INT13295

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Context Info
Confidence 0.68
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 13.02
Pain Relevance 5.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Cdkn2a) aging (Cdkn2a) DNA binding (Cdkn2a)
protein complex (Cdkn2a) cytoplasm (Cdkn2a) nucleolus (Cdkn2a)
Anatomy Link Frequency
striatum 1
skin 1
pigmentation 1
cortex 1
nevus 1
Cdkn2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 12 99.84 Very High Very High Very High
opioid receptor 5 99.80 Very High Very High Very High
Kinase C 3 99.60 Very High Very High Very High
anesthesia 11 99.16 Very High Very High Very High
Clonidine 20 98.96 Very High Very High Very High
dopamine receptor 19 98.86 Very High Very High Very High
Paracetamol 1 96.92 Very High Very High Very High
ketamine 18 96.88 Very High Very High Very High
melanocortin 1 receptor 12 95.20 Very High Very High Very High
imagery 33 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Acute Renal Failure 225 100.00 Very High Very High Very High
Lung Injury 35 100.00 Very High Very High Very High
Cv Unclassified Under Development 12 99.84 Very High Very High Very High
Body Weight 16 99.60 Very High Very High Very High
Nevus 9 99.46 Very High Very High Very High
Skin Cancer 18 98.48 Very High Very High Very High
Injury 42 97.48 Very High Very High Very High
Necrosis 16 97.16 Very High Very High Very High
Sunburn 6 96.80 Very High Very High Very High
Renal Disease 42 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine the effect of clonidine, administered orally, on the prolonged course of HgCl2-induced ARF, two groups of rats were studied for a period of 5 days after injury.
Positive_regulation (induced) of ARF associated with injury and clonidine
1) Confidence 0.68 Published 1983 Journal J. Lab. Clin. Med. Section Abstract Doc Link 6226755 Disease Relevance 0.32 Pain Relevance 0.41
The inhibition of cell proliferation by FK228 treatment was accompanied by the induction of p16INK4a and the up-regulation of p21WAF1/Cip1 expression in RASFs.
Positive_regulation (induction) of p16INK4a
2) Confidence 0.49 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.14 Pain Relevance 0.40
These results suggest that glycerol-induced ARF results in several changes in the pharmacokinetics of cyclosporin in rats.
Positive_regulation (induced) of ARF associated with acute renal failure
3) Confidence 0.47 Published 1999 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10385211 Disease Relevance 0.75 Pain Relevance 0.14
These results indicate that oral clonidine, administered either before or shortly after HgCl2-induced ARF, exerts a salutory effect on the course and mortality of ARF by providing protection of renal function and enhancement of the recovery process.
Positive_regulation (induced) of ARF associated with clonidine
4) Confidence 0.46 Published 1983 Journal J. Lab. Clin. Med. Section Abstract Doc Link 6226755 Disease Relevance 0.28 Pain Relevance 0.69
RHC variants, considered either alone or in the presence of pigmentation and nevus phenotypes, were found to increase significantly CDKN2A penetrance.
Positive_regulation (increase) of CDKN2A in nevus associated with nevus
5) Confidence 0.44 Published 2005 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 16214921 Disease Relevance 1.02 Pain Relevance 0.29
Penetrance of CDKN2A gene was found to be significantly influenced by host factors (nevus phenotypes and sunburn) on one hand and by variants of MC1R gene (RHC variants consistently associated with red hair and fair skin) on the other hand.
Positive_regulation (Penetrance) of CDKN2A gene in skin associated with melanocortin 1 receptor, sunburn and nevus
6) Confidence 0.44 Published 2005 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 16214921 Disease Relevance 0.77 Pain Relevance 0.32
ARF was defined as a two-fold increase in creatinine level from pre-ARF to 48 hr after ARF.
Positive_regulation (increase) of ARF associated with acute renal failure
7) Confidence 0.43 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779283 Disease Relevance 1.07 Pain Relevance 0.16
ARF was defined as a two-fold increase in creatinine level from pre-ARF to 48 hr after ARF.
Positive_regulation (increase) of ARF associated with acute renal failure
8) Confidence 0.37 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779283 Disease Relevance 1.19 Pain Relevance 0.16
Acute renal failure (ARF) caused by ischemia or nephrotoxins involves both vascular and tubular events, and vascular ischemia is considered a major contributor to radiocontrast-induced nephropathy (RCIN) (1).
Positive_regulation (caused) of ARF associated with acute renal failure, ischemia and renal disease
9) Confidence 0.37 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779283 Disease Relevance 1.18 Pain Relevance 0.24
ARF was defined as a two-fold increase in creatinine level from pre-ARF to 48 hr after ARF.
Positive_regulation (increase) of ARF associated with acute renal failure
10) Confidence 0.37 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779283 Disease Relevance 1.18 Pain Relevance 0.16
The administration of epidermal growth factor after induction of ischemic ARF in rats has been shown to enhance tubular regeneration and accelerate recovery of kidney function.
Positive_regulation (induction) of ARF in kidney
11) Confidence 0.37 Published 1998 Journal J. Cardiothorac. Vasc. Anesth. Section Abstract Doc Link 9801983 Disease Relevance 0.59 Pain Relevance 0.19
Additionally, p16(INK4a) promoter methylation was analyzed by a methylation specific polymerase test.
Spec (analyzed) Positive_regulation (methylation) of p16
12) Confidence 0.36 Published 2001 Journal Surgery Section Body Doc Link 11283541 Disease Relevance 0.15 Pain Relevance 0
Two of the 10 specimens with PanIN revealed an inactivating hypermethylation of the p16(INK4a) promoter.
Positive_regulation (hypermethylation) of p16
13) Confidence 0.36 Published 2001 Journal Surgery Section Body Doc Link 11283541 Disease Relevance 0.12 Pain Relevance 0
Glycerol induced severe ARF under pentobarbital anesthesia (Cr, 2.8 +/- 0.3 mg/dl; severe tubular necrosis).
Positive_regulation (induced) of ARF associated with necrosis and anesthesia
14) Confidence 0.35 Published 1998 Journal J. Am. Soc. Nephrol. Section Abstract Doc Link 9527408 Disease Relevance 1.00 Pain Relevance 0.44
The results showed that both D2R mRNAs were detected in rat striatum at birth, gradually increased until day 16 postnatally (P16), then declined slightly.
Positive_regulation (increased) of P16 in striatum associated with dopamine receptor
15) Confidence 0.25 Published 1991 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1665109 Disease Relevance 0 Pain Relevance 0.55
RHC variants, considered either alone or in the presence of pigmentation and nevus phenotypes, were found to increase significantly CDKN2A penetrance.
Positive_regulation (increase) of CDKN2A in pigmentation associated with nevus
16) Confidence 0.15 Published 2005 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 16214921 Disease Relevance 1.02 Pain Relevance 0.29
Indeed, the PARP pathway is activated both in VILI and ARF [5,15-18].
Positive_regulation (activated) of ARF associated with lung injury and acute renal failure
17) Confidence 0.14 Published 2010 Journal Crit Care Section Body Doc Link PMC2887157 Disease Relevance 1.26 Pain Relevance 0.07
The DAMGO-mediated PLD2 activation was inhibited by brefeldin A, an inhibitor of ADP-ribosylation factor (ARF) but not by the protein kinase C (PKC) inhibitor calphostin C indicating that opioid receptor-mediated activation of PLD2 is ARF- but not PKC-dependent.
Positive_regulation (activation) of ARF associated with kinase c and opioid receptor
18) Confidence 0.06 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12519790 Disease Relevance 0 Pain Relevance 0.78
cortex, D1 receptor activation typically inhibits IRKC by direct effects of cAMP on IRK channels, but strong
Positive_regulation (activation) of inhibits in cortex
19) Confidence 0.01 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2519792 Disease Relevance 0 Pain Relevance 0.17

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