INT133050

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.91
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TNF, ICAM1) plasma membrane (TNF, ICAM1) signal transduction (TNF)
extracellular region (TNF) cell adhesion (ICAM1) intracellular (TNF)
Anatomy Link Frequency
endothelial cells 2
TNF (Homo sapiens)
ICAM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 18 97.68 Very High Very High Very High
Inflammation 35 96.72 Very High Very High Very High
rheumatoid arthritis 121 82.56 Quite High
antagonist 1 75.92 Quite High
Infliximab 5 72.00 Quite High
Etanercept 1 68.48 Quite High
Pain 2 59.20 Quite High
cINOD 2 56.48 Quite High
Arthritis 10 46.48 Quite Low
methotrexate 1 45.28 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 34 96.72 Very High Very High Very High
Skin Cancer 7 95.52 Very High Very High Very High
Injury 1 90.12 High High
Rheumatoid Arthritis 121 82.56 Quite High
Adhesions 30 75.00 Quite High
Stress 3 75.00 Quite High
Pain 2 59.20 Quite High
Necrosis 3 53.64 Quite High
Cancer 3 53.28 Quite High
Apoptosis 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF-alpha-stimulated ICAM-1 expression in HBL cells was also downregulated by sodium salicylate, although in a manner inversely related to the concentration of this agent.
TNF-alpha Positive_regulation (stimulated) of Gene_expression (expression) of ICAM-1
1) Confidence 0.67 Published 2006 Journal Melanoma Res. Section Abstract Doc Link 16432451 Disease Relevance 0.77 Pain Relevance 0.11
High concentrations of NAC and mito-Q instead caused glutathionylation of IKKalpha, thereby inhibiting its activity that in turn enhanced the downstream NF-kappaB activation and ICAM-1 expression by TNF-alpha.
TNF-alpha Positive_regulation (enhanced) of Gene_expression (expression) of ICAM-1
2) Confidence 0.47 Published 2007 Journal J. Immunol. Section Abstract Doc Link 17237434 Disease Relevance 0.58 Pain Relevance 0.21
In addition, IL-1 and TNF upregulate the expression of ICAM-1, VCAM-1 and E-selectin on endothelial cells, stimulating leukocyte migration into the joint [76,104].
TNF Positive_regulation (upregulate) of Gene_expression (expression) of ICAM in endothelial cells
3) Confidence 0.07 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.56 Pain Relevance 0.62

General Comments

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