INT133085

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 6.13
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8ip1) signal transduction (Mapk8ip1) mitochondrion (Mapk8ip1)
vesicle-mediated transport (Mapk8ip1) endoplasmic reticulum (Mapk8ip1) nucleus (Mapk8ip1)
Anatomy Link Frequency
sciatic nerves 3
joint 1
frontal cortex 1
Mapk8ip1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 3 99.24 Very High Very High Very High
Neuritis 24 98.36 Very High Very High Very High
Pain management 22 97.94 Very High Very High Very High
Sciatic nerve 18 96.56 Very High Very High Very High
fluoxetine 2 94.04 High High
depression 4 88.08 High High
Osteoarthritis 12 81.12 Quite High
Pain 36 79.52 Quite High
Inflammation 18 71.68 Quite High
ischemia 21 70.40 Quite High
Disease Link Frequency Relevance Heat
Dementia 4 99.76 Very High Very High Very High
Stress 8 99.70 Very High Very High Very High
Experimental Autoimmune Neuritis 24 98.36 Very High Very High Very High
Urological Neuroanatomy 3 98.08 Very High Very High Very High
Frailty 24 97.96 Very High Very High Very High
Pain 56 97.72 Very High Very High Very High
Disease 6 93.76 High High
Immunization 12 93.28 High High
Paresis 2 92.92 High High
Stroke 2 92.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, the JRP was modeled after published literature in pain management,[13,16,21,23,25] complication prevention,[23,26] and cost containment after TKA.[25] Furthermore, the JRP was refined after visits to three "Centers for Excellence" in joint replacement throughout the country.
Gene_expression (refined) of JRP in joint associated with frailty and pain management
1) Confidence 0.66 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2596133 Disease Relevance 0.82 Pain Relevance 0.24
The primary reasons patients were not enrolled in the JRP were dementia or insufficient support at home.
Neg (not) Gene_expression (enrolled) of JRP associated with dementia
2) Confidence 0.57 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2596133 Disease Relevance 0.81 Pain Relevance 0.17
Western blot analysis showed that the expression levels of both phosphorylated JNK1 (p-JNK1, approximately 46 kDa) and phosphorylated JNK2 (p-JNK2, approximately 54 kDa) in the sciatic nerves of rats with EAN increased significantly (p < 0.05) at day 14 post-immunization (PI) and remained at this level at days 24 and 30 PI, with a slight decrease.
Gene_expression (expression) of JNK1 in sciatic nerves associated with immunization, sciatic nerve and neuritis
3) Confidence 0.09 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 0.91 Pain Relevance 0.65
Western blot analysis showed that the expression levels of both phosphorylated JNK1 (p-JNK1, approximately 46 kDa) and phosphorylated JNK2 (p-JNK2, approximately 54 kDa) in the sciatic nerves of rats with EAN increased significantly (p < 0.05) at day 14 post-immunization (PI) and remained at this level at days 24 and 30 PI, with a slight decrease.
Gene_expression (expression) of p-JNK1 in sciatic nerves associated with immunization, sciatic nerve and neuritis
4) Confidence 0.08 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 0.97 Pain Relevance 0.71
Western blot analysis showed that the expression levels of both phosphorylated JNK1 (p-JNK1, approximately 46 kDa) and phosphorylated JNK2 (p-JNK2, approximately 54 kDa) in the sciatic nerves of rats with EAN increased significantly (p < 0.05) at day 14 post-immunization (PI) and remained at this level at days 24 and 30 PI, with a slight decrease.
Gene_expression (expression) of p-JNK1 in sciatic nerves associated with immunization, sciatic nerve and neuritis
5) Confidence 0.07 Published 2006 Journal J. Vet. Sci. Section Abstract Doc Link 16434843 Disease Relevance 0.97 Pain Relevance 0.71
Western blot study revealed that rats subjected to prenatal stress had decreased levels of p-JNK1 and p-JNK2 in the hippocampus and p-p38 in the frontal cortex, but the concentrations of p-ERK1 and p-ERK2 were not changed.
Gene_expression (levels) of p-JNK1 in frontal cortex associated with stress, urological neuroanatomy and hippocampus
6) Confidence 0.02 Published 2010 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 20436222 Disease Relevance 1.01 Pain Relevance 0.46
In addition, the expression of pJNK 1/2 was significantly decreased in the ALA 25 mg/kg group compared to the control group as shown with pJNK 1 (2.2±0.2 times vs. 1.7±0.2 times, p<0.05) and pJNK 2 (1.3±0.1 times vs. 1.0±0.1 times, p<0.05) (Fig. 5B) (Table 2).


Gene_expression (expression) of pJNK 1
7) Confidence 0.01 Published 2009 Journal Korean Circulation Journal Section Body Doc Link PMC2771824 Disease Relevance 0.65 Pain Relevance 0.04

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