INT132996

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.20
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Igfbp3) nucleus (Igfbp3)
Anatomy Link Frequency
hypothalamus 2
fibroblasts 2
Igfbp3 (Mus musculus)
Pain Link Frequency Relevance Heat
medulla 2 96.68 Very High Very High Very High
anesthesia 3 92.32 High High
metalloproteinase 7 92.12 High High
ketamine 2 89.68 High High
Bioavailability 1 78.96 Quite High
Inflammation 22 65.84 Quite High
cytokine 19 60.88 Quite High
fibrosis 9 53.48 Quite High
chemokine 15 48.72 Quite Low
nMDA receptor 1 38.60 Quite Low
Disease Link Frequency Relevance Heat
Stomach Cancer 116 99.84 Very High Very High Very High
Gastritis 14 99.28 Very High Very High Very High
Emphysema 1 99.20 Very High Very High Very High
Targeted Disruption 45 97.48 Very High Very High Very High
Cancer 130 92.64 High High
Hyperglycemia 1 88.28 High High
Congenital Anomalies 1 86.52 High High
Disease 19 84.32 Quite High
Metastasis 14 83.68 Quite High
Apoptosis 8 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, PDGFR-B and IGFBP-3) found to be overexpressed in gastric cancers relative to PN and AN (with the exception of CFD/Adipsin which was overexpressed in PN relative to gastric cancers and AN) were studied for their protein levels in tumour, corresponding PN and in AN tissues.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of IGFBP-3 associated with cancer and stomach cancer
1) Confidence 0.49 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 0.55 Pain Relevance 0
These mice over-express human IGFBP-3.
Positive_regulation (over-express) of Gene_expression (express) of IGFBP-3
2) Confidence 0.44 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.19 Pain Relevance 0.22
Increased Igfbp3 expression is associated with emphysema [32] and senescent fibroblasts, where it results in Igf1 sequestration and reduced cell proliferation [33,34].
Positive_regulation (Increased) of Gene_expression (expression) of Igfbp3 in fibroblasts associated with emphysema
3) Confidence 0.39 Published 2009 Journal Respir Res Section Body Doc Link PMC2770038 Disease Relevance 0.65 Pain Relevance 0.12
Overexpression of hmutIGFBP3, a mutant form that does not bind IGF, also reduces hypocretin peptide content in brainstem but not in hypothalamus suggesting both IGF dependent and independent effects on hypocretin transmission.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of hmutIGFBP3 in hypothalamus associated with medulla
4) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.64 Pain Relevance 0.05
Using IHC, IGFBP3 was found to be overexpressed in gastric cancers relative to the normal gastric tissue [40].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of IGFBP3 associated with stomach cancer
5) Confidence 0.08 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC3004887 Disease Relevance 1.17 Pain Relevance 0.10

General Comments

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