INT133030

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2011
Negated 6
Speculated 0
Reported most in Body
Documents 53
Total Number 53
Disease Relevance 38.15
Pain Relevance 10.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
Anatomy Link Frequency
T cells 14
keratinocytes 8
alveolar macrophages 6
monocytes 4
basal layer 4
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 165 100.00 Very High Very High Very High
spinal inflammation 221 99.90 Very High Very High Very High
cytokine 691 99.84 Very High Very High Very High
psoriasis 116 99.72 Very High Very High Very High
Inflammation 667 99.30 Very High Very High Very High
rheumatoid arthritis 502 99.10 Very High Very High Very High
Arthritis 249 98.92 Very High Very High Very High
Osteoarthritis 21 97.16 Very High Very High Very High
chemokine 101 96.76 Very High Very High Very High
depression 4 95.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypersensitivity 97 99.96 Very High Very High Very High
Low Back Pain 221 99.90 Very High Very High Very High
Malaria 165 99.90 Very High Very High Very High
Oral Lichen Planus 6 99.84 Very High Very High Very High
INFLAMMATION 775 99.76 Very High Very High Very High
Psoriasis 164 99.72 Very High Very High Very High
Nicotine Addiction 548 99.68 Very High Very High Very High
Disease 386 99.68 Very High Very High Very High
Critical Illness 37 99.60 Very High Very High Very High
Burning Mouth Syndrome 6 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increased TLR2 surface expression on human monocytes in response to LPS-stimulation has been described previously [13], whereas on the transcriptional level divergent data have been reported showing either upregulation [14,15], or downregulation [16,17] of TLR2-mRNA depending on timing and dose of stimulation.
Positive_regulation (increased) of Gene_expression (expression) of TLR2 in monocytes
1) Confidence 0.65 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.88 Pain Relevance 0.03
In contrast Lauener et al. demonstrated a significantly increased expression of CD14 and TLR2 on blood cells of farmers' children compared to non-farmers' children [31].
Positive_regulation (increased) of Gene_expression (expression) of TLR2 in blood cells
2) Confidence 0.65 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.29 Pain Relevance 0.03
In contrast, cells of smokers and COPD patients did not respond to LPS stimulation with increased TLR2 expression (7.09 ± 1.42 vs. 6.59 ± 1.42 rMFI [smokers], p = n.s.; 6.63 ± 2.40 vs. 6.24 ± 1.71 rMFI, [COPD patients], p = n.s.)
Positive_regulation (increased) of Gene_expression (expression) of TLR2 associated with pulmonary disease and nicotine addiction
3) Confidence 0.65 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.29 Pain Relevance 0
Thus, the blunted TLR2 expression of AM from smokers and COPD patients after LPS stimulation may impair antimicrobial defenses in the lower respiratory tract.
Positive_regulation (blunted) of Gene_expression (expression) of TLR2 in lower respiratory tract associated with pulmonary disease and nicotine addiction
4) Confidence 0.65 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.77 Pain Relevance 0.07
Pam3Cys induced TLR2 mRNA expression was increased as early as after 1 h in both cells types, but was maintained for a longer time in bronchoalveolar cells.
Positive_regulation (increased) of Gene_expression (expression) of TLR2 mRNA
5) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0.11
g/ml) which led to an increased expression of TLR2 on AM from non-smokers (18.35 ± 4.24 vs. 13.98 ± 2.54 rMFI [A] p < 0.04; 21.1 ± 6.23 vs. 12.07 ± 3.5 [B] p < 0.04).
Positive_regulation (increased) of Gene_expression (expression) of TLR2 associated with nicotine addiction
6) Confidence 0.47 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.22 Pain Relevance 0
In contrast, cells of smokers and COPD patients did not respond to LPS stimulation with increased TLR2 expression (7.09 ± 1.42 vs. 6.59 ± 1.42 rMFI [smokers], p = n.s.; 6.63 ± 2.40 vs. 6.24 ± 1.71 rMFI, [COPD patients], p = n.s.)
Positive_regulation (increased) of Gene_expression (expression) of TLR2 associated with pulmonary disease and nicotine addiction
7) Confidence 0.47 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 1.29 Pain Relevance 0
It is tempting to speculate that this phenomenon also plays a role under conditions of chronic stimulation with bacterial components in vivo as suggested by the missing effect of LPS-stimulation on TLR2 expression on cells from smokers and COPD patients.
Positive_regulation (stimulation) of Gene_expression (expression) of TLR2 associated with pulmonary disease and nicotine addiction
8) Confidence 0.47 Published 2005 Journal Respir Res Section Body Doc Link PMC1187924 Disease Relevance 0.83 Pain Relevance 0.03
Pam3Cys induced TLR2 mRNA expression was increased as early as after 1 h in both cells types, but was maintained for a longer time in bronchoalveolar cells.
Positive_regulation (increased) of Gene_expression (expression) of TLR2 mRNA
9) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0.11
TLR2 cell surface expression by flow cytometry was decreased on monocytes after stimulation with Pam3Cys, whereas the expression of TLR2 on alveolar macrophages in response to Pam3Cys remained unchanged.
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of TLR2 in alveolar macrophages
10) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0.09
Our observation of reduced TLR2 surface expression on alveolar macrophages coincides functionally with the lower production of TNF-?
Positive_regulation (observation) of Gene_expression (expression) of TLR2 in alveolar macrophages
11) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.07 Pain Relevance 0.03
Pam3Cys induced TLR2 mRNA expression was increased as early as after 1 h in both cells types, but was maintained for a longer time in bronchoalveolar cells.
Positive_regulation (maintained) of Gene_expression (expression) of TLR2 mRNA
12) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0.11
Pam3Cys upregulated the expression of TLR2 mRNA in monocytes within a 1-hour incubation period only, whereas in alveolar macrophages TLR2 mRNA upregulation was detected after 1 h and then maintained until 24 h (Figure 5A).
Positive_regulation (upregulated) of Gene_expression (expression) of TLR2 mRNA in alveolar macrophages
13) Confidence 0.46 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.40 Pain Relevance 0.03
This increase in TLR2 mRNA expression was also detectable at the protein level in LPS-stimulated cells.
Positive_regulation (increase) of Gene_expression (expression) of TLR2 mRNA
14) Confidence 0.45 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16428071 Disease Relevance 0.49 Pain Relevance 0.30
The amount of TNF-alpha mRNA was diminished in unstimulated keratinocytes, while TLR2 mRNA expression was markedly enhanced both in unstimulated and LPS-treated cells after incubation with budesonide.
Positive_regulation (enhanced) of Gene_expression (expression) of TLR2 mRNA in keratinocytes
15) Confidence 0.45 Published 2006 Journal Int. Immunopharmacol. Section Abstract Doc Link 16428071 Disease Relevance 0.50 Pain Relevance 0.31
In addition TLR2 mRNA and protein expression was increased after LPS stimulation on non-smokers AM in contrast to smokers and COPD patients.


Positive_regulation (increased) of Gene_expression (expression) of TLR2 mRNA associated with pulmonary disease and nicotine addiction
16) Confidence 0.44 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1187924 Disease Relevance 1.54 Pain Relevance 0.03
The increased expression of TLR2, TLR3 and TLR4 as a consequence of allergen exposure is in line with a previous report demonstrating an increase of TLR2 protein in chronic middle ear inflammation [26].
Positive_regulation (increased) of Gene_expression (expression) of TLR2 in middle ear associated with otitis media and inflammation
17) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.44 Pain Relevance 0.10
patients with ankylosing spondylitis and increased expression of TLR2 and TLR4
Positive_regulation (increased) of Gene_expression (expression) of TLR2 associated with spinal inflammation
18) Confidence 0.41 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 1.63 Pain Relevance 0.76
Our results suggest that the levels of sCD14 and sTLR-2 in UWS were upregulated in OLP and BMS respectively.
Positive_regulation (upregulated) of Gene_expression (levels) of sTLR-2 in UWS associated with oral lichen planus and burning mouth syndrome
19) Confidence 0.40 Published 2008 Journal Clin. Immunol. Section Abstract Doc Link 17916440 Disease Relevance 1.21 Pain Relevance 0.08
Expression of TLR2 and TLR4 has been shown to be increased in the synovial tissue of RA patients compared with healthy donors or osteoarthritis samples [108], [109].
Positive_regulation (increased) of Gene_expression (Expression) of TLR2 associated with osteoarthritis and arthritis
20) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.92 Pain Relevance 0.38

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