INT132996

Context Info Confidence 0.49 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 3.20 Pain Relevance 0.50

extracellular space (Igfbp3) nucleus (Igfbp3)

Anatomy Link Frequency hypothalamus 2 fibroblasts 2 Igfbp3 (Mus musculus)

Pain Link Frequency Relevance Heat medulla 2 96.68 anesthesia 3 92.32 metalloproteinase 7 92.12 ketamine 2 89.68 Bioavailability 1 78.96 Inflammation 22 65.84 cytokine 19 60.88 fibrosis 9 53.48 chemokine 15 48.72 nMDA receptor 1 38.60

Disease Link Frequency Relevance Heat Stomach Cancer 116 99.84 Gastritis 14 99.28 Emphysema 1 99.20 Targeted Disruption 45 97.48 Cancer 130 92.64 Hyperglycemia 1 88.28 Congenital Anomalies 1 86.52 Disease 19 84.32 Metastasis 14 83.68 Apoptosis 8 73.36

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

, PDGFR-B and IGFBP-3) found to be overexpressed in gastric cancers relative to PN and AN (with the exception of CFD/Adipsin which was overexpressed in PN relative to gastric cancers and AN) were studied for their protein levels in tumour, corresponding PN and in AN tissues.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of IGFBP-3 associated with cancer and stomach cancer

1) Confidence 0.49 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.55 Pain Relevance 0

These mice over-express human IGFBP-3.

Positive_regulation (over-express) of Gene_expression (express) of IGFBP-3

2) Confidence 0.44 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.19 Pain Relevance 0.22

Increased Igfbp3 expression is associated with emphysema [32] and senescent fibroblasts, where it results in Igf1 sequestration and reduced cell proliferation [33,34].

Positive_regulation (Increased) of Gene_expression (expression) of Igfbp3 in fibroblasts associated with emphysema

3) Confidence 0.39 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.65 Pain Relevance 0.12

Overexpression of hmutIGFBP3, a mutant form that does not bind IGF, also reduces hypocretin peptide content in brainstem but not in hypothalamus suggesting both IGF dependent and independent effects on hypocretin transmission.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of hmutIGFBP3 in hypothalamus associated with medulla

4) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.64 Pain Relevance 0.05

Using IHC, IGFBP3 was found to be overexpressed in gastric cancers relative to the normal gastric tissue [40].

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of IGFBP3 associated with stomach cancer

5) Confidence 0.08 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.17 Pain Relevance 0.10

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