INT132903

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Context Info
Confidence 0.72
First Reported 2004
Last Reported 2011
Negated 4
Speculated 3
Reported most in Body
Documents 65
Total Number 68
Disease Relevance 33.95
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cd34) cell adhesion (Cd34) cytoplasm (Cd34)
Anatomy Link Frequency
ECs 4
stem cells 4
blood 3
bladder 3
stroma 2
Cd34 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 69 99.56 Very High Very High Very High
Pain 31 95.24 Very High Very High Very High
Arthritis 21 95.04 Very High Very High Very High
COX-2 inhibitor 3 88.48 High High
ketamine 13 88.08 High High
cINOD 4 86.68 High High
Inflammation 319 86.20 High High
Osteoarthritis 35 84.80 Quite High
imagery 91 81.68 Quite High
chemokine 51 81.64 Quite High
Disease Link Frequency Relevance Heat
Cancer 1267 100.00 Very High Very High Very High
Injury 733 99.98 Very High Very High Very High
Obesity 459 99.84 Very High Very High Very High
Apoptosis 388 99.64 Very High Very High Very High
Hepatotoxicity 30 99.58 Very High Very High Very High
Rheumatoid Arthritis 75 99.56 Very High Very High Very High
Severe Combined Immunodeficiency 83 99.04 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 17 99.00 Very High Very High Very High
Bladder Cancer 548 98.86 Very High Very High Very High
Necrosis 57 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ex vivo expanded HSPCs were analyzed for the expression of CD34 and the apoptosis related proteins like caspase 3 and bcl-2.
Gene_expression (expression) of CD34 associated with apoptosis
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.19 Pain Relevance 0
Cells were analyzed for the expression of surface markers like Annexin V, CD34, CD38, Bcl-2, CD33, CD19 and CD3 (BD pharmingen- San Jose, California).
Spec (analyzed) Gene_expression (expression) of CD34
2) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.18 Pain Relevance 0.03
CD34 expression assessed by confocal microscopy revealed that both surface and cytoplasmic pattern (data not shown) of CD34 existed.
Gene_expression (expression) of CD34
3) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.61 Pain Relevance 0.03
There is a well-documented correlation between PB CD34+ count and CD34+ cell yield, although not always observed in healthy PBSC donors (Moncada et al., 2003).
Gene_expression (count) of CD34
4) Confidence 0.67 Published 2010 Journal Transfusion Medicine (Oxford, England) Section Body Doc Link PMC2871169 Disease Relevance 0.30 Pain Relevance 0
CD34+ cell counts
Gene_expression (counts) of CD34
5) Confidence 0.67 Published 2010 Journal Transfusion Medicine (Oxford, England) Section Body Doc Link PMC2871169 Disease Relevance 0.18 Pain Relevance 0.13
Mouse antihuman CD34 antibody (BD pharmingen, San Jose, California), mouse antihuman bcl-2 and rabbit anti human caspase-3 (Santacruz biotech, Santacruz, CA, USA) antibodies were used at 1?
Gene_expression (antibody) of CD34 in Mouse
6) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.18 Pain Relevance 0
Circulating mononuclear cells were isolated and measured for endothelial progenitor cell (defined as CD34+/CD133+ cell) counts.
Gene_expression (cell) of CD34 in mononuclear cells
7) Confidence 0.59 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18633053 Disease Relevance 0.08 Pain Relevance 0
One example is the production by HNSCC and some other cancers of chemoattractive factors (e.g., VEGF) to attract immunosuppressive CD34(+) progenitor cells that inhibit the capacity of intratumoral lymphoid cells to become activated [23, 30].
Gene_expression (production) of CD34 associated with cancer
8) Confidence 0.58 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2723756 Disease Relevance 0.72 Pain Relevance 0
Previous studies have shown delayed engraftment at CD34+ doses less than 8 × 106 kg?
Gene_expression (doses) of CD34
9) Confidence 0.58 Published 2010 Journal Transfusion Medicine (Oxford, England) Section Body Doc Link PMC2871169 Disease Relevance 0.36 Pain Relevance 0.04
Tumors of our cases also showed variable histology, but immunohistochemically, our cases were compatible with GISTs or GANTs based on expression of vimentin (100%), CD117 (100%), and CD34 (66.7%).
Gene_expression (expression) of CD34 associated with cancer
10) Confidence 0.57 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2822305 Disease Relevance 0.91 Pain Relevance 0
Apart from increasing the CD34 gene expression, the presence of zVADfmk and zLLYfmk up regulated the notch receptor 1(3–5 fold), and its ligand jagged 1 (4–5 fold) which is one of the crucial signaling pathway involved in the maintenance of stem cell compartment in the hematopoietic system.
Gene_expression (expression) of CD34 in notch
11) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.17 Pain Relevance 0
The human engraftment in the bone marrow was detected by using huCD45 (pan hematopoietic) and huCD34 (stem/progenitor cells).
Gene_expression (using) of huCD34 in bone marrow
12) Confidence 0.54 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923186 Disease Relevance 0.07 Pain Relevance 0.21
The isolated bone marrow cells express CD34 (9.67%), CD44 (53.90%), Sca-1 (27.25%) and CD45 (60.04%), therefore confirming a phenotype of mesenchymal stem cells.
Gene_expression (express) of CD34 in bone marrow
13) Confidence 0.54 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2974740 Disease Relevance 0.46 Pain Relevance 0.04
Additionally, because multipotent MSCs can express Cd34 and can also be recruited from the bone marrow, as well as surrounding adipose tissue, and contribute to angiogenesis we could not rule out that some of these cells were MSCs as opposed to “classic” EPCs [30].
Gene_expression (express) of Cd34 in adipose tissue associated with obesity
14) Confidence 0.53 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.98 Pain Relevance 0
Effect of TGZ on the expression of VEGF and CD34 within tumors
Gene_expression (expression) of CD34 associated with cancer
15) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 1.23 Pain Relevance 0
For the detection of CD34, sections were treated for 15 min with proteinase K (20 ?
Gene_expression (detection) of CD34
16) Confidence 0.53 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2838820 Disease Relevance 0.42 Pain Relevance 0.06
CD34 (a hematogenic stem cell marker) is also expressed along the surface membrane of the ECs.
Gene_expression (expressed) of CD34 in ECs
17) Confidence 0.52 Published 2005 Journal J Nippon Med Sch Section Abstract Doc Link 16415510 Disease Relevance 0 Pain Relevance 0.07
The results showed both sulindac and celecoxib decreased the micro-vessel density (MVD), which was labeled by either CD34 or VWF staining, within xenografts.
Gene_expression (staining) of CD34
18) Confidence 0.52 Published 2005 Journal Biomed. Pharmacother. Section Abstract Doc Link 16507395 Disease Relevance 0.59 Pain Relevance 0.24
These results indicate that G-CSF-mobilized CD34+ HSCs might be capable of differentiating into ALB-producing cells in the liver of irradiated recipients.
Gene_expression (capable) of CD34 in liver
19) Confidence 0.52 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0 Pain Relevance 0
Radiation-induced liver damage and G-CSF-mobilized CD34+ HSCs administration
Gene_expression (administration) of CD34 in liver associated with hepatotoxicity
20) Confidence 0.52 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0.43 Pain Relevance 0.04

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