INT132888

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.18
Pain Relevance 3.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin1) plasma membrane (Grin1) enzyme binding (Grin1)
cytoplasm (Grin1)
Anatomy Link Frequency
dorsal horn 2
Grin1 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 8 100.00 Very High Very High Very High
Morphine 86 99.98 Very High Very High Very High
Pain 3 98.58 Very High Very High Very High
Dorsal horn 3 98.52 Very High Very High Very High
Thermal hyperalgesia 2 95.68 Very High Very High Very High
antagonist 11 93.80 High High
Kinase C 40 86.64 High High
Hyperalgesia 2 85.52 High High
opioid receptor 84 84.48 Quite High
Neuropathic pain 3 80.00 Quite High
Disease Link Frequency Relevance Heat
Reperfusion Injury 1 98.60 Very High Very High Very High
Pain 5 98.58 Very High Very High Very High
Hyperalgesia 4 95.68 Very High Very High Very High
Nociception 8 86.68 High High
Targeted Disruption 3 83.24 Quite High
Neuropathic Pain 3 80.00 Quite High
INFLAMMATION 1 75.00 Quite High
Inflammatory Pain 1 70.96 Quite High
Injury 2 69.80 Quite High
Urological Neuroanatomy 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine pretreatment significantly inhibited nPKCepsilon membrane translocation and phosphorylation of NR1 subunits of NMDA receptors during reperfusion injury.
Negative_regulation (inhibited) of Phosphorylation (phosphorylation) of NR1 associated with reperfusion injury, nmda receptor and morphine
1) Confidence 0.57 Published 2006 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 16628065 Disease Relevance 0.17 Pain Relevance 1.00
Formalin-induced pain behavior was attenuated in the second phase, and this correlated with abolition of NMDA receptor NR1 Ser896/897 phosphorylation and ERK1 and ERK2 activation in the dorsal horn; AMPA receptor phosphorylation (GluR1/Ser831) was unaffected.
Negative_regulation (abolition) of Phosphorylation (phosphorylation) of NR1 in dorsal horn associated with pain, nmda receptor and dorsal horn
2) Confidence 0.41 Published 2006 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 16413788 Disease Relevance 1.01 Pain Relevance 1.17
Again, administration of LNNA or naltrindole before morphine prevented the phosphorylation of NMDAR subunits and the activation of CaMKII as well (Fig. 4).
Negative_regulation (prevented) of Phosphorylation (phosphorylation) of NMDAR associated with morphine
3) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890584 Disease Relevance 0 Pain Relevance 1.26

General Comments

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