INT132951

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Context Info
Confidence 0.57
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.79
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (GJA1) Golgi apparatus (GJA1) endoplasmic reticulum (GJA1)
cell-cell signaling (GJA1) cytoplasm (GJA1) signal transducer activity (GJA1)
Anatomy Link Frequency
glial cell 1
GJA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 2 95.96 Very High Very High Very High
imagery 3 90.68 High High
Central nervous system 1 87.36 High High
Dismenorea 10 58.72 Quite High
antagonist 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
iatrogenic 2 5.00 Very Low Very Low Very Low
potassium channel 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cleidocranial Dysplasia 6 99.56 Very High Very High Very High
Glioma 2 97.28 Very High Very High Very High
Congenital Anomalies 2 81.12 Quite High
Dysmenorrhea 10 58.72 Quite High
Targeted Disruption 2 5.88 Low Low
Premature Birth 6 5.00 Very Low Very Low Very Low
Anencephaly 4 5.00 Very Low Very Low Very Low
Hypertension 2 5.00 Very Low Very Low Very Low
Cv General 3 Under Development 2 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Detailed studies of GJA1 gene regulation indicate that the family of activator protein-1 transcription factors is critical to determine the level of GJA1 expression in myometrial cells [35,36].
Regulation (regulation) of GJA1
1) Confidence 0.57 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0 Pain Relevance 0
To understand how ODDD-associated mutations affect Cx43 signaling in cells of glial origin, we conducted studies in rat C6 glioma cells, a communication-deficient glial cell line that expresses low levels of Cx43.
Regulation (affect) of Cx43 in glial cell associated with cleidocranial dysplasia and glioma
2) Confidence 0.44 Published 2006 Journal J. Cell. Sci. Section Abstract Doc Link 16418219 Disease Relevance 0.73 Pain Relevance 0.18
A number of protein kinases are involved in the functional regulation of GJA1, including PRKA, PRKC and mitogen-activated protein kinase 1 (MAPK1).
Regulation (regulation) of GJA1
3) Confidence 0.25 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892059 Disease Relevance 0.06 Pain Relevance 0.06

General Comments

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