INT133156

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 77
Total Number 79
Disease Relevance 45.92
Pain Relevance 13.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cd40) extracellular region (Cd40) plasma membrane (Cd40)
enzyme binding (Cd40)
Anatomy Link Frequency
microglia 8
T cells 8
B cell 6
monocytes 2
astrocyte 2
Cd40 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 281 100.00 Very High Very High Very High
rheumatoid arthritis 215 100.00 Very High Very High Very High
Central nervous system 360 99.92 Very High Very High Very High
Cannabinoid 88 99.60 Very High Very High Very High
Inflammation 892 99.44 Very High Very High Very High
cytokine 851 99.28 Very High Very High Very High
Hippocampus 43 99.24 Very High Very High Very High
agonist 235 99.22 Very High Very High Very High
Nerve growth factor 32 98.76 Very High Very High Very High
imagery 30 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 216 100.00 Very High Very High Very High
Immunization 138 100.00 Very High Very High Very High
Arthritis 128 100.00 Very High Very High Very High
Infarction 20 100.00 Very High Very High Very High
Disease 991 99.96 Very High Very High Very High
Encephalitis 62 99.92 Very High Very High Very High
Demyelinating Disease 140 99.90 Very High Very High Very High
Alzheimer's Dementia 538 99.84 Very High Very High Very High
Multiple Sclerosis 304 99.84 Very High Very High Very High
Autoimmune Disease 219 99.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Suppression of the CD40-CD154 interaction has been shown to actually induce generation of T regulatory (Treg) cells [8].
CD40 Binding (interaction) of
1) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.90 Pain Relevance 0.37
This therapy is highly effective in mouse models [4,18], although the overall benefit of interruption of CD40-CD154 association is reduced when Abs is administrated after disease establishment.
CD40 Binding (association) of associated with disease
2) Confidence 0.48 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.82 Pain Relevance 0.22
Having established that CD40 ligation attenuates innate (phagocytic) activation of microglia challenged with A?
CD40 Binding (ligation) of in microglia
3) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.37 Pain Relevance 0.35
, we then examined the role of CD40 ligation in APC function of A?
CD40 Spec (examined) Binding (ligation) of
4) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.35 Pain Relevance 0.33
challenge, CD40 ligation is able to shift activated microglia from innate to adaptive activation.
CD40 Binding (ligation) of in microglia
5) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.51 Pain Relevance 0.29
-amyloid in the context of CD40 ligation
CD40 Binding (ligation) of associated with alzheimer's dementia
6) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 1.14 Pain Relevance 0.24
Interestingly, CD40 ligation promoted "loading" of A?
CD40 Binding (ligation) of
7) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.27 Pain Relevance 0.33
secretion, co-stimulation provided in the form of CD40 ligation (either via CD40L or an agonistic CD40 antibody) results in TNF-?
CD40 Binding (ligation) of
8) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.97 Pain Relevance 0.21
In the EAE model, murine microglia seem to largely support an adaptive activation of encephalitogenic T cells in the presence of the CD40-CD40 ligand interaction.
CD40-CD40 Binding (interaction) of in microglia associated with multiple sclerosis
9) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 0.56 Pain Relevance 0.28
Adaptive response of activated microglia in demyelinating disease via CD40-CD40 ligand interaction
CD40-CD40 Binding (interaction) of in microglia associated with demyelinating disease
10) Confidence 0.44 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC1298325 Disease Relevance 1.33 Pain Relevance 0.32
peptide challenge in the presence of CD40 ligation.
CD40 Binding (ligation) of
11) Confidence 0.43 Published 2005 Journal J Neuroinflammation Section Abstract Doc Link PMC1352348 Disease Relevance 0.22 Pain Relevance 0.38
Essential to microglial activation is the stimulatory signal from CD40 ligation.
CD40 Binding (ligation) of
12) Confidence 0.42 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2569027 Disease Relevance 1.17 Pain Relevance 0.27
We demonstrated ligation of microglial CD40 synergistically enhanced autocrine activation by A?
CD40 Binding (ligation) of
13) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.75 Pain Relevance 0.38
challenge in the PSAPP mouse model of AD, CD40 ligation is able to shift activated microglia from innate to adaptive activation.
CD40 Binding (ligation) of in microglia associated with disease
14) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.80 Pain Relevance 0.28
For example, experimental autoimmune encephalitis model seems to largely support an adaptive, antigen presenting activation of encephalitogenic T cells in the presence of the CD40-CD40 ligand interaction [45]–[47].
CD40-CD40 Binding (interaction) of in T cells associated with viral meningitis
15) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2366070 Disease Relevance 0.85 Pain Relevance 0.30
Nevertheless, it is well-known that functional ligation by macrophages/monocytes with T cell CD40 ligand is important for their CD40 expression and effector functions such as TNF alpha and nitric oxide production [20].
CD40 Binding (ligation) of in macrophages
16) Confidence 0.39 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.24 Pain Relevance 0.14
Moreover, genetic studies have recently documented an important association between rheumatoid arthritis and CD40 variants, supporting the relevance of CD40 for inflammatory disease development [21].
CD40 Binding (association) of associated with inflammation, rheumatoid arthritis and disease
17) Confidence 0.39 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.30 Pain Relevance 0.18
This finding may seem unexpected, since this surface marker on CD4 + T cells is known to interact with CD40 on antigen-presenting cells, found by us to become strongly up-regulated on monocytes [19].
CD40 Binding (interact) of in monocytes
18) Confidence 0.39 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.24 Pain Relevance 0.07
Treatment with CD40 siRNA remarkably inhibited Th1 recall response, as evidenced by decreased IL-2 (Figure 2C), and IFN-?
CD40 siRNA Binding (Treatment) of
19) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.27 Pain Relevance 0.21
However, unlike our previous experiments in which CD40 knockdown was performed ex vivo on antigen-pulsed DC to induce immune deviation [10], here siRNA to CD40 was systemically administered two days prior to immunization with CII.
CD40 Binding (immunization) of in CII associated with immunization
20) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875641 Disease Relevance 0.28 Pain Relevance 0.05

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