INT133028

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Context Info
Confidence 0.73
First Reported 2003
Last Reported 2011
Negated 1
Speculated 8
Reported most in Body
Documents 209
Total Number 218
Disease Relevance 131.92
Pain Relevance 36.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
Anatomy Link Frequency
monocytes 25
alveolar macrophages 21
macrophages 12
T cells 12
keratinocytes 5
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 491 100.00 Very High Very High Very High
COX2 6 100.00 Very High Very High Very High
cytokine 3111 99.92 Very High Very High Very High
Arthritis 765 99.84 Very High Very High Very High
psoriasis 175 99.72 Very High Very High Very High
spinal inflammation 564 99.70 Very High Very High Very High
rheumatoid arthritis 1305 99.68 Very High Very High Very High
Inflammation 2212 99.54 Very High Very High Very High
ischemia 52 98.86 Very High Very High Very High
Central nervous system 68 98.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 325 99.96 Very High Very High Very High
Rheumatoid Arthritis 1727 99.84 Very High Very High Very High
Nicotine Addiction 1440 99.84 Very High Very High Very High
Pulmonary Disease 824 99.84 Very High Very High Very High
Death 103 99.82 Very High Very High Very High
Psoriasis 247 99.72 Very High Very High Very High
Syndrome 236 99.72 Very High Very High Very High
Low Back Pain 564 99.70 Very High Very High Very High
Malaria 170 99.70 Very High Very High Very High
Disease 1667 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of TLR2, TLR4 and CD14 on AM and autologous monocytes was determined using a fluorescence activated cell sorter (FACS) Calibur (Becton Dickinson, Heidelberg, Germany).
Spec (determined) Gene_expression (expression) of TLR2 in monocytes
1) Confidence 0.73 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0 Pain Relevance 0
Thus, the blunted TLR2 expression of AM from smokers and COPD patients after LPS stimulation may impair antimicrobial defenses in the lower respiratory tract.
Gene_expression (expression) of TLR2 in lower respiratory tract associated with pulmonary disease and nicotine addiction
2) Confidence 0.73 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.77 Pain Relevance 0.07
It is tempting to speculate that this phenomenon also plays a role under conditions of chronic stimulation with bacterial components in vivo as suggested by the missing effect of LPS-stimulation on TLR2 expression on cells from smokers and COPD patients.
Gene_expression (expression) of TLR2 associated with pulmonary disease and nicotine addiction
3) Confidence 0.73 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.83 Pain Relevance 0.03
Our data demonstrating an altered AM phenotype with reduced expression of TLR2 in smokers and COPD patients suggest that a continuous exposure to microbial products in this disease provided by bacterial colonization and LPS present in tobacco smoke [5] may downmodulate the pulmonary immune response.
Gene_expression (expression) of TLR2 associated with pulmonary disease, nicotine addiction and disease
4) Confidence 0.73 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.60 Pain Relevance 0.26
Comparing AM from non-smokers (A and B), smokers and COPD patients we detected a markedly lower expression of TLR2 on AM from smokers and COPD patients (13.98 ± 2.54 and 12.07 ± 3.5 [nonsmoker groups] vs. 6.59 ± 1.42 and 6.08 ± 1.5 rMFI, respectively, p < 0.01) (figure 2a).
Gene_expression (expression) of TLR2 associated with pulmonary disease and nicotine addiction
5) Confidence 0.73 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.40 Pain Relevance 0
In contrast, cells of smokers and COPD patients did not respond to LPS stimulation with increased TLR2 expression (7.09 ± 1.42 vs. 6.59 ± 1.42 rMFI [smokers], p = n.s.; 6.63 ± 2.40 vs. 6.24 ± 1.71 rMFI, [COPD patients], p = n.s.)
Gene_expression (expression) of TLR2 associated with pulmonary disease and nicotine addiction
6) Confidence 0.73 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.18 Pain Relevance 0
The main finding was that AM from COPD patients and smokers show an equally decreased surface expression of TLR2 compared to non-smokers of two age groups.
Gene_expression (expression) of TLR2 associated with nicotine addiction and pulmonary disease
7) Confidence 0.73 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.98 Pain Relevance 0
In contrast Lauener et al. demonstrated a significantly increased expression of CD14 and TLR2 on blood cells of farmers' children compared to non-farmers' children [31].
Gene_expression (expression) of TLR2 in blood cells
8) Confidence 0.73 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.28 Pain Relevance 0.03
An increased TLR2 surface expression on human monocytes in response to LPS-stimulation has been described previously [13], whereas on the transcriptional level divergent data have been reported showing either upregulation [14,15], or downregulation [16,17] of TLR2-mRNA depending on timing and dose of stimulation.
Gene_expression (expression) of TLR2 in monocytes
9) Confidence 0.73 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.88 Pain Relevance 0.03
Expression levels of TLR2, TLR4 and TLR9 were monitored by flow cytometry in the transition process from monocytes to monocyte-derived macrophages.
Gene_expression (Expression) of TLR2 in macrophages
10) Confidence 0.71 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0
The expression of TLR2, TLR4 and TLR9 mRNA of alveolar macrophages was lower than that of autologous monocytes (Figure 3A).
Gene_expression (expression) of TLR2 in monocytes
11) Confidence 0.71 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0
For example, human peripheral blood monocytes and macrophages from lung tissue or colon express TLR1, TLR2, TLR3, TLR4 and TLR5 [20], whereas gut epithelial cells express TLR3 and TLR5 only [21].
Gene_expression (express) of TLR2 in epithelial cells
12) Confidence 0.71 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.74 Pain Relevance 0.10
Reverse transcription and real-time PCR for TLR2, TLR4 and TLR9 gene expression
Gene_expression (expression) of TLR2
13) Confidence 0.71 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.07 Pain Relevance 0
Interestingly, the low TLR2 expression levels on monocyte-derived macrophages on day seven coincided with the low constitutive TLR2 expression found on alveolar macrophages (Figures 1 and 2).
Gene_expression (expression) of TLR2 in alveolar macrophages
14) Confidence 0.71 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.09 Pain Relevance 0
Alveolar macrophages expressed lower levels of TLR2, comparable levels of TLR4, and higher levels of TLR9 than monocytes.
Gene_expression (expressed) of TLR2 in Alveolar macrophages
15) Confidence 0.71 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.45 Pain Relevance 0
The same study found that TLR3 and TLR5 were expressed exclusively on alveolar macrophages and that TLR2 and IL-4 expression were inversely correlated.
Gene_expression (expression) of TLR2 in alveolar macrophages
16) Confidence 0.71 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.45 Pain Relevance 0
To assess the expression of TLR2, TLR4 and TLR9 by flow cytometry following ligand exposure, alveolar macrophages and monocytes were stimulated for the optimal incubation periods (described in the Methods section) with Pam3Cys (30 minutes), LPS (10 minutes) and M.tb DNA (24 hours), respectively.
Gene_expression (expression) of TLR2 in alveolar macrophages associated with mycobacterial infection
17) Confidence 0.71 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.09 Pain Relevance 0
Interestingly, the low TLR2 expression levels on monocyte-derived macrophages on day seven coincided with the low constitutive TLR2 expression found on alveolar macrophages (Figures 1 and 2).
Gene_expression (expression) of TLR2 in alveolar macrophages
18) Confidence 0.71 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.09 Pain Relevance 0
TLR2 expression is modified during the monocyte differentiation process
Gene_expression (expression) of TLR2 in monocyte
19) Confidence 0.71 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0
Tissue compartment-specific immune responses thus may be characterized by differential expression levels of TLRs, such as those shown here for TLR2, that result in distinct production levels of cytokines.
Gene_expression (expression) of TLR2 associated with cytokine
20) Confidence 0.71 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.28 Pain Relevance 0.27

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