INT132992

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp3) nucleus (Igfbp3)
Anatomy Link Frequency
hypothalamus 2
Igfbp3 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 2 98.76 Very High Very High Very High
metalloproteinase 2 98.44 Very High Very High Very High
anesthesia 2 83.28 Quite High
ketamine 1 80.64 Quite High
nMDA receptor 1 38.60 Quite Low
Locus ceruleus 8 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 44 98.88 Very High Very High Very High
Cancer 4 92.52 High High
Hyperglycemia 1 88.28 High High
Congenital Anomalies 1 86.52 High High
Sleep Disorders 69 70.80 Quite High
Death 10 70.24 Quite High
Injury 1 39.24 Quite Low
Apoptosis 4 27.92 Quite Low
Sprains And Strains 5 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our goal was to determine, in a murine model, whether matrix metalloproteinase-9 (MMP-9), a known protease of IGFBP-3, is responsible for the postoperative decrease in serum IGFBP-3 levels.
Spec (whether) Negative_regulation (decrease) of Gene_expression (levels) of IGFBP-3 associated with metalloproteinase
1) Confidence 0.37 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.19 Pain Relevance 0.21
Overexpression of hmutIGFBP3, a mutant form that does not bind IGF, also reduces hypocretin peptide content in brainstem but not in hypothalamus suggesting both IGF dependent and independent effects on hypocretin transmission.
Negative_regulation (reduces) of Gene_expression (Overexpression) of hmutIGFBP3 in hypothalamus associated with medulla
2) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.65 Pain Relevance 0.05

General Comments

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