INT132943

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Context Info
Confidence 0.00
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Rbm39) RNA binding (Rbm39) nucleus (Rbm39)
kinase activity (Insrr)
Anatomy Link Frequency
spinal cord 1
Insrr (Mus musculus)
Rbm39 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 1 100.00 Very High Very High Very High
Immobilon 8 99.28 Very High Very High Very High
opioid receptor 4 98.98 Very High Very High Very High
Morphine 8 98.40 Very High Very High Very High
Spinal cord 3 97.82 Very High Very High Very High
Kinase C 1 97.06 Very High Very High Very High
Opioid 1 80.04 Quite High
tolerance 6 79.60 Quite High
agonist 1 75.00 Quite High
antinociception 2 62.16 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrated that repeated s.c. treatment with etorphine, but not morphine, produced a significant increase in protein levels of G protein-coupled receptor kinase 2, dynamin II, beta-arrestin 2 and phosphorylated-conventional protein kinase C in membranes of the mouse spinal cord, suggesting that the etorphine-induced mu-opioid receptor desensitization may result from G protein-coupled receptor kinase 2/dynaminII/beta-arrestin2-dependent phosphorylation of mu-opioid receptors.
receptor Positive_regulation (phosphorylation) of receptors in spinal cord associated with kinase c, mu opioid receptor, opioid receptor, spinal cord, morphine and immobilon
1) Confidence 0.00 Published 2006 Journal Neuroscience Section Abstract Doc Link 16417975 Disease Relevance 0 Pain Relevance 1.27

General Comments

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