INT133112

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 11.99
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Baat) peroxisome (Baat) transferase activity, transferring acyl groups (Baat)
molecular_function (Baat) lipid metabolic process (Baat)
Anatomy Link Frequency
BAT 3
body 2
spinal 1
Baat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 2 99.28 Very High Very High Very High
agonist 2 98.64 Very High Very High Very High
Enkephalin 2 97.16 Very High Very High Very High
Central nervous system 6 95.52 Very High Very High Very High
Raphe magnus 2 95.32 Very High Very High Very High
Neurotransmitter 6 87.92 High High
Catecholamine 6 85.44 High High
Raphe 10 75.00 Quite High
Intracerebroventricular 2 70.60 Quite High
depression 12 54.24 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 408 100.00 Very High Very High Very High
Obesity 316 100.00 Very High Very High Very High
Body Weight 42 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 6 96.88 Very High Very High Very High
Apnoea 84 93.64 High High
Fever 6 90.40 High High
Sleep Disorders 30 89.04 High High
Syndrome 18 88.32 High High
Weight Loss 36 86.84 High High
Targeted Disruption 6 84.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test whether medullary OFF cells modulate BAT activity, the mu-opiate receptor agonist (d-Ala2, N-Me-Phe4, Gly-ol5)-enkephalin (DAMGO) was microinjected into the raphe magnus, a manipulation that selectively activates OFF cells.
Spec (whether) Regulation (modulate) of BAT in BAT associated with raphe magnus, obesity, agonist, enkephalin and opiate
1) Confidence 0.61 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16436606 Disease Relevance 1.01 Pain Relevance 0.46
This adaptation may affect the BAT activity.
Spec (may) Regulation (affect) of BAT in BAT associated with obesity
2) Confidence 0.24 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2515839 Disease Relevance 1.14 Pain Relevance 0.09
Noxious stimulation suppressed BAT activation, suggesting that cells inhibited by noxious stimulation facilitate spinal circuits controlling BAT.
Regulation (controlling) of BAT in spinal associated with obesity
3) Confidence 0.23 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16436606 Disease Relevance 1.02 Pain Relevance 0.47
Our initial experiences suggest that future research concentrate on species differences and on the effects of IIH duration on BAT.
Regulation (concentrate) of BAT associated with hypoxia and obesity
4) Confidence 0.18 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2515839 Disease Relevance 1.89 Pain Relevance 0.10
The metabolism and heat production in BAT are primarily controlled by sympathetic impulses [20] and, during nonshivering thermogenesis, more than a half of all the oxygen captured is consumed by BAT [18].
Regulation (controlled) of BAT in BAT associated with obesity
5) Confidence 0.18 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2515839 Disease Relevance 0.99 Pain Relevance 0.08
We recognized the need of additional studies in different species with larger number of animals and with longer expositions in order to confirm the effect of isocapnic intermittent hypoxia on body weight and BAT.


Regulation (effect) of BAT in body associated with body weight, hypoxia and obesity
6) Confidence 0.11 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2515839 Disease Relevance 2.16 Pain Relevance 0
Before engaging in the present study, we performed a pilot study to collect evidence of an effect of IH on BAT.
Regulation (effect) of BAT associated with hypoxia and obesity
7) Confidence 0.11 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2515839 Disease Relevance 1.95 Pain Relevance 0
Our preliminary results justify a larger study for a longer time in order to confirm the effect of isocapnic intermittent hypoxia on body weight and BAT.



Regulation (effect) of BAT in body associated with body weight, hypoxia and obesity
8) Confidence 0.11 Published 2008 Journal Lipids Health Dis Section Abstract Doc Link PMC2515839 Disease Relevance 1.82 Pain Relevance 0

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