INT133004

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.63
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna3) transport (Chrna3) plasma membrane (Chrna3)
Anatomy Link Frequency
neurons 1
Chrna3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 98.98 Very High Very High Very High
IPN 2 98.44 Very High Very High Very High
Dorsal horn 2 94.96 High High
Spinal cord 3 94.48 High High
Inflammation 1 92.32 High High
Neurotransmitter 1 91.96 High High
analgesia 2 88.72 High High
medulla 1 88.52 High High
Pain 5 75.00 Quite High
Analgesic 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 2 98.78 Very High Very High Very High
Inflammatory Pain 2 98.44 Very High Very High Very High
Nociception 4 95.68 Very High Very High Very High
Pain 1 75.00 Quite High
Low Back Pain 1 25.00 Low Low
Spasticity 1 5.00 Very Low Very Low Very Low
Movement Disorders 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, inflammatory mediators specifically inhibit alpha3-containing GlyRs, and deletion of the murine alpha3 gene confers insensitivity to chronic inflammatory pain.
Gene_expression (deletion) of alpha3 associated with inflammatory mediators and ipn
1) Confidence 0.58 Published 2006 Journal Curr Opin Investig Drugs Section Abstract Doc Link 16425671 Disease Relevance 0.63 Pain Relevance 0.53
Although alpha subunits efficiently form homomeric GlyRs in recombinant expression systems, homomeric alpha1, alpha3 and alpha4 GlyRs are weakly expressed in adult neurons.
Gene_expression (expressed) of alpha3 in neurons
2) Confidence 0.06 Published 2009 Journal Neuropharmacology Section Abstract Doc Link 18721822 Disease Relevance 0 Pain Relevance 0.13

General Comments

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