INT133049

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Context Info
Confidence 0.47
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.49
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, ICAM1) plasma membrane (TNF, ICAM1) signal transduction (TNF)
extracellular region (TNF) cell adhesion (ICAM1) intracellular (TNF)
TNF (Homo sapiens)
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 13 100.00 Very High Very High Very High
cINOD 5 96.00 Very High Very High Very High
cytokine 23 68.16 Quite High
COX2 10 5.00 Very Low Very Low Very Low
dexamethasone 2 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 17 100.00 Very High Very High Very High
Skin Cancer 7 97.84 Very High Very High Very High
Metastasis 3 91.44 High High
Cancer 75 79.68 Quite High
Stress 6 79.56 Quite High
Adhesions 3 75.00 Quite High
Injury 1 72.88 Quite High
Targeted Disruption 10 62.00 Quite High
Squamous Cell Carcinoma 8 38.72 Quite Low
Necrosis 1 36.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study further addressed that IkappaB kinase (IKK), a phosphorylation-dependent regulator of NF-kappaB, plays an important regulatory role in the TNF-alpha-mediated induction of the inflammatory cell surface molecule ICAM-1.
TNF-alpha Positive_regulation (induction) of ICAM-1 associated with inflammation
1) Confidence 0.47 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.53 Pain Relevance 0.19
Of the two catalytic subunits of IKK (IKKalpha and IKKbeta), low concentrations of NAC and mito-Q activated IKKalpha activity, thereby inhibiting the downstream NF-kappaB and ICAM-1 induction by TNF-alpha.
TNF-alpha Positive_regulation (induction) of ICAM-1
2) Confidence 0.32 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.57 Pain Relevance 0.21
In conclusion, sodium salicylate effectively inhibited TNF-alpha-induced upregulation of NF-kappaB, ICAM-1 expression, in-vitro migration and invasion in human melanoma cells, indicating that non-steroidal anti-inflammatory drugs may be a useful therapeutic approach to oppose inflammation-induced melanoma invasion and metastasis in vivo.
TNF-alpha Positive_regulation (upregulation) of ICAM-1 associated with inflammation, cinod, skin cancer and metastasis
3) Confidence 0.20 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.90 Pain Relevance 0.14
First, the synergistic induction of ICAM-1 by TNF-?
TNF Positive_regulation (induction) of ICAM-1
4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905395 Disease Relevance 0.48 Pain Relevance 0

General Comments

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