INT132967

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.09
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Hcn2) plasma membrane (Hcn2) transmembrane transport (Hcn2)
Anatomy Link Frequency
oocytes 1
embryonic kidney 1
Hcn2 (Mus musculus)
Pain Link Frequency Relevance Heat
hCN2 8 100.00 Very High Very High Very High
Angina 1 93.88 High High
Neuronal excitability 1 75.00 Quite High
Thalamus 1 70.68 Quite High
gABA 1 61.60 Quite High
HCN1 2 58.08 Quite High
anesthesia 1 55.20 Quite High
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 1 93.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we characterized the effect of the HCN channel blocker, ZD7288 [4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino) pyrimidinium chloride] on HCN2 channels that were heterologously expressed in Xenopus oocytes.
Gene_expression (expressed) of HCN2 in oocytes associated with hcn2
1) Confidence 0.71 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17578902 Disease Relevance 0.09 Pain Relevance 0.29
In human embryonic kidney (HEK)293 cells expressing recombinant mouse HCN2 channels, propofol decreased I(h) and slowed the rate of channel activation.
Gene_expression (expressing) of HCN2 in embryonic kidney associated with hcn2
2) Confidence 0.51 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16420453 Disease Relevance 0 Pain Relevance 0.24

General Comments

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