INT132891

Context Info Confidence 0.01 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.47 Pain Relevance 1.58

cytosol (CHUK) nucleolus (CHUK) nucleus (CHUK) cytoplasm (CHUK)

CHUK (Homo sapiens)

Pain Link Frequency Relevance Heat fluoxetine 16 100.00 cytokine 2 96.64 antidepressant 4 83.96 Inflammatory response 2 79.88

Disease Link Frequency Relevance Heat Necrosis 2 98.24 Cancer 2 97.88 INFLAMMATION 2 79.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We next conducted electophoretic mobility shift assay (EMSA) to determine the DNA binding activity of nuclear factor kappa B (Nfkappab), an important upstream modulator for Nos2 expression, to find that fluoxetine increased DNA binding activity of Nfkappab.

Gene_expression (expression) of Nfkappab associated with fluoxetine

1) Confidence 0.01 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.21 Pain Relevance 0.79

The expressions of both Il6 and Tnfalpha by fluoxetine treatment were similar to those of Nos2 and Nfkappab.

Gene_expression (expressions) of Nfkappab associated with fluoxetine

2) Confidence 0.00 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.25 Pain Relevance 0.79

General Comments

This test has worked.