INT133144

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Context Info
Confidence 0.24
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 7.88
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtpn) nucleus (Mtpn) cytoplasm (Mtpn)
Anatomy Link Frequency
platelet 4
endothelial cells 1
poly 1
Spinal cord 1
fibroblasts 1
Mtpn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
neuropeptide release 3 100.00 Very High Very High Very High
Angina 2 99.84 Very High Very High Very High
cytokine 95 99.80 Very High Very High Very High
Spinal cord 21 99.34 Very High Very High Very High
Calcitonin gene-related peptide 130 99.00 Very High Very High Very High
adenocard 10 97.52 Very High Very High Very High
chemokine 60 97.12 Very High Very High Very High
Cannabinoid 2 96.96 Very High Very High Very High
Nerve growth factor 161 96.88 Very High Very High Very High
Inflammation 128 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 394 99.88 Very High Very High Very High
Cv General 3 Under Development 3 99.84 Very High Very High Very High
Adhesions 22 99.10 Very High Very High Very High
Death 11 98.80 Very High Very High Very High
Hypoxia 15 98.16 Very High Very High Very High
Wound Healing 108 97.72 Very High Very High Very High
Necrosis 25 97.16 Very High Very High Very High
INFLAMMATION 135 96.80 Very High Very High Very High
Cardiovascular Disease 14 96.56 Very High Very High Very High
Mucositis 3 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeting vascular endothelial growth factor in angina therapy.
Localization (Targeting) of growth factor associated with angina
1) Confidence 0.24 Published 2006 Journal Expert Opin. Ther. Targets Section Title Doc Link 16441224 Disease Relevance 0.10 Pain Relevance 0.10
Since perforating the peritoneum affected the same somatic segments used by Stener-Victorin et. al. [17], we presume that bilateral and left side surgical procedures resulted in an increase of neural growth factor concentrations at the ovarian level, which in turn induced the increase in testosterone secretion.
Localization (secretion) of neural growth factor in neural
2) Confidence 0.09 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1448196 Disease Relevance 0 Pain Relevance 0.09
These include neuromedin U, heptocyte growth factor, steroid-5-alpha-reductase (SRD5A2), SLC30A3, PC4, SFRS1 interacting protein 1 (PSIP1), PER2, ZHX2 and ENC1.
Localization (heptocyte) of growth factor
3) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2949723 Disease Relevance 0.24 Pain Relevance 0.15
, proliferin, platelet-derived growth factor, IL-8, TGF-?
Localization (platelet) of growth factor in platelet
4) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.07 Pain Relevance 0
Insulin growth factor (IGF)-I-stimulated PRL release (but not IGF-I-inhibition of GH release) could also be blunted by anti-VIP antibody (360).
Localization (release) of growth factor
5) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.08 Pain Relevance 0.26
Growth factor secretion by LLL and its apparent regenerative activities have stimulated studies in radiation-induced mucositis.
Localization (secretion) of Growth factor associated with mucositis
6) Confidence 0.03 Published 2010 Journal J Transl Med Section Body Doc Link PMC2830167 Disease Relevance 0.89 Pain Relevance 0.11
To test whether growth factor-mediated enhancement of neuropeptide release might be generalizable to other TRPV1 secretagogues, we evaluated the dual cannabinoid-vanilloid agonists AEA and ACEA.
Localization (release) of growth factor associated with cannabinoid, agonist and neuropeptide release
7) Confidence 0.03 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC548274 Disease Relevance 0.25 Pain Relevance 1.22
Spinal cord data suggest an increase in the release of vascular endothelial growth factor (VEGF) as a result of impaired perfusion and hypoxia signalling [31].
Localization (release) of growth factor in Spinal cord associated with hypoxia and spinal cord
8) Confidence 0.03 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1933540 Disease Relevance 0.76 Pain Relevance 0.08
Detailed analysis of the secreted growth factor and cytokine profile, including, but not limited to, platelet-derived growth factor-BB, vascular endothelial growth factor, angiogenin, TIMP-1, and TIMP-2 were previously reported.8
Localization (secreted) of growth factor in platelet associated with cytokine
9) Confidence 0.03 Published 2008 Journal Eplasty Section Body Doc Link PMC2323202 Disease Relevance 0.53 Pain Relevance 0.31
In the early days after injury, the growth factor is released from platelets and endothelial cells.
Localization (released) of growth factor in endothelial cells associated with injury
10) Confidence 0.02 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727777 Disease Relevance 0.90 Pain Relevance 0.03
This approach offers a technology to accurately control growth factor release to promote soft tissue engineering in vivo.



Localization (release) of growth factor
11) Confidence 0.02 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2248711 Disease Relevance 0.06 Pain Relevance 0.13
Poly(L-lactic acid) (PLLA) and poly(lactide-co-glycolide) (PLGA) are biodegradable polymers with great potential for use in delivery of polypeptides and proteins, because, in addition to their biocompatibility, the release rate of polypeptides can be controlled by adjusting the factor loading, polymer molecular weight, lactide/glycolide ratio in the copolymer, and formulation methods.[21], [22] Recently, our group has developed a novel PLLA (poly-L-lactic acid) porous scaffold with the characteristic of PLLA nanofibrous pore walls (instead of the solid pore walls), which increases the scaffold porosity to 98%, favoring diffusion of nutrients and oxygen.[23] In addition, based on the finding that polymers with high molecular weight (HMW) degrade more slowly than those with low molecular weight (LMW), the in vivo release of growth factor embedded in microspheres is controlled by molecular weight,[22] which is different from the traditional simple coating method in which the release rate of growth factors depends on physico-chemical interactions between the adsorbed growth factors and scaffold surfaces.
Localization (release) of growth factor in poly
12) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.11 Pain Relevance 0
Compared to single application of growth factor protein, delivery of gene to the target tissue has the advantage of sustained and prolonged release of growth factor.
Localization (release) of growth factor
13) Confidence 0.01 Published 2010 Journal J Orthop Surg Res Section Body Doc Link PMC2931497 Disease Relevance 0 Pain Relevance 0
Studies should also be done to control the release of growth factor.
Localization (release) of growth factor
14) Confidence 0.01 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2879239 Disease Relevance 0.08 Pain Relevance 0
In the early days after injury, the growth factor is released from platelets and endothelial cells.
Localization (released) of growth factor in platelets associated with injury
15) Confidence 0.01 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727777 Disease Relevance 0.90 Pain Relevance 0.03
It is discovered in another study that microcurrent stimulates dermal fibroblasts and U937 cells to secrete transforming growth factor-?
Localization (secrete) of growth factor in fibroblasts
16) Confidence 0.01 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2792735 Disease Relevance 1.08 Pain Relevance 0.10
Electrical fields stimulate secretion of growth factor 28.
Localization (secretion) of growth factor
17) Confidence 0.01 Published 2010 Journal International Journal of Medical Sciences Section Body Doc Link PMC2792735 Disease Relevance 0.92 Pain Relevance 0.09
Chitosan enhances platelet adhesion and aggregation [165,173] and increases the release of the platelet derived growth factor-AB (PDGF-AB) and the transforming growth factor-?
Localization (release) of growth factor-AB in platelet associated with adhesions
18) Confidence 0.01 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2885077 Disease Relevance 0.91 Pain Relevance 0.08

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