INT133118

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 25
Total Number 28
Disease Relevance 13.05
Pain Relevance 9.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (FAAH) cytoplasm (FAAH)
Anatomy Link Frequency
plasma 1
liver 1
AT-1 1
Sertoli cells 1
brain 1
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 8 99.84 Very High Very High Very High
headache 9 99.56 Very High Very High Very High
Endocannabinoid 277 99.48 Very High Very High Very High
cytokine 100 99.08 Very High Very High Very High
Pain 45 98.20 Very High Very High Very High
acular 4 97.86 Very High Very High Very High
depression 15 97.68 Very High Very High Very High
rheumatoid arthritis 396 97.36 Very High Very High Very High
cINOD 16 97.22 Very High Very High Very High
Osteoarthritis 356 97.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 16 99.84 Very High Very High Very High
Prostate Cancer 204 99.68 Very High Very High Very High
Pain 48 98.20 Very High Very High Very High
Anxiety Disorder 16 97.96 Very High Very High Very High
Depression 15 97.68 Very High Very High Very High
Rheumatoid Arthritis 396 97.36 Very High Very High Very High
Frailty 360 97.08 Very High Very High Very High
Neurological Disease 3 96.72 Very High Very High Very High
Inflammatory Pain 8 96.00 Very High Very High Very High
Metabolic Disorder 2 95.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
Negative_regulation (inhibitors) of FAAH
1) Confidence 0.59 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 19850474 Disease Relevance 0.26 Pain Relevance 0.13
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
Negative_regulation (inhibitors) of fatty acid amide hydrolase
2) Confidence 0.59 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 19850474 Disease Relevance 0.25 Pain Relevance 0.13
Recently, carbamate, urea and ketone inhibitors of fatty acid amide hydrolase (FAAH) have been described as promising treatments for pain, anxiety, depression and other CNS-related conditions.
Negative_regulation (inhibitors) of FAAH associated with pain, depression and anxiety disorder
3) Confidence 0.59 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 19850474 Disease Relevance 0.29 Pain Relevance 0.15
Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
Negative_regulation (inhibitors) of FAAH
4) Confidence 0.59 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 19850474 Disease Relevance 0.26 Pain Relevance 0.13
Recently, carbamate, urea and ketone inhibitors of fatty acid amide hydrolase (FAAH) have been described as promising treatments for pain, anxiety, depression and other CNS-related conditions.
Negative_regulation (inhibitors) of fatty acid amide hydrolase associated with pain, depression and anxiety disorder
5) Confidence 0.59 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 19850474 Disease Relevance 0.29 Pain Relevance 0.15
Inhibition of FAAH activity has been suggested as a therapeutic approach for the treatment of chronic pain, depression and anxiety, through local activation of the cannabinoid receptor CB1.
Negative_regulation (Inhibition) of FAAH associated with cannabinoid receptor, depression, lasting pain and anxiety disorder
6) Confidence 0.59 Published 2007 Journal J. Neurosci. Methods Section Abstract Doc Link 17083980 Disease Relevance 0.29 Pain Relevance 0.24
Ethanolamides are considered to be potential pharmacodynamic biomarkers to determine target engagement for FAAH inhibition by novel pharmaceutical agents.
Negative_regulation (inhibition) of FAAH
7) Confidence 0.59 Published 2010 Journal J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Section Abstract Doc Link 20462810 Disease Relevance 0.38 Pain Relevance 0.14
Validation and application of an LC-MS/MS method for quantitation of three fatty acid ethanolamides as biomarkers for fatty acid hydrolase inhibition in human plasma.
Negative_regulation (inhibition) of fatty acid hydrolase in plasma
8) Confidence 0.59 Published 2010 Journal J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. Section Title Doc Link 20462810 Disease Relevance 0.36 Pain Relevance 0.13
(which decrease FAAH activity in lymphocytes), progesterone, leptin, the TH2 cytokines IL-4 and IL-10 (which increase FAAH activity and FAAH protein content in lymphocytes), and follicle stimulating hormone (which increases FAAH activity in Sertoli cells) [26], [65], [66].
Negative_regulation (decrease) of FAAH in Sertoli cells associated with cytokine
9) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.63 Pain Relevance 0.13
Those authors concluded that “inhibition of FAAH activity by specific inhibitors may be one therapeutic target for the treatment of prostate cancer” [12].
Negative_regulation (inhibition) of FAAH associated with prostate cancer
10) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.85 Pain Relevance 0.43
These studies revealed phenmedipham 13 and amperozide 14 to be inhibitors of human FAAH, with an IC(50) of 377 nM and 1.34 microM, respectively.
Negative_regulation (inhibitors) of FAAH
11) Confidence 0.51 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 19850474 Disease Relevance 0.26 Pain Relevance 0.13
Collectively these data demonstrate that D-AMC can be successfully used to rapidly and effectively identify novel FAAH inhibitors for potential therapeutic use.
Negative_regulation (inhibitors) of FAAH
12) Confidence 0.51 Published 2007 Journal J. Neurosci. Methods Section Abstract Doc Link 17083980 Disease Relevance 0.17 Pain Relevance 0.18
Inhibitors of FAAH are potentially useful for the treatment of pain, anxiety, depression, and other nervous system disorders.
Negative_regulation (Inhibitors) of FAAH in nervous system associated with pain, neurological disease, depression and anxiety disorder
13) Confidence 0.46 Published 2007 Journal Neuropharmacology Section Abstract Doc Link 17217969 Disease Relevance 0.39 Pain Relevance 0.15
In order to find novel FAAH inhibitors, a focused screen of molecules containing potentially reactive moieties or having in vivo effects that are possibly relevant to the biology of FAAH was conducted.
Negative_regulation (inhibitors) of FAAH
14) Confidence 0.43 Published 2009 Journal Bioorg. Med. Chem. Lett. Section Abstract Doc Link 19850474 Disease Relevance 0.29 Pain Relevance 0.15
Certain FAAs are also able to partially inhibit the action of fatty acid amide hydrolase (FAAH), which controls the breakdown of endocannabinoids.
Negative_regulation (inhibit) of FAAH associated with endocannabinoid
15) Confidence 0.43 Published 2008 Journal Planta Med. Section Abstract Doc Link 18275004 Disease Relevance 0.23 Pain Relevance 0.61
Certain FAAs are also able to partially inhibit the action of fatty acid amide hydrolase (FAAH), which controls the breakdown of endocannabinoids.
Negative_regulation (inhibit) of fatty acid amide hydrolase associated with endocannabinoid
16) Confidence 0.43 Published 2008 Journal Planta Med. Section Abstract Doc Link 18275004 Disease Relevance 0.23 Pain Relevance 0.61
METHODS: The authors measured whole blood levels of anandamide in 12 patients after induction of general anesthesia with etomidate (an agent shown to have no effect on anandamide levels) and maintenance of anesthesia with the volatile agent sevoflurane as well as in 12 patients undergoing total intravenous anesthesia with propofol, a known inhibitor of fatty acid amide hydrolase in the mouse brain.
Negative_regulation (inhibitor) of acid amide hydrolase in brain
17) Confidence 0.43 Published 2006 Journal Anesthesiology Section Body Doc Link 16436846 Disease Relevance 0 Pain Relevance 0
Several NSAIDs, including ibuprofen, ketorolac, indometacin, and niflumic acid, which act via the inhibition of cyclooxygenase (COX), have been shown to inhibit FAAH [26,27].
Negative_regulation (inhibit) of FAAH associated with acular and cinod
18) Confidence 0.42 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0.94 Pain Relevance 1.21
FAAH inhibitors, which do not produce the sort of central behavioural effects associated with cannabinoids like ?
Negative_regulation (inhibitors) of FAAH associated with cannabinoid
19) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.90 Pain Relevance 0.43
In our hands, the hydrolysis of 2-AG by intact PC-3 cells is only marginally inhibited by the selective FAAH inhibitor URB597, and in the case of R3327 AT-1 cells, no inhibition is seen [47].
Negative_regulation (inhibitor) of FAAH in AT-1
20) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.33 Pain Relevance 0.07

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