INT133080

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 5.64
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (GATA3) anatomical structure formation involved in morphogenesis (GATA3) DNA binding (GATA3)
signal transduction (GATA3) nucleolus (GATA3) nucleus (GATA3)
Anatomy Link Frequency
T cells 4
lung 2
blood 1
Th2 cell 1
red blood cells 1
GATA3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 1 100.00 Very High Very High Very High
cytokine 387 99.66 Very High Very High Very High
Inflammation 447 99.12 Very High Very High Very High
opioid receptor 9 98.76 Very High Very High Very High
Cannabinoid 8 91.48 High High
agonist 90 87.60 High High
Migraine 61 87.04 High High
antagonist 105 85.84 High High
mu opioid receptor 1 81.08 Quite High
tolerance 3 79.52 Quite High
Disease Link Frequency Relevance Heat
Eosinophilia 63 99.46 Very High Very High Very High
Pneumonia 24 99.12 Very High Very High Very High
Cancer 187 98.36 Very High Very High Very High
Asthma 963 96.64 Very High Very High Very High
INFLAMMATION 474 93.72 High High
Targeted Disruption 60 92.64 High High
Skin Cancer 19 92.52 High High
Anaerobic Bacterial Infections 3 91.68 High High
Malaria 64 87.60 High High
Headache 48 87.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, STAT6 induces expression of the transcription factor GATA3, which also contributes to mu-opioid receptor gene transcription.
Gene_expression (expression) of GATA3 associated with opioid receptor
1) Confidence 0.61 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16434616 Disease Relevance 0 Pain Relevance 0.95
Upregulated ESR1, GATA3, ERBB4, TFF1 and TFF3 gene expression was associated with ER+ ERBB2-amplified tumors.
Gene_expression (expression) of GATA3 associated with cancer
2) Confidence 0.56 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.95 Pain Relevance 0
The transcription factor T-bet controls development of Th1, while GATA-3 directs the Th2 lineage [29].
Gene_expression (directs) of GATA-3
3) Confidence 0.54 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.27 Pain Relevance 0.04
GATA3, ESR1, TFF1, TFF3 and ERBB4 were upregulated, whereas IGF2R, GATA6, EGFR and TGFA were downregulated in ER+ ERBB2-amplified tumors.
Gene_expression (upregulated) of GATA3 associated with cancer
4) Confidence 0.48 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 0.81 Pain Relevance 0
Six family members of have been identified in vertebrates to be part of the GATA family and have been subdivided in two groups: GATA-1, GATA-2, and GATA-3, which are expressed in the hematopoetic system [19].
Gene_expression (expressed) of GATA-3
5) Confidence 0.46 Published 2008 Journal The Open Neurology Journal Section Body Doc Link PMC2577932 Disease Relevance 0.56 Pain Relevance 0.51
, IL-4, IL-17 cytokines by flow cytometry and expression of Tbet, GATA3, RORC, and FOXP3 transcripts by quantitative real-time PCR (qt-RT-PCR).
Gene_expression (expression) of GATA3 associated with cytokine
6) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.05
As analyzed by pre-amplification boosted single-cell real-time PCR, human CD4+IL-9+ T cells expressed GATA3 and RORC, but not IL-10, IL-13, IFN?
Neg (not) Gene_expression (expressed) of GATA3 in T cells
7) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806834 Disease Relevance 0.14 Pain Relevance 0.10
In our analysis the bC rates had a statistical significant difference when total HDR-BT doses administered were < 20 Gy (79.8%) and ?
Gene_expression (doses) of HDR-BT
8) Confidence 0.39 Published 2008 Journal International Journal of Medical Sciences Section Body Doc Link PMC2424177 Disease Relevance 0.05 Pain Relevance 0
The commitment of mouse and human CD4+ T cells to such distinct phenotypes is directed through expression of lineage specific transcription factors, e.g., Tbet for Th1, GATA3 for Th2, and ROR?
Gene_expression (expression) of GATA3 in T cells
9) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.07 Pain Relevance 0.08
In-so-far, these CD4+IL-9+ T cells generated from memory CD4+ T cells are different from mouse CD4+IL-9+ T cells generated from naïve CD4+ T cells in the following aspects: 1) human CD4+IL-9+ T cells express GATA3 and RORC; 2) some human CD4+IL-9+ T cells express FOXP3 and; 3) human CD4+IL-9+ T cells do not express IL-10.
Gene_expression (express) of GATA3 in T cells
10) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.11 Pain Relevance 0.11
CD45RO+ T cells for expression of the Tbet, GATA3, and RORC lineage specification transcription factors by pre-amplification boosted single cell qt-RT-PCR.
Gene_expression (expression) of GATA3 in T cells
11) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0 Pain Relevance 0.07
ligands also decrease antigen-induced airway hyperresponsiveness, lung inflammation and eosinophilia, cytokine production, and GATA-3 expression as well as serum levels of antigen-specific IgE in many different animal models of asthma [163,167-170].
Gene_expression (expression) of GATA-3 in lung associated with asthma, inflammation, pneumonia, eosinophilia and cytokine
12) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.78 Pain Relevance 0.34
Interestingly, expression of GATA-3, CCR3, -4, -8, and ST2L, and the generation of blood eosinophilia, is intact in mice doubly deficient in both IL-4 and IL-13 [304].
Gene_expression (expression) of GATA-3 in blood associated with eosinophilia
13) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.28 Pain Relevance 0.11
Functional candidates include genes encoding a platelet-type phosphofructokinase (PFKP) also expressed in red blood cells, an inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (iPFK-2/PFKFB3), the alpha chain of the interleukin-15 receptor (IL15RA), the alpha chain of the interleukin 2 receptor (IL2RA), protein kinase C theta (PRKCQ), the GATA-binding protein 3 (GATA3), and a gene similar to that of the interleukin 9 receptor precursor (LOC439945).
Gene_expression (expressed) of GATA-binding protein 3 in red blood cells associated with kinase c
14) Confidence 0.11 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1829404 Disease Relevance 0.39 Pain Relevance 0.05
synthesis, lung inflammation, eosinophilia, cytokine production (IL-4, IL-5, IL-6 and IL-13), GATA-3 expression and serum levels of antigen-specific IgE and IgG1.
Gene_expression (expression) of GATA-3 in lung associated with inflammation, pneumonia, eosinophilia and cytokine
15) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 0.61 Pain Relevance 0.25
In vitro IL-27 also inhibits Th2 cell differentiation through decreased expression of GATA-3 and subsequent reduction in IL-4 production [284,285].
Gene_expression (expression) of GATA-3 in Th2 cell
16) Confidence 0.09 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.61 Pain Relevance 0.23

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