INT132938

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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 10.55
Pain Relevance 8.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

kinase activity (Insrr)
Anatomy Link Frequency
endothelial cell 1
spinal cord 1
articular cartilage 1
DRG 1
dorsal horn 1
Insrr (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 10 99.84 Very High Very High Very High
dorsal root ganglion 7 99.68 Very High Very High Very High
Dorsal horn 42 99.16 Very High Very High Very High
opioid receptor 67 98.98 Very High Very High Very High
Nerve growth factor 10 98.92 Very High Very High Very High
Immobilon 8 98.44 Very High Very High Very High
agonist 551 98.40 Very High Very High Very High
Pain 171 98.18 Very High Very High Very High
Spinal cord 106 97.82 Very High Very High Very High
Osteoarthritis 91 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 35 99.68 Very High Very High Very High
Targeted Disruption 423 99.56 Very High Very High Very High
Pain 180 98.18 Very High Very High Very High
Osteoarthritis 96 97.72 Very High Very High Very High
Hyperalgesia 65 97.28 Very High Very High Very High
Neuropathic Pain 107 96.84 Very High Very High Very High
Myelodysplastic Syndromes 60 96.84 Very High Very High Very High
Aging 14 96.44 Very High Very High Very High
Gastrointestinal Stromal Tumor 1 96.08 Very High Very High Very High
Myelofibrosis 28 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrated that repeated s.c. treatment with etorphine, but not morphine, produced a significant increase in protein levels of G protein-coupled receptor kinase 2, dynamin II, beta-arrestin 2 and phosphorylated-conventional protein kinase C in membranes of the mouse spinal cord, suggesting that the etorphine-induced mu-opioid receptor desensitization may result from G protein-coupled receptor kinase 2/dynaminII/beta-arrestin2-dependent phosphorylation of mu-opioid receptors.
Phosphorylation (phosphorylation) of receptor in spinal cord associated with kinase c, mu opioid receptor, opioid receptor, spinal cord, morphine and immobilon
1) Confidence 0.03 Published 2006 Journal Neuroscience Section Abstract Doc Link 16417975 Disease Relevance 0 Pain Relevance 1.25
Immunoblotting analyses of the autophosphorylation of the ErbB receptor were performed using the prefrontal cortex region.
Phosphorylation (autophosphorylation) of receptor in cortex
2) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.19 Pain Relevance 0
Autophosphorylation of ErbB receptor in HB-EGF KO mice
Phosphorylation (Autophosphorylation) of receptor associated with targeted disruption
3) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759290 Disease Relevance 0.19 Pain Relevance 0
The upregulation of NGF coincided with enhanced tropomyosin-related kinase A receptor phosphorylation in the DRG.
Phosphorylation (phosphorylation) of receptor in DRG associated with dorsal root ganglion and nerve growth factor
4) Confidence 0.02 Published 2009 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 19816194 Disease Relevance 1.32 Pain Relevance 1.33
DOR-eGFP receptor internalization in vivo parallels receptor phosphorylation and uncoupling from G proteins
Phosphorylation (phosphorylation) of receptor
5) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.37 Pain Relevance 0.45
Finally, we show that receptor phosphorylation and uncoupling parallels receptor internalization, and that restoration of surface receptors reinstate opioid analgesia.
Phosphorylation (phosphorylation) of receptor associated with opioid and analgesia
6) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.46 Pain Relevance 0.87
SNC80 produced robust DOR-eGFP endocytosis, which was concomitant with an increase in receptor phosphorylation and a decrease in [35S]GTP?
Phosphorylation (phosphorylation) of receptor
7) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.07 Pain Relevance 0.23
In contrast, SNC80 may interact differentially with the receptor binding pocket to promote a distinct active conformation, which in turn triggers signaling, as well as receptor phosphorylation and internalization.
Phosphorylation (phosphorylation) of receptor
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.09 Pain Relevance 0.23
The results of this study indicate that DOR-eGFP internalization was strongly correlated to receptor phosphorylation and uncoupling from G proteins.
Phosphorylation (phosphorylation) of receptor
9) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.06 Pain Relevance 0.25
Finally, we show that receptor phosphorylation and uncoupling parallels receptor internalization, and that restoration of surface receptors reinstate opioid analgesia.
Phosphorylation (phosphorylation) of receptor associated with opioid and analgesia
10) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.41 Pain Relevance 0.82
The agonist-activated receptor is initially phosphorylated by GPCR kinases (GRKs), and the phosphorylated receptor, in turn, recruits ?
Phosphorylation (phosphorylated) of receptor associated with agonist
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.07 Pain Relevance 0.08
DOR-eGFP receptor internalization in vivo parallels receptor phosphorylation and uncoupling from G proteins
Phosphorylation (phosphorylation) of receptor
12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.36 Pain Relevance 0.44
However, ARM390 may bind in a mode that produces receptor signaling, but may not cause subsequent receptor phosphorylation and internalization.
Phosphorylation (phosphorylation) of receptor
13) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.10 Pain Relevance 0.22
Formalin-induced pain behavior was attenuated in the second phase, and this correlated with diminished tyrosine phosphorylation of N-methyl-D-aspartic acid (NMDA) receptor subunit NR2B in the dorsal horn.
Phosphorylation (phosphorylation) of receptor in dorsal horn associated with pain and dorsal horn
14) Confidence 0.01 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2992507 Disease Relevance 1.74 Pain Relevance 1.49
NR2B receptor phosphorylation was also detected after CFA injection in the hindpaw (Additional file 1, S4B).
Phosphorylation (phosphorylation) of receptor
15) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2992507 Disease Relevance 0.64 Pain Relevance 0.39
These mechanisms include: blocking the binding of VEGF121 and VEGF165 to the KDR/Flk-1 receptor, which mediates endothelial cell motility and proliferation; blocking phosphorylation of the tyrosine receptor; and blocking activation of the intracellular signaling kinases ERK, p38 MAPK, and p125 FAK [34,35].
Phosphorylation (phosphorylation) of receptor in endothelial cell
16) Confidence 0.01 Published 2010 Journal BMC Med Section Body Doc Link PMC2989928 Disease Relevance 1.14 Pain Relevance 0.04
One of these mutations, D842V, resulted in receptors displaying ligand-independent receptor phosphorylation and activation of downstream signaling molecules [14].
Phosphorylation (phosphorylation) of receptor
17) Confidence 0.01 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2234427 Disease Relevance 0.69 Pain Relevance 0.03
A sustained activation of these signaling kinases has been linked to abrogation of the activation of the PI3K-PKB/Akt pathway by insulin by inducing inhibitory serine phosphorylations on the insulin receptor and IRS1/2 [23].
Phosphorylation (phosphorylations) of receptor
18) Confidence 0.01 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.64 Pain Relevance 0.09
CKI has been shown to physically associate with GABAA receptors in a rhythmic manner in the SCN [58], and CKII has been shown to phosphorylate GABAC receptor subunits [59].
Phosphorylation (phosphorylate) of receptor
19) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0 Pain Relevance 0.31
The type I receptor then induces the phosphorylation of receptor-regulated SMADs (R-SMADs) that bind the coSMAD.
Phosphorylation (phosphorylation) of receptor
20) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.42 Pain Relevance 0.13

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