INT13296

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Context Info
Confidence 0.66
First Reported 1987
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 2.70
Pain Relevance 9.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Drd2) plasma membrane (Drd2) signal transducer activity (Drd2)
Anatomy Link Frequency
brain 3
corpus striatum 3
neurons 2
caudate-putamen 2
nucleus 1
Drd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 146 100.00 Very High Very High Very High
dopamine receptor 50 100.00 Very High Very High Very High
Enkephalin 26 100.00 Very High Very High Very High
substance P 22 100.00 Very High Very High Very High
Neuropeptide 9 100.00 Very High Very High Very High
Dynorphin 3 100.00 Very High Very High Very High
opiate 5 99.80 Very High Very High Very High
adenocard 1 99.80 Very High Very High Very High
withdrawal 12 99.32 Very High Very High Very High
Morphine 7 98.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 304 99.64 Very High Very High Very High
Schizophrenia 4 98.88 Very High Very High Very High
Stress 14 98.24 Very High Very High Very High
Opiate Addiction 2 96.32 Very High Very High Very High
Targeted Disruption 4 93.52 High High
Depression 8 93.16 High High
Tourette's Syndrome 17 86.92 High High
Disease 8 85.76 High High
Dystonia 1 84.80 Quite High
Cognitive Disorder 3 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to investigate whether early VH lesion in rats alters the expression of genes implicated in schizophrenia pre- and post-puberty, we studied the mRNA expression of neuropeptides (substance P, dynorphin and enkephalin), dopamine D1, dopamine D2, and NMDA (subunits NR1 and NR2A) receptors in this animal model.
Transcription (expression) of dopamine D2 associated with dopamine, dynorphin, neuropeptide, enkephalin, hippocampus, schizophrenia and substance p
1) Confidence 0.66 Published 2009 Journal Schizophr. Res. Section Abstract Doc Link 19500946 Disease Relevance 0.27 Pain Relevance 0.64
Substance P(1-7) affects the expression of dopamine D2 receptor mRNA in male rat brain during morphine withdrawal.
Transcription (expression) of dopamine D2 receptor in brain associated with dopamine, withdrawal, morphine and substance p
2) Confidence 0.52 Published 2003 Journal Peptides Section Title Doc Link 12576096 Disease Relevance 0.14 Pain Relevance 1.20
In this study we have investigated the effect of the heptapeptide fragment on the expression of the brain dopamine D2 receptor mRNA and on the withdrawal reaction, as well, in morphine-dependent rats.
Transcription (expression) of dopamine D2 receptor in brain associated with dopamine, withdrawal and morphine
3) Confidence 0.52 Published 2003 Journal Peptides Section Abstract Doc Link 12576096 Disease Relevance 0.10 Pain Relevance 1.11
The ontogenetic expression of the D2 dopamine receptor (D2R) mRNA has been characterized in rat corpus striatum by in situ hybridization histochemistry and Northern and slot blot analyses using oligonucleotide probes directed toward either the D2R-A subtype of the D2R mRNA or to both the D2R-A and D2R-B subtypes of the D2R mRNA.
Transcription (expression) of D2 dopamine receptor in corpus striatum associated with dopamine receptor
4) Confidence 0.51 Published 1991 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 1665109 Disease Relevance 0 Pain Relevance 0.40
This is analogous to the contribution of the DRD2 gene to both hyperactivity and poor response to stress in humans.
Transcription (contribution) of DRD2 gene associated with stress and attention deficit hyperactivity disorder
5) Confidence 0.46 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2626918 Disease Relevance 1.22 Pain Relevance 0.16
A smaller but consistent increase in dopamine D2 receptor mRNA levels was also found on adjacent sections of the striatum only in animals injected with 150 micrograms of 6-hydroxydopamine.
Transcription (levels) of dopamine D2 receptor in striatum associated with dopamine
6) Confidence 0.45 Published 1993 Journal Brain Res. Section Abstract Doc Link 7902185 Disease Relevance 0 Pain Relevance 0.40
This study used in-situ hybridization to examine D1 and D2 receptor mRNA expression in the brains of rats subjected to chronic mild stress and/or chronic treatment (5 weeks) with the antidepressant drugs imipramine and fluoxetine.
Spec (examine) Transcription (expression) of D2 receptor in brains associated with stress, antidepressant and fluoxetine
7) Confidence 0.40 Published 1997 Journal Behav Pharmacol Section Abstract Doc Link 9832973 Disease Relevance 0.40 Pain Relevance 0.43
Individual neurons of the central lateral central nucleus express the dopamine-2-receptor subtype mRNA.
Transcription (express) of dopamine-2-receptor in nucleus associated with dopamine
8) Confidence 0.39 Published 1998 Journal Adv Anat Embryol Cell Biol Section Abstract Doc Link 9586282 Disease Relevance 0.05 Pain Relevance 0.66
Ontogenetic expression of D2 dopamine receptor mRNA in rat corpus striatum.
Transcription (expression) of D2 dopamine receptor in corpus striatum associated with dopamine receptor
9) Confidence 0.39 Published 1991 Journal Brain Res. Dev. Brain Res. Section Title Doc Link 1665109 Disease Relevance 0 Pain Relevance 0.54
Quantitative densitometry was used to measure changes in mRNA levels for preproenkephalin A (ENK), D1 dopamine receptor, protachykinin (SubP), glutamic acid decarboxylase (GAD65), and D2 dopamine receptor.
Transcription (levels) of D2 dopamine receptor associated with dopamine receptor
10) Confidence 0.38 Published 1998 Journal Brain Res. Section Abstract Doc Link 9630515 Disease Relevance 0 Pain Relevance 0.34
Codistribution studies suggest that they express the dopamine-2-receptor subtype mRNA. 4.1.2 Basal Complex: The basal complex receives dopaminergic and noradrenergic innervation, the latter mainly originating in the locus coeruleus.
Transcription (express) of dopamine-2-receptor in locus coeruleus associated with dopamine and locus ceruleus
11) Confidence 0.38 Published 1998 Journal Adv Anat Embryol Cell Biol Section Abstract Doc Link 9586282 Disease Relevance 0 Pain Relevance 0.57
We demonstrate that socially isolated but not group housed Flinders sensitive line rats had lower dopamine D2 receptor mRNA levels compared with Sprague-Dawley rats.
Transcription (levels) of D2 receptor associated with dopamine
12) Confidence 0.34 Published 2007 Journal Neuroreport Section Abstract Doc Link 17558292 Disease Relevance 0.09 Pain Relevance 0.56
Macroscopic analysis demonstrated that haloperidol treatment two times 1 mg/kg per day during seven, 14 and 21 days increased D2 receptor mRNA level in the caudate-putamen.
Transcription (level) of D2 receptor in caudate-putamen
13) Confidence 0.29 Published 1991 Journal Neuroscience Section Abstract Doc Link 1754061 Disease Relevance 0 Pain Relevance 0.08
Haloperidol treatment did not modify the number of medium-sized enkephalinergic neurons expressing the D2 receptor mRNA.
Transcription (expressing) of D2 receptor in neurons
14) Confidence 0.29 Published 1991 Journal Neuroscience Section Abstract Doc Link 1754061 Disease Relevance 0 Pain Relevance 0.14
Variations of D2 receptor mRNA level were studied and measured at the macroscopic level of densitometric analysis of X-ray film and at the microscopic level by counting of autoradiographic silver grains in striatal cells.
Transcription (level) of D2 receptor
15) Confidence 0.29 Published 1991 Journal Neuroscience Section Abstract Doc Link 1754061 Disease Relevance 0 Pain Relevance 0.09
However, in the caudate putamen, the mRNA levels, for dopamine D2 and adenosine 2A receptor, dynorphin, and substance P were lower during the day than during the night, whereas the expression of dopamine D1 receptor, enkephalin, and somatostatin was stable.
Transcription (levels) of dopamine D2 in caudate putamen associated with adenocard, dopamine, dynorphin, somatostatin, enkephalin and substance p
16) Confidence 0.29 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15016424 Disease Relevance 0.34 Pain Relevance 0.73
Striatal neurons express increased level of dopamine D2 receptor mRNA in response to haloperidol treatment: a quantitative in situ hybridization study.
Transcription (express) of D2 receptor in neurons associated with dopamine and enkephalin
17) Confidence 0.25 Published 1991 Journal Neuroscience Section Title Doc Link 1754061 Disease Relevance 0 Pain Relevance 0.20
This was also the case for the distribution of dopamine D2 and opiate receptors (as revealed by [3H]spiroperidol and [3H]diprenorphine autoradiography, respectively), whereas muscarinic receptor binding was even throughout the grafts.
Transcription (distribution) of dopamine D2 associated with dopamine and opiate
18) Confidence 0.10 Published 1987 Journal Neuroscience Section Abstract Doc Link 2823174 Disease Relevance 0.07 Pain Relevance 0.82

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