INT132994

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 9.40
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
alveolar macrophages 4
fibroblasts 4
neutrophils 4
pleural fluid 3
cleavage 2
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 245 100.00 Very High Very High Very High
fibrosis 94 99.96 Very High Very High Very High
Central nervous system 20 98.56 Very High Very High Very High
Inflammatory marker 6 97.82 Very High Very High Very High
Inflammation 364 97.60 Very High Very High Very High
Potency 5 96.70 Very High Very High Very High
cytokine 128 93.88 High High
dexamethasone 137 92.32 High High
chemokine 72 90.12 High High
Inflammatory response 57 83.52 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Disease 313 99.98 Very High Very High Very High
Fibrosis 49 99.96 Very High Very High Very High
Stroke 81 99.20 Very High Very High Very High
Nicotine Addiction 99 99.00 Very High Very High Very High
Mycobacterial Infection 135 98.76 Very High Very High Very High
Cancer 139 98.44 Very High Very High Very High
Pulmonary Fibrosis 49 97.68 Very High Very High Very High
INFLAMMATION 430 97.66 Very High Very High Very High
Neutropenia 2 95.36 Very High Very High Very High
Meningitis 8 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggests that rapid MMP-9 release by mononuclear cells leads to an increase in serum levels of this protease postoperatively.
Positive_regulation (increase) of Localization (release) of MMP-9 in mononuclear cells
1) Confidence 0.42 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.05 Pain Relevance 0.13
MMP-9 is quantitatively the most significant MMP released by macrophages and concentrations are increased in lungs and pleural fluid of TB patients [19], [20].
Positive_regulation (increased) of Localization (released) of MMP-9 in pleural fluid associated with mycobacterial infection
2) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 0.99 Pain Relevance 0.41
synergistically increases MMP-9 secretion from astrocytes, the most abundant CNS cell and a key component of the BBB [12].
Positive_regulation (increases) of Localization (secretion) of MMP-9 in astrocytes associated with central nervous system
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 1.31 Pain Relevance 0.46
Indeed, with increasing complexity of the model system, the importance of MMP-2 and MMP-9 became apparent.
Positive_regulation (increasing) of Localization (importance) of MMP-9 associated with metalloproteinase
4) Confidence 0.34 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450297 Disease Relevance 0.92 Pain Relevance 0.59
Recruited neutrophils release MMP-9, which has a protective role in bleomycin-induced fibrosis [17] through cleavage of potential profibrotic mediators such as insulin-like growth factor binding protein-3 (IGFBP3).
Positive_regulation (induced) of Localization (release) of MMP-9 in cleavage associated with fibrosis
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2951918 Disease Relevance 0.70 Pain Relevance 0.27
PDE4 inhibitor cilomilast was also shown to suppress the release and activation of MMP-1 and MMP-9 from lung fibroblasts, which are known to be involved in PF progression [18].
Positive_regulation (activation) of Localization (release) of MMP-9 in fibroblasts associated with fibrosis
6) Confidence 0.20 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2881047 Disease Relevance 0.71 Pain Relevance 0.25
The potency of combined PDE4B/4D and 7A AON on inflammatory markers in vitro is in line with their protective effect in vivo, as evidenced by their ability to reduce the smoke-induced recruitment of neutrophils and secretion of KC and MMP-9 in mice.
Positive_regulation (induced) of Localization (secretion) of MMP-9 in neutrophils associated with inflammatory marker and potency
7) Confidence 0.13 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.39 Pain Relevance 0.16
Indeed, neutrophils contain and degranulate gelatinase granules resulting in release of pro-MMP-9 and MMP-9 within a day after stroke onset [107].
Positive_regulation (resulting) of Localization (release) of MMP-9 in neutrophils associated with stroke
8) Confidence 0.12 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2988764 Disease Relevance 0.59 Pain Relevance 0.17
MMP-9 is quantitatively the most significant MMP released by macrophages and concentrations are increased in lungs and pleural fluid of TB patients [19], [20].
Positive_regulation (increased) of in lungs Localization (released) of MMP-9 in pleural fluid associated with mycobacterial infection
9) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 0.99 Pain Relevance 0.41
Cigarette smoke treatment of alveolar macrophages from subjects with COPD induced increased release of MMP-9 compared to that of non-smokers.
Positive_regulation (induced) of Localization (release) of MMP-9 in alveolar macrophages associated with nicotine addiction, pulmonary disease and metalloproteinase
10) Confidence 0.09 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.88 Pain Relevance 0.35
Cigarette smoke treatment of alveolar macrophages from subjects with COPD induced increased release of MMP-9 compared to that of non-smokers.
Positive_regulation (increased) of Localization (release) of MMP-9 in alveolar macrophages associated with nicotine addiction, pulmonary disease and metalloproteinase
11) Confidence 0.09 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.88 Pain Relevance 0.35
Mast cell-fibroblast interactions induce the release of proteases important for tissue remodeling, such as MMP-9.
Positive_regulation (induce) of Localization (release) of MMP-9 in fibroblast
12) Confidence 0.04 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.99 Pain Relevance 0.21

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox