INT133100

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.48
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tgfb1) enzyme binding (Tgfb1) embryo development (Tgfb1)
cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1)
Anatomy Link Frequency
PSCs 2
plaques 2
Tgfb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 1 91.76 High High
Pain 1 70.80 Quite High
fibrosis 2 66.56 Quite High
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 2 95.32 Very High Very High Very High
Injury 2 95.12 Very High Very High Very High
Disease 9 94.64 High High
Stress 3 91.24 High High
Fibrosis 4 83.12 Quite High
Reprotox - General 2 1 71.92 Quite High
Pain 1 70.80 Quite High
Primary Sclerosing Cholangitis 3 5.00 Very Low Very Low Very Low
Pancreatitis 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is evidence indicating that these profibrotic factors interact with antifibrotic defense mechanisms, such as decrease of myofibroblast accumulation, elimination of reactive oxygen species by inducible nitric oxide synthase and neutralization of transforming-growth-factor beta1 by decorin, such that some plaques are in dynamic turnover.
Negative_regulation (decrease) of Localization (neutralization) of transforming-growth-factor beta1 in plaques
1) Confidence 0.28 Published 2005 Journal Nature clinical practice. Urology Section Abstract Doc Link 16474811 Disease Relevance 1.41 Pain Relevance 0.15
EGCG also suppressed ethanol-induced p38 mitogen-activated protein (MAP) kinase phosphorylation, alpha-smooth muscle actin production in PSCs and activated transforming growth factor-beta1 secretion into the medium.
Negative_regulation (suppressed) of Localization (secretion) of transforming growth factor-beta1 in PSCs
2) Confidence 0.06 Published 2006 Journal Eur. J. Clin. Invest. Section Body Doc Link 16436093 Disease Relevance 0.08 Pain Relevance 0

General Comments

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