INT133170

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.32
Pain Relevance 1.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12b) extracellular region (Il12b) cytoplasm (Il12b)
Anatomy Link Frequency
macrophages 1
bone marrow 1
Il12b (Mus musculus)
Pain Link Frequency Relevance Heat
Delta-9-tetrahydrocannabinol 9 99.98 Very High Very High Very High
Cannabinoid receptor 4 99.34 Very High Very High Very High
qutenza 2 98.76 Very High Very High Very High
cytokine 347 96.64 Very High Very High Very High
chemokine 27 86.68 High High
Endocannabinoid 1 80.48 Quite High
Cannabinoid 2 74.28 Quite High
agonist 12 59.68 Quite High
antagonist 10 57.96 Quite High
peptic ulcer disease 8 48.64 Quite Low
Disease Link Frequency Relevance Heat
Repression 112 100.00 Very High Very High Very High
Mycobacterial Infection 904 99.88 Very High Very High Very High
Candida Infection 48 99.54 Very High Very High Very High
Infection 368 98.64 Very High Very High Very High
Targeted Disruption 15 91.84 High High
Sprains And Strains 202 73.60 Quite High
Bordatella Infection 1 70.24 Quite High
Cryptococcus Infection 1 70.08 Quite High
Fungal Infection 3 65.44 Quite High
Eczema 22 56.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
mmaA4 TDM was significantly more stimulatory and had reduced capacity to inhibit IL-12p40 responses.


Negative_regulation (inhibit) of IL-12p40
1) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.31 Pain Relevance 0.04
This approach led to the identification of the mmaA4 gene, which encodes a methyl transferase required for introducing the distal oxygen-containing modifications of mycolic acids, as a key locus involved in the repression of IL-12p40.
Negative_regulation (repression) of IL-12p40 associated with repression
2) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2390761 Disease Relevance 0.64 Pain Relevance 0
We believed that additional bacterial components of M. tuberculosis involved in IL-12p40 repression could be revealed by extending our screening approach to saturation.
Negative_regulation (repression) of IL-12p40 associated with mycobacterial infection and repression
3) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.74 Pain Relevance 0.10
As part of the mechanism of M. tuberculosis pathogenesis, our results provide new insights into the link between oxygenated mycolic acids on TDM and the suppression of IL-12p40-mediated immunity contributed by macrophages.
Negative_regulation (suppression) of IL-12p40-mediated in macrophages associated with mycobacterial infection
4) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.61 Pain Relevance 0
IL-12p40 dependent attenuation of virulence of the ?
Negative_regulation (attenuation) of IL-12p40
5) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.31 Pain Relevance 0.04
The attenuation of virulence was reversed in IL-12p40-deficient mice, indicating that this attenuation depended on IL-12p40-mediated immunity.
Negative_regulation (reversed) of IL-12p40-deficient
6) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.60 Pain Relevance 0.04
In addition to our current findings for TDM, the ESAT-6 protein of M. tuberculosis also suppresses IL-12p40 [49],[50].
Negative_regulation (suppresses) of IL-12p40 associated with mycobacterial infection
7) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.66 Pain Relevance 0.12
This experiment revealed that combining the two TDMs led to significant inhibition of the IL-12p40 response stimulated by the mutant TDM alone (Fig. 5A, left).
Negative_regulation (inhibition) of IL-12p40
8) Confidence 0.04 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.30 Pain Relevance 0.21
Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila.
Negative_regulation (suppression) of IL-12p40 in bone marrow associated with qutenza, cannabinoid receptor and delta-9-tetrahydrocannabinol
9) Confidence 0.02 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16443217 Disease Relevance 0.22 Pain Relevance 0.93
M) to the medium during bacterial challenge decreases IL-12p40 and IL-12p35 message levels but increases IL-23 message levels.
Negative_regulation (decreases) of IL-12p40
10) Confidence 0.01 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0 Pain Relevance 0.12
The detection limits of TARC/CCL17, MDC/CCL22, IL-12p40, IFN-?
Negative_regulation (limits) of IL-12p40
11) Confidence 0.01 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2854722 Disease Relevance 0.11 Pain Relevance 0.20
However, systemic infection with intravenously inoculation of C albicans appears unaffected by IL-12p40 deficiency [58].

3.2.

Negative_regulation (deficiency) of IL-12p40 associated with candida infection and infection
12) Confidence 0.01 Published 2011 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2963117 Disease Relevance 0.83 Pain Relevance 0.07

General Comments

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