INT133102

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Context Info
Confidence 0.08
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.56
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL1A2) extracellular region (COL1A2) protein binding, bridging (COL1A2)
Anatomy Link Frequency
cartilage 6
fibroblasts 4
animal cells 2
COL1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 22 95.76 Very High Very High Very High
Inflammatory marker 2 94.00 High High
Osteoarthritis 56 92.64 High High
cytokine 8 81.72 Quite High
fibrosis 14 80.96 Quite High
agonist 6 71.00 Quite High
imagery 24 68.24 Quite High
corticosteroid 26 66.24 Quite High
Pain 6 59.56 Quite High
Inflammation 12 32.28 Quite Low
Disease Link Frequency Relevance Heat
Recurrence 3 95.00 High High
INFLAMMATION 13 93.68 High High
Disease 35 92.40 High High
Hypertrophy 2 91.84 High High
Osteoarthritis 33 82.72 Quite High
Retroperitoneal Fibrosis 4 80.96 Quite High
Knee Osteoarthritis 36 78.64 Quite High
Cholangitis 2 75.28 Quite High
Pancreatitis 131 74.24 Quite High
Injury 9 73.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aforementioned findings were consistent with the real-time PCR results, which showed the corresponding upregulation of SOX-9, aggrecan and type II collagen gene expression but downregulation of type I collagen expression by MPCs cultured in the presence of PPS.
Negative_regulation (downregulation) of Gene_expression (expression) of type I collagen
1) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875662 Disease Relevance 0.09 Pain Relevance 0
On one side, IL-10 has proanabolic effects, such as promotion of proteoglycan synthesis by human chondrocytes "in vitro" [17], prevention of cartilage destruction by reducing IL-1 and TNF-alpha mRNA expression in articular chondrocytes [17]; on the other side, IL-10 may also exert procatabolic effects as in human fibroblasts it down-regulates type I collagen mRNA expression and enhances collagenase and stromelysin gene expression [18].
Negative_regulation (regulates) of Gene_expression (expression) of type I collagen mRNA in cartilage
2) Confidence 0.06 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2268688 Disease Relevance 0.46 Pain Relevance 0.21
The few studies performed on IVD cells have shown that IL-1 treatment also causes a decrease in proteoglycan and collagen II production in animal cells [24,26-28].
Negative_regulation (decrease) of Gene_expression (production) of collagen II in animal cells
3) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.06 Pain Relevance 0.04
Immunohistochemical findings on day 7 and 28 showed that the expression of type I collagen, type IV collagen, laminin, and vimentin were strongly positive in the transplanted gelatin hydrogels of the precursor/gelatin group while they were faint in the gelatin and fibroblast/gelatin groups.
Negative_regulation (positive) of Gene_expression (expression) of type I collagen in fibroblast
4) Confidence 0.04 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2566587 Disease Relevance 0 Pain Relevance 0
Significant changes were found in the morphology of the cartilage including proteoglycan loss along with decreased BMP-2 and type II procollagen mRNA staining.
Negative_regulation (loss) of Gene_expression (staining) of type II procollagen mRNA in cartilage
5) Confidence 0.03 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18924142 Disease Relevance 0.45 Pain Relevance 0.27
Significant changes were found in the morphology of the cartilage including proteoglycan loss along with decreased BMP-2 and type II procollagen mRNA staining.
Negative_regulation (decreased) of Gene_expression (staining) of type II procollagen mRNA in cartilage
6) Confidence 0.03 Published 2009 Journal J. Orthop. Res. Section Abstract Doc Link 18924142 Disease Relevance 0.45 Pain Relevance 0.27
In vitro lab work has demonstrated that MMF has direct antifibrotic properties by inhibiting type I collagen production, altering the contractile and migratory functions of fibroblasts, and enhancing the production of matrix metalloproteinase (interstitial collagenase) [29].
Negative_regulation (inhibiting) of Gene_expression (production) of type I collagen in fibroblasts associated with metalloproteinase
7) Confidence 0.01 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 0.99 Pain Relevance 0.23
Furthermore, EGCG inhibited ethanol-induced type-I procollagen production and collagen secretion.
Negative_regulation (inhibited) of Gene_expression (production) of procollagen
8) Confidence 0.00 Published 2006 Journal Eur. J. Clin. Invest. Section Body Doc Link 16436093 Disease Relevance 0.07 Pain Relevance 0

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