INT133174

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Context Info
Confidence 0.15
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 31
Disease Relevance 13.04
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il12b) extracellular region (Il12b) cytoplasm (Il12b)
Anatomy Link Frequency
macrophages 16
CD86 4
plasma 2
bone marrow 2
NK cell 2
Il12b (Mus musculus)
Pain Link Frequency Relevance Heat
chemokine 33 100.00 Very High Very High Very High
addiction 3 99.08 Very High Very High Very High
psoriasis 23 98.98 Very High Very High Very High
Inflammatory mediators 8 97.16 Very High Very High Very High
antagonist 5 96.92 Very High Very High Very High
Delta-9-tetrahydrocannabinol 9 95.84 Very High Very High Very High
cytokine 743 94.40 High High
cva 3 94.08 High High
Endocannabinoid 1 89.28 High High
Inflammation 102 86.64 High High
Disease Link Frequency Relevance Heat
Repression 269 100.00 Very High Very High Very High
Sprains And Strains 485 99.72 Very High Very High Very High
Mycobacterial Infection 2148 99.62 Very High Very High Very High
Cancer 560 99.46 Very High Very High Very High
Psoriasis 34 98.98 Very High Very High Very High
Infection 1377 98.96 Very High Very High Very High
Colitis 69 98.24 Very High Very High Very High
Apoptosis 35 97.28 Very High Very High Very High
INFLAMMATION 120 96.76 Very High Very High Very High
Paralysis 2 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The p35 subunit has homologies to IL-6, and p40 is homologous to the extracellular domain of the haematopoietin receptor family, particularly the IL-6R?
Positive_regulation (homologous) of Gene_expression (is) of p40
1) Confidence 0.15 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.10 Pain Relevance 0.08
The dependence on infectivity is, however, in conflict with results from in vivo production of IL-12p40 and IFN-?
Positive_regulation (results) of Gene_expression (production) of IL-12p40 associated with addiction
2) Confidence 0.15 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 1.22 Pain Relevance 0.12
IL-23 is composed of the IL-12p40 and a p19 subunit and likewise binds to a receptor with one of the IL-12 receptor subunits (IL-12R?
Positive_regulation (composed) of Gene_expression (subunit) of IL-12p40
3) Confidence 0.15 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.43 Pain Relevance 0.23
Additional studies are being performed which address whether PTU treatment of patients with plaque psoriasis leads to reduced in situ IL-12 expression, alters production of the IL-35 or IL-40 components of the IL-70 heterodimer, as well as exerts an effect by enhancing apoptosis in the proliferated keratinocytes that make up the psoriatic plaque which would result in clinical improvement.


Positive_regulation (components) of Gene_expression (production) of IL-40 in keratinocytes associated with psoriasis and apoptosis
4) Confidence 0.07 Published 2003 Journal BMC Dermatol Section Body Doc Link PMC169161 Disease Relevance 0.53 Pain Relevance 0.21
In a tertiary screen for IL-12p40 production by ELISA of supernatant levels from bone marrow-derived macrophages infected with these mutants, the mmaA3 mutant again showed increased IL-12p40 production.
Positive_regulation (increased) of Gene_expression (production) of IL-12p40 in macrophages
5) Confidence 0.06 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.32 Pain Relevance 0
Adoptive transfer of either IL-12p70– or IL-23–polarized T cells into naive syngeneic hosts resulted in an ascending paralysis that was clinically indistinguishable between the two groups.
Positive_regulation (transfer) of Gene_expression (transfer) of IL-12p70 in T cells associated with paralysis
6) Confidence 0.05 Published 2008 Journal The Journal of Experimental Medicine Section Abstract Doc Link PMC2442630 Disease Relevance 0.42 Pain Relevance 0.22
More importantly, 55°C-HIFU-treated tumor cells showed much more potent immunostimulatory activities than 80°C-HIFU-treated ones, both in the induction of IL-12p70 production and in the upregulation of CD80 and CD86 expression.
Positive_regulation (induction) of Gene_expression (production) of IL-12p70 in CD86 associated with cancer
7) Confidence 0.05 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.79 Pain Relevance 0.07
After HIFU-treatment, however, tumor cells became effective in inducing IL-12p70 production while their effects on IL-10 production markedly reduced.
Positive_regulation (inducing) of Gene_expression (production) of IL-12p70 associated with cancer
8) Confidence 0.05 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.65 Pain Relevance 0.04
Using a similar strategy to monitor IL-12p40 expression from a full-length (FL) IL-12p40 promoter [55], position ?
Positive_regulation (monitor) of Gene_expression (expression) of IL-12p40
9) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.23 Pain Relevance 0
Taken together, these data suggested that the TDM of wild type M. tuberculosis was a significant mediator of IL-12p40 repression in macrophages, whereas the TDMs of the ?
Positive_regulation (mediator) of Gene_expression (repression) of IL-12p40 in macrophages associated with mycobacterial infection and repression
10) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.33 Pain Relevance 0.06
Both the GFP expression of the reporter macrophage cell line and supernatant levels of IL-12p40 in primary macrophage cultures confirmed that the avirulent M. smegmatis strain was a robust inducer of IL-12p40 production.
Positive_regulation (inducer) of Gene_expression (production) of IL-12p40 in macrophage associated with sprains and strains
11) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.70 Pain Relevance 0.04
The findings of these investigators are consistent with our observation that wild type TDM induced low levels of IL-12p40 production by macrophages.
Positive_regulation (induced) of Gene_expression (production) of IL-12p40 in macrophages
12) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.21 Pain Relevance 0
This identified a major role in IL-12p40 repression for the mmaA4 (methoxy mycolic acid synthase 4) gene, which encodes the methyl transferase that introduces oxygen-containing modifications of cell wall mycolic acids.
Positive_regulation (role) of Gene_expression (repression) of IL-12p40 associated with repression
13) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.61 Pain Relevance 0.07
Mutants in which mmaA4 (hma) was inactivated stimulated macrophages to produce significantly more IL-12p40 and TNF-?
Positive_regulation (stimulated) of Gene_expression (produce) of IL-12p40 in macrophages
14) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2390761 Disease Relevance 0.70 Pain Relevance 0
In a tertiary screen for IL-12p40 production by ELISA of supernatant levels from bone marrow-derived macrophages infected with these mutants, the mmaA3 mutant again showed increased IL-12p40 production.
Positive_regulation (screen) of Gene_expression (production) of IL-12p40 in macrophages
15) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.21 Pain Relevance 0
mmaA4 TDM was also more directly stimulatory than wild type TDM with regard to activating macrophage production of IL-12p40.
Positive_regulation (activating) of Gene_expression (production) of IL-12p40 in macrophage
16) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.06 Pain Relevance 0
This analysis showed that TDMs from both sources reduced the LPS-induced IL-12p40 response, but that wild type TDM was significantly more potent in this regard than was ?
Positive_regulation (induced) of Gene_expression (response) of IL-12p40
17) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.33 Pain Relevance 0.13
Raw 264.7 cells were stably transfected with pFL.IL-12p40.EGFP-1 using electroporation, as described previously [25].
Positive_regulation (transfected) of Gene_expression (transfected) of IL-12p40
18) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.31 Pain Relevance 0
Since LPS signals mainly through the TLR4 receptor and wild type TDM bioactivity has been found to be independent of TLR4 signaling, it is unlikely that inhibition of LPS-mediated IL-12p40 production resulted from competition between wild type TDM and LPS for the TLR4 receptor [41].
Positive_regulation (resulted) of Gene_expression (production) of IL-12p40
19) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.07 Pain Relevance 0
This was evident in the ability of wild type TDM to significantly dampen LPS-induced IL-12p40 production.
Positive_regulation (induced) of Gene_expression (production) of IL-12p40
20) Confidence 0.05 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2390761 Disease Relevance 0.13 Pain Relevance 0

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