INT133029

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 18
Total Number 21
Disease Relevance 11.31
Pain Relevance 2.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
Anatomy Link Frequency
nasal mucosa 2
macrophages 1
monocytes 1
alveolar macrophages 1
myeloid cell 1
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 1 100.00 Very High Very High Very High
agonist 17 99.96 Very High Very High Very High
Inflammatory response 78 99.36 Very High Very High Very High
cytokine 196 98.44 Very High Very High Very High
Inflammation 237 98.06 Very High Very High Very High
Inflammatory mediators 15 96.76 Very High Very High Very High
pulpitis 2 92.84 High High
Infliximab 5 92.08 High High
imagery 28 89.44 High High
corticosteroid 11 89.32 High High
Disease Link Frequency Relevance Heat
Atherosclerosis 94 99.84 Very High Very High Very High
Rhinitis 103 99.48 Very High Very High Very High
Diabetes Mellitus 45 99.42 Very High Very High Very High
INFLAMMATION 332 99.18 Very High Very High Very High
Death 20 99.12 Very High Very High Very High
Pulmonary Disease 42 97.36 Very High Very High Very High
Nicotine Addiction 66 97.00 Very High Very High Very High
Viral Infection 11 96.16 Very High Very High Very High
Cold Sores 367 95.08 Very High Very High Very High
Hypersensitivity 132 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that TLR2 may be differentially regulated in monocytes and alveolar macrophages.
Spec (may) Regulation (regulated) of TLR2 in monocytes
1) Confidence 0.56 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0.14
Data shown in this setting demonstrate that genes involved in TLR-mediated pathway are significantly up-regulated in intermediate or advanced lesions, including TLR1, TLR2, TLR7, and MyD88.
Regulation (regulated) of TLR2
2) Confidence 0.36 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 0.82 Pain Relevance 0.11
g/ml PGN (target TLR2 homodimer), 25 ?
Regulation (target) of TLR2
3) Confidence 0.36 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
The data on HO-1, TLR2, TLR4, and TNF-?
Regulation (data) of TLR2
4) Confidence 0.29 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.15 Pain Relevance 0
The expressions of the pattern recognition receptors (PRRs) TLR2 and TLR4 were measured by quantitative RT-PCR, pro-inflammatory cytokines IL-1alpha, IL-8 and TNF-alpha were monitored by quantitative RT-PCR and by ELISA, and alterations in TLR2 protein level were measured by flow cytometry.
Regulation (alterations) of TLR2 associated with inflammation and cytokine
5) Confidence 0.26 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16428071 Disease Relevance 0.44 Pain Relevance 0.32
This finding was confirmed using in situ hybridization targeting TLR2, which was recently demonstrated by our group on AM and alveolar epithelial cells type II in the human lung [12].
Regulation (targeting) of TLR2 in lung
6) Confidence 0.26 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.91 Pain Relevance 0.03
While TLR2 regulation may be due to Pam3Cys ligation and/or cytokine production from macrophages or other cellular subsets within the bronchoalveolar cells (5-8% are lymphocytes), regulation of TLR4 expression may result from a direct effect of LPS on the cell membrane as it was noted already within 10 minutes of LPS stimulation.
Regulation (regulation) of TLR2 in macrophages associated with cytokine
7) Confidence 0.25 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.07 Pain Relevance 0.15
Furthermore, since TLR9 is also involved in the pathogenesis of autoimmune mechanisms related to type 1 diabetes in experimental animals and TLR2 is involved in ?
Regulation (involved) of TLR2 associated with diabetes mellitus
8) Confidence 0.24 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 1.30 Pain Relevance 0.04
Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis

Background

Regulation (regulation) of Toll-like receptors 2 associated with rhinitis
9) Confidence 0.23 Published 2005 Journal Respir Res Section Title Doc Link PMC1243240 Disease Relevance 0.40 Pain Relevance 0
An up-regulation of TLR2, TLR3 and TLR4 in the nasal mucosa of patients with symptomatic allergic rhinitis supports the idea of a role for TLRs in allergic inflammation.
Regulation (regulation) of TLR2 in nasal mucosa associated with rhinitis, inflammation and hypersensitivity
10) Confidence 0.23 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 1.24 Pain Relevance 0.21
The up-regulation of Toll-like receptors 2, 3 and 4 in the nasal mucosa of patients with symptomatic allergic rhinitis supports the idea of a role for Toll-like receptors in allergic airway inflammation.



Regulation (regulation) of Toll-like receptors 2 in nasal mucosa associated with rhinitis, inflammation and hypersensitivity
11) Confidence 0.23 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1243240 Disease Relevance 0.53 Pain Relevance 0.05
TLR1 and TLR2 have been previously reported to be significantly regulated in atherosclerosis and their functional roles have been widely investigated in atherosclerosis [29,30].
Regulation (regulated) of TLR2 associated with atherosclerosis
12) Confidence 0.22 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2529314 Disease Relevance 0.83 Pain Relevance 0.10
IL6 is discussed above and TLR2 is not a drug target.
Neg (not) Regulation (target) of TLR2
13) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0 Pain Relevance 0.04
Importantly, the generation of CD1b+ DCs appears to be dependent on signaling through TLR2/1 [48].
Spec (appears) Regulation (dependent) of TLR2
14) Confidence 0.20 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2330092 Disease Relevance 0.20 Pain Relevance 0
These findings suggest that TLR2 may be differentially regulated in monocytes and alveolar macrophages.
Spec (may) Regulation (regulated) of TLR2 in alveolar macrophages
15) Confidence 0.19 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0.14
PU.1 is a member of the ets gene family and is a master switch in the regulation of an array of genes involved in myeloid cell activation and differentiation, including TLR2, -4, and -9 (17,18).
Regulation (regulation) of TLR2 in myeloid cell
16) Confidence 0.14 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518353 Disease Relevance 1.10 Pain Relevance 0.10
Viral or host glycoproteins/lipopeptides responsible for TLR2 agonist activity are currently unknown.
Regulation (responsible) of TLR2 associated with agonist
17) Confidence 0.11 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.34 Pain Relevance 0.16
Roles of TLR2, TLR4, NOD2, and NOD1 in pulp fibroblasts.
Regulation (Roles) of TLR2 in fibroblasts associated with cox2
18) Confidence 0.11 Published 2009 Journal J. Dent. Res. Section Title Doc Link 19734466 Disease Relevance 0.51 Pain Relevance 0.55
All patients' PMNs had a normal shedding response to S. aureus peptidoglycan (PGN) (TLR2 and other receptors).
Regulation (response) of TLR2
19) Confidence 0.10 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.06 Pain Relevance 0.18
No effect of forced HO-1 expression on TLR2 and TLR4 mRNA in human PBMCs
Neg (No) Regulation (effect) of TLR2
20) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.16 Pain Relevance 0.05

General Comments

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