INT132995

Context Info Confidence 0.44 First Reported 2005 Last Reported 2005 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.36 Pain Relevance 0.38

extracellular space (Igfbp3) nucleus (Igfbp3)

Igfbp3 (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 4 98.44 anesthesia 2 82.72 ketamine 2 80.08

Disease Link Frequency Relevance Heat Targeted Disruption 2 98.32 Cancer 2 93.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We have previously demonstrated a significant decrease in the serum concentration of intact insulin-like growth factor-binding protein (IGFBP-3) after laparotomy.

Negative_regulation (decrease) of IGFBP-3

1) Confidence 0.44 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.17 Pain Relevance 0.17

Our goal was to determine, in a murine model, whether matrix metalloproteinase-9 (MMP-9), a known protease of IGFBP-3, is responsible for the postoperative decrease in serum IGFBP-3 levels.

Spec (whether) Negative_regulation (decrease) of IGFBP-3 associated with metalloproteinase

2) Confidence 0.38 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.19 Pain Relevance 0.21

General Comments

This test has worked.