INT133082

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Context Info
Confidence 0.15
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 4.27
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map2k7) nucleus (Map2k7) response to stress (Map2k7)
cytoplasm (Map2k7)
Anatomy Link Frequency
sciatic nerves 4
Map2k7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 24 98.76 Very High Very High Very High
Neuritis 32 97.64 Very High Very High Very High
Inflammation 10 77.08 Quite High
cytokine 3 63.60 Quite High
Inflammatory response 1 58.96 Quite High
anesthesia 1 55.28 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 32 97.64 Very High Very High Very High
Immunization 16 95.48 Very High Very High Very High
Necrosis 1 84.36 Quite High
Cancer 1 84.00 Quite High
INFLAMMATION 11 77.08 Quite High
Apoptosis 4 60.24 Quite High
Sepsis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, PPF pretreatment attenuated the phosphorylation of mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and IkappaBalpha, as well as the nuclear translocation of NF-kappaB primed by LPS.
Phosphorylation (phosphorylation) of MAPK/ERK
1) Confidence 0.15 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.31 Pain Relevance 0.19
Western blot analysis showed that the expression levels of both phosphorylated JNK1 (p-JNK1, approximately 46 kDa) and phosphorylated JNK2 (p-JNK2, approximately 54 kDa) in the sciatic nerves of rats with EAN increased significantly (p < 0.05) at day 14 post-immunization (PI) and remained at this level at days 24 and 30 PI, with a slight decrease.
Phosphorylation (phosphorylated) of JNK2 in sciatic nerves associated with immunization, sciatic nerve and neuritis
2) Confidence 0.06 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 0.99 Pain Relevance 0.71
Western blot analysis showed that the expression levels of both phosphorylated JNK1 (p-JNK1, approximately 46 kDa) and phosphorylated JNK2 (p-JNK2, approximately 54 kDa) in the sciatic nerves of rats with EAN increased significantly (p < 0.05) at day 14 post-immunization (PI) and remained at this level at days 24 and 30 PI, with a slight decrease.
Phosphorylation (phosphorylated) of JNK2 in sciatic nerves associated with immunization, sciatic nerve and neuritis
3) Confidence 0.06 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 0.99 Pain Relevance 0.71
Western blot analysis showed that the expression levels of both phosphorylated JNK1 (p-JNK1, approximately 46 kDa) and phosphorylated JNK2 (p-JNK2, approximately 54 kDa) in the sciatic nerves of rats with EAN increased significantly (p < 0.05) at day 14 post-immunization (PI) and remained at this level at days 24 and 30 PI, with a slight decrease.
Phosphorylation (phosphorylated) of JNK2 in sciatic nerves associated with immunization, sciatic nerve and neuritis
4) Confidence 0.06 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 0.99 Pain Relevance 0.72
Western blot analysis showed that the expression levels of both phosphorylated JNK1 (p-JNK1, approximately 46 kDa) and phosphorylated JNK2 (p-JNK2, approximately 54 kDa) in the sciatic nerves of rats with EAN increased significantly (p < 0.05) at day 14 post-immunization (PI) and remained at this level at days 24 and 30 PI, with a slight decrease.
Phosphorylation (phosphorylated) of JNK2 in sciatic nerves associated with immunization, sciatic nerve and neuritis
5) Confidence 0.06 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 0.99 Pain Relevance 0.72

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