INT133018

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2006
Negated 2
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.47
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngfr) nuclear envelope (Ngfr) Golgi apparatus (Ngfr)
plasma membrane (Ngfr) nucleus (Ngfr) cytoplasm (Ngfr)
Anatomy Link Frequency
neurons 4
dorsal root ganglia 2
Ngfr (Mus musculus)
Pain Link Frequency Relevance Heat
c fibre 1 99.90 Very High Very High Very High
substance P 1 99.80 Very High Very High Very High
Nerve growth factor 7 97.90 Very High Very High Very High
hypoalgesia 1 86.72 High High
diabetic neuropathy 3 82.12 Quite High
induced neuropathy 1 75.36 Quite High
Spinal cord 10 5.00 Very Low Very Low Very Low
Sciatic nerve 6 5.00 Very Low Very Low Very Low
lumbar region 6 5.00 Very Low Very Low Very Low
Pain threshold 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 46 99.18 Very High Very High Very High
Targeted Disruption 8 97.64 Very High Very High Very High
Disease 5 97.02 Very High Very High Very High
Nociception 32 96.92 Very High Very High Very High
Neurodegenerative Disease 8 90.32 High High
Hypoalagesia 1 86.72 High High
Diabetic Neuropathy 3 82.12 Quite High
Herpes Simplex Virus 1 76.56 Quite High
Neuropathic Pain 1 75.36 Quite High
Cold Sores 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, these results show that cell death observed in Necdin mutant DRGs does not affect specifically the p75NTR-expressing neurons and consequently does not directly involve the p75NTR-signalling pathway.


Neg (not) Regulation (affect) of Gene_expression (neurons) of p75NTR-expressing in neurons associated with death
1) Confidence 0.43 Published 2006 Journal BMC Dev Biol Section Body Doc Link PMC1687209 Disease Relevance 0.10 Pain Relevance 0
Once the disease progressed into its more severe stages, NGF, although still capable of altering the electrophysiological profile of the sensory A- and C-fibers and influencing the expression of p75 and substance P in the dorsal root ganglia, could no longer maintain normal nociception.
Regulation (influencing) of Gene_expression (expression) of p75 in dorsal root ganglia associated with nociception, c fibre, nerve growth factor, disease and substance p
2) Confidence 0.28 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16427624 Disease Relevance 0.81 Pain Relevance 0.70
Unexpectedly, Necdin loss of function has no effect on p75NTR expressing neurons suggesting no direct genetic interaction between Necdin and P75NTR in this context.
Neg (no) Regulation (effect) of Gene_expression (expressing) of p75NTR in neurons
3) Confidence 0.26 Published 2006 Journal BMC Dev Biol Section Abstract Doc Link PMC1687209 Disease Relevance 0.56 Pain Relevance 0

General Comments

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