INT13290

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.18
First Reported 1981
Last Reported 2006
Negated 1
Speculated 1
Reported most in Abstract
Documents 34
Total Number 35
Disease Relevance 1.86
Pain Relevance 28.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Atxn2l) biological_process (Atxn2l)
Anatomy Link Frequency
brain 12
medulla 1
pons 1
Atxn2l (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 125 100.00 Very High Very High Very High
opioid receptor 116 100.00 Very High Very High Very High
agonist 51 100.00 Very High Very High Very High
Morphine 37 100.00 Very High Very High Very High
Opioid 30 100.00 Very High Very High Very High
mu opioid receptor 20 100.00 Very High Very High Very High
cocaine 17 100.00 Very High Very High Very High
tolerance 14 100.00 Very High Very High Very High
Delta opioid receptors 13 100.00 Very High Very High Very High
Dynorphin 11 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sprains And Strains 4 98.68 Very High Very High Very High
Diabetes Mellitus 4 97.92 Very High Very High Very High
Tics 1 97.60 Very High Very High Very High
Obesity 2 97.56 Very High Very High Very High
Targeted Disruption 14 94.96 High High
Urological Neuroanatomy 1 85.76 High High
Depression 1 77.80 Quite High
Bordatella Infection 2 46.96 Quite Low
Nociception 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The binding characteristics and distribution profile of [125I][D-Ala2]deltorphin-I were assessed in mouse brain using homogenate binding techniques and quantitative autoradiography. [125I][D-Ala2]deltorphin-I bound with high affinity to a single class of sites (KD = 0.5 nM) in brain membrane preparations and striatal sections.
D-Ala2 Binding (bound) of in brain
1) Confidence 0.18 Published 1991 Journal Peptides Section Abstract Doc Link 1664947 Disease Relevance 0 Pain Relevance 0.20
The data indicate that [125I][D-Ala2]deltorphin-I binds to delta opioid receptors with high affinity and selectivity.
D-Ala2 Binding (binds) of associated with delta opioid receptors
2) Confidence 0.18 Published 1991 Journal Peptides Section Abstract Doc Link 1664947 Disease Relevance 0 Pain Relevance 0.20
On the other hand, chronic administration of naltriben resulted in slight but reproducible elevation in the Bmax value of [3H][D-Pen2, D-Pen5]enkephalin to bind to whole brain membranes in comparison to vehicle-injected controls.
D-Pen2 Binding (bind) of in brain associated with enkephalin
3) Confidence 0.13 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8891592 Disease Relevance 0 Pain Relevance 0.97
The binding of [3H][D-Pen2, D-Pen5]enkephalin to whole brain membranes of chronic 7-benzylidene-7-dehydronaltrexone-treated mice did not differ from chronic vehicle-treated mice.
D-Pen2 Binding (binding) of in brain associated with enkephalin
4) Confidence 0.10 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8891592 Disease Relevance 0 Pain Relevance 1.06
These beta-funaltrexamine-insensitive sites appear to interact only with opioid peptides ([D-Ala2, D-Leu5]enkephalin, [D-Ala2, Met5]enkephalinamide, Tyr-D-Ser-Gly-Phe-Leu-Thr and [D-Ala2, MePhe4, Gly-ol5]enkephalin) but not with nonpeptide agonists.
D-Ala2 Neg (not) Binding (interact) of associated with agonist, enkephalin and opioid
5) Confidence 0.06 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2997432 Disease Relevance 0 Pain Relevance 0.73
Binding and metabolism studies with [3H](D-Ala2,Leu5)enkephalinamide and [3H](D-Ala2,Pro5)enkephalinamide: evidence for a selective interaction of (D-Ala2,Pro5)enkephalinamide with mu-receptors.
D-Ala2 Binding (Binding) of associated with enkephalin
6) Confidence 0.06 Published 1981 Journal Eur. J. Pharmacol. Section Title Doc Link 6271558 Disease Relevance 0 Pain Relevance 0.31
Binding and metabolism studies with [3H](D-Ala2,Leu5)enkephalinamide and [3H](D-Ala2,Pro5)enkephalinamide: evidence for a selective interaction of (D-Ala2,Pro5)enkephalinamide with mu-receptors.
D-Ala2 Binding (interaction) of associated with enkephalin
7) Confidence 0.06 Published 1981 Journal Eur. J. Pharmacol. Section Title Doc Link 6271558 Disease Relevance 0 Pain Relevance 0.32
These results are discussed and interpreted in terms of a selective interaction for (D-Ala2,Pro5)enkephalinamide with mu-receptors and a similar affinity of (D-Ala2,Leu5)enkephalinamide for mu- and delta-receptors.
D-Ala2 Binding (interaction) of
8) Confidence 0.06 Published 1981 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6271558 Disease Relevance 0 Pain Relevance 0.26
Comparison of the filtration and centrifugation methods for assaying [3H](D-ala2, D-leu5)enkephalin binding to mouse brain membranes.
D-ala2 Binding (binding) of in brain associated with enkephalin
9) Confidence 0.05 Published 1983 Journal Neurochem. Res. Section Title Doc Link 6369164 Disease Relevance 0 Pain Relevance 0.27
The binding of [3H](D-ala2, D-leu5)enkephalin (DADLE) to mouse brain membranes was studied via rapid filtration with GF/C filters and via the centrifugation method.
D-ala2 Binding (binding) of in brain associated with enkephalin
10) Confidence 0.05 Published 1983 Journal Neurochem. Res. Section Abstract Doc Link 6369164 Disease Relevance 0 Pain Relevance 0.17
Conversely, the analgesia evoked by opioids binding mu opioid receptors, [D-Ala2, N-MePhe4,Gly-ol5]enkephalin and morphine, appeared consistently and significantly attenuated in mice injected with the ODN to Gx/z alpha.
D-Ala2 Spec (appeared) Binding (binding) of associated with mu opioid receptor, enkephalin, opioid, morphine and analgesia
11) Confidence 0.04 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8531133 Disease Relevance 0 Pain Relevance 1.44
The goal of this study was to determine the relative contribution of entropy and enthalpy to the free energies of binding to recombinant mouse delta-opioid receptors for the peptide agonist, DPDPE ([D-Pen2,D-Pen5]enkephalin), the peptide antagonist, TIPP(psi) (Tyr-Tic(psi)[CH2NH]Phe-Phe-OH), the nonpeptide agonist, SNC80 ((+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl )-3-methoxybenzyl]-N,N-diethylbenzamide), and the nonpeptide antagonist, naltrindole.
D-Pen2 Binding (binding) of associated with tics, antagonist, agonist, enkephalin and delta opioid receptors
12) Confidence 0.04 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9016945 Disease Relevance 0.10 Pain Relevance 0.41
Twice daily injections of [D-Ala2,Glu4] deltorphin II (20 microg/mouse) for 2 days caused an increase in the Kd value, but not the Bmax value of [3H][D-Pen2,D-Pen5]enkephalin to bind to brain membranes.
D-Pen2 Binding (bind) of in brain associated with enkephalin
13) Confidence 0.04 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9369369 Disease Relevance 0 Pain Relevance 1.00
Concurrent treatment of [D-Ala2,Glu4]deltorphin II with LY 235959 reversed the increase in Kd value of [3H][D-Pen2,D-Pen5]enkephalin binding induced by multiple injections of [D-Ala2,Glu4]deltorphin II, but MK-801 had no effect.
D-Pen2 Binding (binding) of associated with enkephalin
14) Confidence 0.04 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9369369 Disease Relevance 0 Pain Relevance 1.10
The results suggest that multiple injections of delta1- and delta2-opioid receptor agonists down-regulate delta1-opioid receptors of the brain by modifying Bmax and Kd values of [3H][D-Pen2,D-Pen5]enkephalin binding, respectively.
D-Pen2 Binding (binding) of in brain associated with agonist, enkephalin and opioid receptor
15) Confidence 0.04 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9369369 Disease Relevance 0 Pain Relevance 1.12
It is concluded that under the conditions of these experiments normorphine and ethylketocyclazocine acted at mu-, U-50488 at kappa-, and dynorphin A1-13 and [D-Ala2,D-Leu5]-enkephalin at delta-receptors.
D-Ala2 Binding (acted) of associated with dynorphin and enkephalin
16) Confidence 0.03 Published 1986 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2869418 Disease Relevance 0.08 Pain Relevance 0.91
The interaction of [D-Pen2,D-Pen5]enkephalin (DPDPE) and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes was investigated.
D-Pen2 Binding (interaction) of associated with opioid receptor and enkephalin
17) Confidence 0.03 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8157053 Disease Relevance 0 Pain Relevance 0.59
Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo.
D-Pen2 Binding (Interaction) of associated with analgesic, opioid receptor and enkephalin
18) Confidence 0.03 Published 1994 Journal Eur. J. Pharmacol. Section Title Doc Link 8157053 Disease Relevance 0 Pain Relevance 1.26
Twice daily injections of (+)-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]-cyclohepten-5,10-imine (MK-801) (0.1 mg/kg, i.p.) or [(-)3-SR,4a-RS,8a-SR-6-(phosphonomethyl)-1,2,3,4,4a,5,6,7,8,8a-decahy droisoquinoline-3-carboxylic acid] (LY 235959) (2 mg/kg, i.p.), the noncompetitive and competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, respectively, for 2 days did not alter the Bmax or Kd value of [3H][D-Pen2,D-Pen5]enkephalin binding to the mouse brain.
D-Pen2 Binding (binding) of in brain associated with antagonist and enkephalin
19) Confidence 0.03 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9369369 Disease Relevance 0 Pain Relevance 0.73
Chronic administration of L-arginine or D-arginine did not alter the Bmax or Kd values of [3H][D-Ala2,MePhe4,Gly5-ol]enkephalin binding to the mouse brain membranes.
D-Ala2 Binding (binding) of in brain associated with enkephalin
20) Confidence 0.03 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9152376 Disease Relevance 0 Pain Relevance 1.66

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox