INT133172

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 98
Total Number 98
Disease Relevance 52.16
Pain Relevance 10.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12b) extracellular region (Il12b) cytoplasm (Il12b)
Anatomy Link Frequency
macrophages 26
dendritic cells 4
T cells 3
bone marrow 2
CD86 2
Il12b (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 218 100.00 Very High Very High Very High
cytokine 2522 99.98 Very High Very High Very High
agonist 99 99.42 Very High Very High Very High
psoriasis 75 98.98 Very High Very High Very High
rheumatoid arthritis 340 98.88 Very High Very High Very High
addiction 7 98.66 Very High Very High Very High
Inflammation 649 98.60 Very High Very High Very High
Arthritis 281 98.24 Very High Very High Very High
Inflammatory mediators 31 97.16 Very High Very High Very High
antagonist 50 96.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Repression 721 100.00 Very High Very High Very High
Infection 3833 99.98 Very High Very High Very High
Mycobacterial Infection 5770 99.78 Very High Very High Very High
Cold Sores 1501 99.76 Very High Very High Very High
Viral Infection 106 99.68 Very High Very High Very High
Sprains And Strains 1518 99.50 Very High Very High Very High
Cancer 799 99.28 Very High Very High Very High
Psoriasis 91 99.04 Very High Very High Very High
Rheumatoid Arthritis 341 98.88 Very High Very High Very High
INFLAMMATION 738 98.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, our data are consistent with recent evidence showing that bioactive IL-23 (p19/p40) was barely detectable in joints of patients with RA [47].
Gene_expression (detectable) of p40 in joints associated with rheumatoid arthritis
1) Confidence 0.75 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991017 Disease Relevance 0.33 Pain Relevance 0.14
The dependence on infectivity is, however, in conflict with results from in vivo production of IL-12p40 and IFN-?
Gene_expression (production) of IL-12p40 associated with addiction
2) Confidence 0.23 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.21 Pain Relevance 0.12
In the initial response of spleen cells in mice injected in vivo with extracts of toxoplasma gondii or with lipopolysaccharide (LPS), the cellular source was found to be dendritic cells, but cultured macrophages have by themselves also been shown to produce IL-12p40 upon HSV-2 infection [238,239].
Gene_expression (produce) of IL-12p40 in dendritic cells associated with cold sores and infection
3) Confidence 0.23 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.26 Pain Relevance 0.03
In these and other studies, the producers of IL-12p40 during viral infection seem to be inflammatory cells, including macrophages, and not the infected stromal cells [365,367].
Gene_expression (producers) of IL-12p40 in stromal cells associated with inflammation and viral infection
4) Confidence 0.23 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.30 Pain Relevance 0.12
B in HSV-infected cells, and the production of IL-12p40 was found to be repressed by an inhibitor of NF-?
Gene_expression (production) of IL-12p40 associated with cold sores
5) Confidence 0.20 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.94 Pain Relevance 0.07
The p35 subunit has homologies to IL-6, and p40 is homologous to the extracellular domain of the haematopoietin receptor family, particularly the IL-6R?
Gene_expression (is) of p40
6) Confidence 0.20 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.10 Pain Relevance 0.08
In human macrophages, TNF has been shown to inhibit IL-12p40 production, but not p35 production, by a mechanism not involving NF-?
Gene_expression (production) of IL-12p40 in macrophages
7) Confidence 0.20 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.77 Pain Relevance 0.06
IL-23 is composed of the IL-12p40 and a p19 subunit and likewise binds to a receptor with one of the IL-12 receptor subunits (IL-12R?
Gene_expression (subunit) of IL-12p40
8) Confidence 0.20 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.43 Pain Relevance 0.22
the production of IL-12 p70 in astrocytes [34].
Gene_expression (production) of IL-12 p70 in astrocytes
9) Confidence 0.18 Published 2008 Journal PPAR Research Section Body Doc Link PMC2441778 Disease Relevance 0.53 Pain Relevance 0.28
Additional studies are being performed which address whether PTU treatment of patients with plaque psoriasis leads to reduced in situ IL-12 expression, alters production of the IL-35 or IL-40 components of the IL-70 heterodimer, as well as exerts an effect by enhancing apoptosis in the proliferated keratinocytes that make up the psoriatic plaque which would result in clinical improvement.


Gene_expression (production) of IL-40 in keratinocytes associated with psoriasis and apoptosis
10) Confidence 0.09 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.53 Pain Relevance 0.21
IL-12 p70 was not detectable in BALF from adult mice at any timepoint, irrespective of treatment (data not shown).
Neg (not) Gene_expression (detectable) of IL-12 p70
11) Confidence 0.09 Published 2005 Journal Respir Res Section Body Doc Link PMC1325022 Disease Relevance 0.89 Pain Relevance 0.05
Collectively, these observations invite an alternative interpretation of the mechanism of action of IL-12p40 in neuroinflammation; namely, that its role is in the production of IL-23 and reinforcement of the Th17 effector cell population, rather than (or in addition to) the production of IL-12p70 and promotion of Th1 differentiation.
Gene_expression (production) of IL-12p70
12) Confidence 0.08 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442630 Disease Relevance 0.40 Pain Relevance 0.09
This disparity between a protective response when IL-12 is produced at the time of infection and a lack of enhanced immunity when IL-12 is constitutively expressed, underscores the importance of temporal and spatial regulation of IL-12p40 expression during infection.
Gene_expression (expression) of IL-12p40 associated with infection
13) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.84 Pain Relevance 0
In addition to the modification of mycolic acids in TDM, the modification of M. tuberculosis lipomannan (LM) by attachment of a large arabinan to generate lipoarabinomannan (LAM) also may represent a strategy designed to block the ability of a mycobacterial glycolipid to activate IL-12p40 production [25],[47].
Gene_expression (production) of IL-12p40 associated with mycobacterial infection
14) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 1.01 Pain Relevance 0.27
To identify the mechanisms and effector molecules responsible for this, we screened a transposon library of M. tuberculosis mutants using a macrophage cell line expressing a reporter gene for monitoring IL-12p40 expression.
Gene_expression (expression) of IL-12p40 in macrophage associated with mycobacterial infection
15) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.57 Pain Relevance 0.07
mmaA4 mutant TDMs, we examined the impact of each on IL-12p40 production in response to E. coli lipopolysaccharide (LPS).
Gene_expression (production) of IL-12p40
16) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.38 Pain Relevance 0.14
Given previous findings on the ability of IL-12 to enhance protective immunity and extend survival in mice and humans infected with M. tuberculosis [12],[23],[24], and the discovery that M. tuberculosis represses IL-12p40 production, we hypothesized that M. tuberculosis actively dampens the production of IL-12p40 cytokine in infected macrophages.
Gene_expression (production) of IL-12p40 in macrophages associated with mycobacterial infection and cytokine
17) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.70 Pain Relevance 0.11
IL-12p40 production was detected at 22 hr in conditioned media from macrophages that were treated with ?
Gene_expression (production) of IL-12p40 in macrophages
18) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.14 Pain Relevance 0.08
Both the GFP expression of the reporter macrophage cell line and supernatant levels of IL-12p40 in primary macrophage cultures confirmed that the avirulent M. smegmatis strain was a robust inducer of IL-12p40 production.
Gene_expression (production) of IL-12p40 in macrophage associated with sprains and strains
19) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.70 Pain Relevance 0.04
To explore the hypothesis that the low levels of IL-12p40 produced by macrophages infected with M. tuberculosis resulted from active inhibition of IL-12p40 transcription, we used the reporter cell line to screen for mutant bacilli that had lost this function.
Gene_expression (produced) of IL-12p40 in macrophages associated with mycobacterial infection
20) Confidence 0.07 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.73 Pain Relevance 0.05

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