INT132997

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Context Info
Confidence 0.80
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 59
Total Number 61
Disease Relevance 45.90
Pain Relevance 17.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
neutrophils 12
lung 4
macrophages 3
fibroblasts 3
cleavage 2
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1320 100.00 Very High Very High Very High
Inflammation 1234 100.00 Very High Very High Very High
dexamethasone 410 100.00 Very High Very High Very High
dorsal root ganglion 9 99.76 Very High Very High Very High
Inflammatory stimuli 18 99.16 Very High Very High Very High
alcohol 8 98.84 Very High Very High Very High
Central nervous system 91 98.56 Very High Very High Very High
fibrosis 415 97.96 Very High Very High Very High
narcan 1 97.20 Very High Very High Very High
Inflammatory marker 26 97.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1428 100.00 Very High Very High Very High
Autoimmune Disease 17 99.92 Very High Very High Very High
Cancer 1196 99.84 Very High Very High Very High
Fibrosis 265 99.84 Very High Very High Very High
Acute Coronary Syndrome 17 99.84 Very High Very High Very High
Ganglion Cysts 9 99.76 Very High Very High Very High
Amyloid Plaque 24 99.64 Very High Very High Very High
Pulmonary Disease 749 99.62 Very High Very High Very High
Asthma 552 99.38 Very High Very High Very High
Stroke 172 99.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An alcohol extract of noni fruit puree also caused an inhibition of MMP-9 release from human monocytes after stimulation with LPS.
Localization (release) of MMP-9 in monocytes associated with alcohol
1) Confidence 0.80 Published 2010 Journal Phytother Res Section Abstract Doc Link 19548275 Disease Relevance 0.33 Pain Relevance 0.97
In rodents, MMP-2, MMP-3, MMP-9, MMP-13, MMP-14, as well as TIMP-1 and TIMP-2 are expressed in early stages of HSC activation and have been implicated in fibrogenesis as well as fibrolysis (reviewed in [20]).
Localization (implicated) of MMP-9 associated with fibrosis
2) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.89 Pain Relevance 0.31
This is consistent with another study, mentioned above, in which apocynin, an inhibitor of NADPH oxidase, also inhibited the release of MMP-9 and MMP-2 in SP-D -/- alveolar macrophages [23].
Localization (release) of MMP-9 in alveolar macrophages
3) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.30 Pain Relevance 0.21
It is, however, possible that this neutrophil influx and the large amounts of MMP-9 it releases have a protective effect against the development of pulmonary fibrosis.
Localization (releases) of MMP-9 in neutrophil associated with fibrosis and pulmonary fibrosis
4) Confidence 0.71 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.81 Pain Relevance 0.35
Measurement of MCP-1, ICAM-1, MMP-9 and oxLDL
Localization (Measurement) of MMP-9 associated with metalloproteinase
5) Confidence 0.70 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.09 Pain Relevance 0.09
This suggests that rapid MMP-9 release by mononuclear cells leads to an increase in serum levels of this protease postoperatively.
Localization (release) of MMP-9 in mononuclear cells
6) Confidence 0.67 Published 2005 Journal Surgical innovation Section Abstract Doc Link 16424954 Disease Relevance 0.05 Pain Relevance 0.13
and MMP-9 is closely related to ACS, which may be applied as a serology indicator in treatment of patients with coronary heart disease.
Localization (related) of MMP-9 in heart associated with acute coronary syndrome and coronary artery disease
7) Confidence 0.62 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 0.70 Pain Relevance 0.38
While MMP-9 is released primarily by inflammatory cells, MMP-2 is synthesized by structural cells including fibroblasts and endothelial and epithelial cells.
Localization (released) of MMP-9 in epithelial cells associated with inflammation
8) Confidence 0.62 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.59 Pain Relevance 0.46
Although a molar ratio appears to play a protective role against fibrotic changes, MMP-9 is considered primarily to be an inflammatory mediator released by leukocytes during acute inflammatory events to facilitate their progression across the basement membrane [30].
Localization (released) of MMP-9 in leukocytes associated with fibrosis and inflammation
9) Confidence 0.62 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 1.08 Pain Relevance 0.36
Correlation of serum MMP-9 concentrations with skin scores
Localization (Correlation) of serum MMP-9 in skin
10) Confidence 0.60 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 0.56 Pain Relevance 0
Doxycycline shown as a TTR fibril disrupter in vitro [9], when tested in transgenic TTR V30M mice, was capable of disaggregating amyloid deposits with concomitant decrease of metalloproteinase 9 (MMP-9), tissue inhibitor of metalloproteinase (TIMP-1), serum amyloid P component (SAP) and neutrophil gelatinase-associated lipocalin NGAL [10,11].
Localization (decrease) of MMP-9 in neutrophil associated with targeted disruption, alzheimer's dementia, metalloproteinase and amyloid plaque
11) Confidence 0.60 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.49 Pain Relevance 0.24
In vitro, MMP-9 is secreted from monocyte cell lines in response to stimulation by a number of TB components such as lipoarabinomannan (LAM), a process dependent upon the transcription factor AP-1 [19], [22].
Localization (secreted) of MMP-9 in monocyte associated with mycobacterial infection
12) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 0.85 Pain Relevance 0.36
Our data suggest that the majority of early CSF MMP-9 is released from neutrophils as there was a strong correlation between both baseline values.
Localization (released) of MMP-9 in neutrophils
13) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 1.30 Pain Relevance 0.22
Interestingly, our prior study revealed that SNP rs2664538, which is located within MMP9, is likely to be associated with acute PACG.
Localization (located) of MMP9 associated with glaucoma
14) Confidence 0.56 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2532703 Disease Relevance 0.70 Pain Relevance 0
Furthermore, Pycnogenol, an anti-inflammatory drug is able to attenuate signs of inflammation in asthma patients through reduction of MMP-9 secretion [21].
Localization (secretion) of MMP-9 associated with asthma and inflammation
15) Confidence 0.56 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.84 Pain Relevance 0.40
MMP-9 is quantitatively the most significant MMP released by macrophages and concentrations are increased in lungs and pleural fluid of TB patients [19], [20].
Localization (released) of MMP-9 in pleural fluid associated with mycobacterial infection
16) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 0.86 Pain Relevance 0.41
synergistically increases MMP-9 secretion from astrocytes, the most abundant CNS cell and a key component of the BBB [12].
Localization (secretion) of MMP-9 in astrocytes associated with central nervous system
17) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 1.31 Pain Relevance 0.46
There were significant correlations between CSF total protein (the only CSF analyte to fall significantly due to dexamethasone [2]) and MMP-9 (R2?
Localization (correlations) of MMP-9 associated with dexamethasone
18) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 0.15 Pain Relevance 0.17
Neutrophils release large amounts of preformed MMP-9 in response to many inflammatory stimuli, which may explain the lack of correlation observed between CSF MMP-9 and the pro-inflammatory cytokines measured [28].
Localization (release) of MMP-9 in Neutrophils associated with inflammation, cytokine and inflammatory stimuli
19) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 1.16 Pain Relevance 0.26
Neutrophils play a key but possibly under-recognized role in host defense to mycobacteria and release preformed MMP-9 from granzymes to cross the BBB [16], [17].
Localization (release) of MMP-9 in Neutrophils
20) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2748711 Disease Relevance 0.14 Pain Relevance 0.23

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