INT13303

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 1986
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 40
Total Number 48
Disease Relevance 16.27
Pain Relevance 11.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)
signal transducer activity (PTAFR)
Anatomy Link Frequency
platelet 9
lumen 3
IEC-6 2
muscle 2
ileum 1
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 53 100.00 Very High Very High Very High
qutenza 67 99.92 Very High Very High Very High
substance P 170 99.90 Very High Very High Very High
Potency 105 99.44 Very High Very High Very High
Nicotine 4 99.38 Very High Very High Very High
cytokine 289 99.26 Very High Very High Very High
Inflammation 699 99.06 Very High Very High Very High
Inflammatory mediators 130 98.60 Very High Very High Very High
antagonist 201 98.52 Very High Very High Very High
Multiple sclerosis 83 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neonatal Necrotizing Enterocolitis 612 99.98 Very High Very High Very High
Targeted Disruption 6 99.76 Very High Very High Very High
Disease 123 99.26 Very High Very High Very High
Injury 220 99.12 Very High Very High Very High
INFLAMMATION 806 99.06 Very High Very High Very High
Duodenal Ulcer 6 98.76 Very High Very High Very High
Endotoxemia 19 98.64 Very High Very High Very High
Esophageal Disease 132 98.52 Very High Very High Very High
Increased Venous Pressure Under Development 140 98.32 Very High Very High Very High
Neurogenic Inflammation 14 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific factors which stabilize PAF and/or regulate PAF activity in body fluids are largely unknown.
Positive_regulation (stabilize) of PAF in body
1) Confidence 0.69 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 3947392 Disease Relevance 0.20 Pain Relevance 0.08
However, the PI response diminished significantly relative to the maximal response when the concentration of PAF was increased to 1–10 µM (Figure 1A).
Positive_regulation (increased) of PAF
2) Confidence 0.67 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0 Pain Relevance 0.82
Future experiments will elucidate the exact mechanisms of STAT3 involvement, and possibly other factors, in PAF mediated transcriptional activation of TLR4 and will investigate experimental models where PAF is neutralized.
Positive_regulation (activation) of PAF
3) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.47 Pain Relevance 0.16
PMA at a non-stimulatory concentration (2 ng/ml) potentiated the effect of fMet-Leu-Phe but did not induce responsiveness to PAF, ATP or beta-endorphin.
Neg (not) Positive_regulation (induce) of PAF
4) Confidence 0.64 Published 1989 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 2552328 Disease Relevance 0 Pain Relevance 1.15
PAF levels increased in the HCl-filled mucosal sac and in its supernatant when compared to controls (Krebs filled mucosal sac at pH 7.4) (Fig. 5).
Positive_regulation (increased) of PAF
5) Confidence 0.51 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.07 Pain Relevance 0.51
Impedance aggregometry was used to evaluate the potency of anti-platelet agents on Platelet Activating Factor (PAF)--induced platelet aggregation in citrated human whole blood.
Positive_regulation (--induced) of PAF in platelet associated with potency
6) Confidence 0.50 Published 1991 Journal Prostaglandins Section Abstract Doc Link 1665568 Disease Relevance 0 Pain Relevance 0.18
Impedance aggregometry was used to evaluate the potency of anti-platelet agents on Platelet Activating Factor (PAF)--induced platelet aggregation in citrated human whole blood.
Positive_regulation (--induced) of Platelet Activating Factor in platelet associated with potency
7) Confidence 0.50 Published 1991 Journal Prostaglandins Section Abstract Doc Link 1665568 Disease Relevance 0 Pain Relevance 0.18
The influence of physiological concentrations of platelet-activating factor on colonic epithelial anion secretion and increased permeability in rabbit distal colon is indirect and consistent with mediation by prostaglandins released from mucosal mast cells.
Positive_regulation (concentrations) of platelet-activating factor
8) Confidence 0.50 Published 1995 Journal Clin. Sci. Section Abstract Doc Link 7705001 Disease Relevance 0 Pain Relevance 0.07
PAF receptor agonists stimulated [Ca2+]i mobilization in these cells in a concentration-dependent and antagonist-reversible manner.
Positive_regulation (stimulated) of PAF receptor associated with antagonist and agonist
9) Confidence 0.48 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0.15 Pain Relevance 0.19
Since initial studies indicated that some HCECs responded to PAF by exhibiting an apparent oscillatory [Ca2+]i mobilization pattern (Figure 2D), a more extensive evaluation of this phenomenon was investigated.
Positive_regulation (responded) of PAF
10) Confidence 0.48 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0 Pain Relevance 0.10
PAF levels remained elevated through the second (746.8 +/- 82.95), fourth (700.6 +/- 34.93) and sixth hours (644.4 +/- 42.85), and then decreased at the end of the attack, reaching levels significantly lower than those measured at the time of catheter insertion (565.5 +/- 38.34).
Positive_regulation (elevated) of PAF
11) Confidence 0.47 Published 2004 Journal Cephalalgia Section Abstract Doc Link 15265050 Disease Relevance 0.73 Pain Relevance 0.57
We first wished to verify that PAF stimulation activated STAT3 in IEC, as was shown before in COS-7 cells.
Positive_regulation (stimulation) of PAF
12) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
These data suggest that although TLR4 is weakly expressed on the surface of IEC, platelet activating factor stimulation upregulates expression of the receptor.
Positive_regulation (stimulation) of platelet activating factor in platelet
13) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.14 Pain Relevance 0.08
To further demonstrate the effects of PAF on STAT3 in intestinal epithelial cells, STAT3 and phospho-STAT3 Western blots were performed on cytoplasmic and nuclear fractions of IEC-6 cells, following PAF stimulation.
Positive_regulation (stimulation) of PAF in IEC-6
14) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
To determine whether or not the increased mRNA of IEC following PAF stimulation leads to a corresponding increase in TLR4 protein expression, immunohistochemistry was performed.
Spec (whether) Positive_regulation (following) of PAF
15) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.08 Pain Relevance 0
To further address the potential mechanism of PAF-induced TLR4 upregulation, we pretreated IEC-6 cells with inhibitors of STAT3 and NF-?
Positive_regulation (upregulation) of PAF-induced in IEC-6
16) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
We show that perfusion of PAF in the lumen of the ileum in this experimental model results in an increase of TLR4 expression in mucosal scrapings that is not seen either in the mucosa of sham-perfused animals or in the mucosa outside of the perfused loop either in the PAF-perfused or sham perfused animals.
Positive_regulation (increase) of PAF-perfused in ileum
17) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.47 Pain Relevance 0
PAF caused a translocation of STAT3 from the cytosol to the nuclei of enterocytes and the PAF-induced induction of TLR4 expression was inhibited by pharmacological inhibition of the STAT3 and NFkB signaling pathways.


Positive_regulation (induction) of PAF-induced in enterocytes
18) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.69 Pain Relevance 0.14
These results indicate that stimulation with PAF activates STAT3, a transcription factor that may be involved in TLR4 transcriptional regulation.


Positive_regulation (stimulation) of PAF
19) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
Our data suggest that capsaicin exerts its anti-inflammatory effect by inhibiting SOCE elicited via PLC activation, which occurs upon PAF activation and results in the subsequent superoxide production.
Positive_regulation (activation) of PAF associated with inflammation and qutenza
20) Confidence 0.44 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11034409 Disease Relevance 0.10 Pain Relevance 0.94

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox