INT133046

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Context Info
Confidence 0.54
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.23
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF, NFKB1) nucleoplasm (NFKB1) mitochondrion (NFKB1)
intracellular (TNF) extracellular matrix organization (TNF) cytoplasm (NFKB1)
TNF (Homo sapiens)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 14 96.72 Very High Very High Very High
cINOD 3 95.68 Very High Very High Very High
agonist 4 94.08 High High
Snapping jaw 4 88.52 High High
Pain 1 82.16 Quite High
cytokine 4 75.00 Quite High
melanocortin 1 receptor 2 75.00 Quite High
dexamethasone 1 33.60 Quite Low
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Skin Cancer 15 98.60 Very High Very High Very High
INFLAMMATION 15 96.72 Very High Very High Very High
Cancer 3 95.84 Very High Very High Very High
Necrosis 3 95.56 Very High Very High Very High
Metastasis 2 91.12 High High
Temporomandibular Joint Syndrome 4 88.52 High High
Synovitis 1 82.72 Quite High
Arthralgia 1 82.16 Quite High
Adhesions 3 81.04 Quite High
Stress 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BMS-470539 dose-dependently inhibited TNF-alpha-induced activation of a NF-kappaB transcriptional reporter in human melanoma cells, which endogenously express MC-1R.
TNF-alpha Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB associated with skin cancer
1) Confidence 0.54 Published 2006 Journal J. Leukoc. Biol. Section Abstract Doc Link 16888084 Disease Relevance 0.42 Pain Relevance 0.40
Electrophoretic mobility shift assay (EMSA) revealed that transient NF-kappaB activation in the COX-2 promoter was triggered by TNF-alpha.
TNF-alpha Positive_regulation (triggered) of Positive_regulation (activation) of NF-kappaB
2) Confidence 0.41 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 17384033 Disease Relevance 0.59 Pain Relevance 0.39
In conclusion, sodium salicylate effectively inhibited TNF-alpha-induced upregulation of NF-kappaB, ICAM-1 expression, in-vitro migration and invasion in human melanoma cells, indicating that non-steroidal anti-inflammatory drugs may be a useful therapeutic approach to oppose inflammation-induced melanoma invasion and metastasis in vivo.
TNF-alpha Positive_regulation (induced) of Positive_regulation (upregulation) of NF-kappaB associated with inflammation, cinod, skin cancer and metastasis
3) Confidence 0.38 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.90 Pain Relevance 0.14
Sodium salicylate inhibits TNF-alpha-induced NF-kappaB activation, cell migration, invasion and ICAM-1 expression in human melanoma cells.
TNF-alpha Positive_regulation (induced) of Positive_regulation (activation) of NF-kappaB associated with skin cancer
4) Confidence 0.38 Published 2006 Journal Melanoma Res. Section Title Doc Link 16432451 Disease Relevance 0.74 Pain Relevance 0.04
High concentrations of NAC and mito-Q instead caused glutathionylation of IKKalpha, thereby inhibiting its activity that in turn enhanced the downstream NF-kappaB activation and ICAM-1 expression by TNF-alpha.
TNF-alpha Positive_regulation (enhanced) of Positive_regulation (activation) of NF-kappaB
5) Confidence 0.25 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.58 Pain Relevance 0.21

General Comments

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