INT133175

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.31
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Scd2) endoplasmic reticulum (Scd2) lipid metabolic process (Scd2)
Anatomy Link Frequency
bone marrow 1
Scd2 (Mus musculus)
Pain Link Frequency Relevance Heat
Delta-9-tetrahydrocannabinol 9 100.00 Very High Very High Very High
Cannabinoid receptor 4 99.92 Very High Very High Very High
qutenza 2 99.34 Very High Very High Very High
cytokine 5 82.48 Quite High
Endocannabinoid 1 80.00 Quite High
Cannabinoid 2 73.80 Quite High
antagonist 2 57.48 Quite High
Paracetamol 2 25.84 Quite Low
Inflammation 4 25.20 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 2 92.24 High High
Infection 1 84.32 Quite High
Bordatella Infection 1 69.76 Quite High
Targeted Disruption 3 60.76 Quite High
INFLAMMATION 4 25.20 Quite Low
Stress 14 24.16 Low Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Hyperinsulinism 2 5.00 Very Low Very Low Very Low
Metabolic Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ability of AA to cause down-regulation of Scd-2 and Abcg1 and the up-regulation of Ech1 and Angptl4 gene expression (Figure 3) would infer a decrease in synthesis of unsaturated fatty acids (Scd-2) and a decrease in cholesterol transport to HDL (high-density lipoprotein) (Abcg1).
Negative_regulation (down-regulation) of Scd-2 associated with disorder of lipid metabolism
1) Confidence 0.11 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0.09 Pain Relevance 0
The down-regulation of Scd-2 (stearoyl-CoA desaturase) and Abcg1 (ATP-binding cassette subfamily G member 1) observed using microarray analysis was confirmed using real-time PCR (Figures 3A and 3B).
Negative_regulation (down-regulation) of Scd-2
2) Confidence 0.09 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2990202 Disease Relevance 0 Pain Relevance 0
Role of cannabinoid receptors in Delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila.
Negative_regulation (suppression) of Delta-9-tetrahydrocannabinol in bone marrow associated with qutenza, cannabinoid receptor and delta-9-tetrahydrocannabinol
3) Confidence 0.01 Published 2006 Journal Eur. J. Pharmacol. Section Title Doc Link 16443217 Disease Relevance 0.21 Pain Relevance 0.93

General Comments

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