancing) of Phosphorylation (phosphorylation) of NMDA receptor NR-1 subunit in glial cells associated with cancer pain, nmda receptor and bone cancer
2) Confidence 0.41 Published 2010 Journal Mol Pain Section Body Doc Link PMC3020802 Disease Relevance 0.71 Pain Relevance 0.63
Again, administration of LNNA or naltrindole before morphine prevented the phosphorylation of NMDAR subunits and the activation of CaMKII as well (Fig. 4).
Positive_regulation (activation) of Phosphorylation (phosphorylation) of NMDAR associated with morphine
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.26

General Comments

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