INT132892

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Context Info
Confidence 0.08
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.62
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CHUK) nucleolus (CHUK) nucleus (CHUK)
cytoplasm (CHUK)
CHUK (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 16 99.98 Very High Very High Very High
Inflammation 6 97.24 Very High Very High Very High
cytokine 4 94.00 High High
antidepressant 4 80.44 Quite High
Inflammatory response 2 76.36 Quite High
cINOD 2 66.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 97.24 Very High Very High Very High
Cancer 2 91.20 High High
Necrosis 2 90.72 High High
Stress 6 75.00 Quite High
Adhesions 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the two catalytic subunits of IKK (IKKalpha and IKKbeta), low concentrations of NAC and mito-Q activated IKKalpha activity, thereby inhibiting the downstream NF-kappaB and ICAM-1 induction by TNF-alpha.
Positive_regulation (activated) of IKKalpha
1) Confidence 0.08 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.57 Pain Relevance 0.21
Of the two catalytic subunits of IKK (IKKalpha and IKKbeta), low concentrations of NAC and mito-Q activated IKKalpha activity, thereby inhibiting the downstream NF-kappaB and ICAM-1 induction by TNF-alpha.
Positive_regulation (activated) of IKKalpha
2) Confidence 0.06 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.58 Pain Relevance 0.21
We next conducted electophoretic mobility shift assay (EMSA) to determine the DNA binding activity of nuclear factor kappa B (Nfkappab), an important upstream modulator for Nos2 expression, to find that fluoxetine increased DNA binding activity of Nfkappab.
Positive_regulation (increased) of Nfkappab associated with fluoxetine
3) Confidence 0.00 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.22 Pain Relevance 0.79
By Western blot analysis, phosphorylation levels of p38 mitogen-activated protein kinase (p38 Mapk, Mapk14) and extracellular signal-related kinase (Erk)1/2 Mapk, upstream signaling mediators of Nfkappab were found to be increased by fluoxetine.
Positive_regulation (increased) of Nfkappab associated with fluoxetine
4) Confidence 0.00 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16413968 Disease Relevance 0.25 Pain Relevance 0.80

General Comments

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