INT133193

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 6.43
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT)
RNA binding (TERT) chromosome (TERT) nucleolus (TERT)
Anatomy Link Frequency
telomere 5
mononuclear cells 1
TERT (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 282 94.32 High High
cINOD 8 93.28 High High
agonist 24 86.52 High High
Chronic pancreatitis 3 83.28 Quite High
Inflammation 255 69.68 Quite High
Potency 8 65.36 Quite High
COX2 4 25.00 Low Low
aspirin 2 25.00 Low Low
cytokine 135 5.00 Very Low Very Low Very Low
chemokine 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 6 99.92 Very High Very High Very High
Cancer 274 99.12 Very High Very High Very High
Repression 24 98.88 Very High Very High Very High
Carcinoma In Situ 3 98.56 Very High Very High Very High
Carcinoma 3 98.50 Very High Very High Very High
Hepatitis 6 98.00 Very High Very High Very High
Papillomavirus Infection 6 97.44 Very High Very High Very High
Keloid Scars 515 94.52 High High
Adenoma 3 90.92 High High
Pancreatitis 3 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human telomerase reverse transcriptase (hTERT) is a subunit of telomerase that is essential for telomerase activity.
Positive_regulation (essential) of telomerase
1) Confidence 0.50 Published 2006 Journal Cancer Section Abstract Doc Link 16444744 Disease Relevance 0.24 Pain Relevance 0.09
BACKGROUND: Telomerase activation, which is observed in most human cancers, plays an important role in carcinogenesis.
Positive_regulation (activation) of Telomerase associated with cancer
2) Confidence 0.50 Published 2006 Journal Cancer Section Abstract Doc Link 16444744 Disease Relevance 0.25 Pain Relevance 0.08
Progressive telomere shortening predominantly occurs during early IPMNs carcinogenesis before telomerase activation and progression from borderline to carcinoma in situ IPMNs is the critical stage of IPMNs carcinogenesis at which telomere dysfunction occurs.
Positive_regulation (activation) of telomerase in telomere associated with carcinoma in situ
3) Confidence 0.47 Published 2008 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17960465 Disease Relevance 1.03 Pain Relevance 0.07
Telomerase activation in response to telomere crisis followed by telomere shortening is thought to be a crucial event in the development of most human cancers.
Positive_regulation (activation) of Telomerase in telomere associated with cancer
4) Confidence 0.47 Published 2008 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17960465 Disease Relevance 0.80 Pain Relevance 0.06
They pointed out that although the TCs were envisaged to provide surgical care in rural hospitals, a noticeable proportion of TCs are deployed at provincial and central hospitals, that the TC's work at district level greatly alleviates the pressure and workload of second and third referrals units:

"Well, our TC is good, because without him I don't know what would be in terms of the rural hospital [where] he is the surgeon; here in the provincial hospital he works in shifts in equal terms with the other specialists [surgeon, obstetrician and orthopaedic]; when one specialist goes on vacation, she/he is replaced by the TC.

Positive_regulation (proportion) of TCs
5) Confidence 0.44 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0.05 Pain Relevance 0
Besides this, the general opinion was that Rural Hospitals are almost completely dependent on TCs for surgical activity, for which they have adequate and usually appropriate training.
Positive_regulation (dependent) of TCs
6) Confidence 0.44 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0 Pain Relevance 0
Marked telomere shortening was observed from the in situ IPMN carcinoma stage (P<0.001; vs borderline IPMNs) through the invasive stage, although telomerase had been activated, indicating that telomeres had shortened to a critical length by this histological grade.
Positive_regulation (activated) of telomerase in telomeres associated with cancer and carcinoma
7) Confidence 0.41 Published 2008 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17960465 Disease Relevance 1.33 Pain Relevance 0.08
activation and hTERT gene transcription.
Positive_regulation (activation) of hTERT
8) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.15 Pain Relevance 0.34
Substantial data have implicated c-myc in the upregulation of hTERT transcription [7].
Positive_regulation (upregulation) of hTERT
9) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
Further, some studies suggest that methylation of the promoter of hTERT gene may contribute to the repression of hTERT gene transcription in some cell types [12].
Positive_regulation (methylation) of hTERT associated with repression
10) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.66 Pain Relevance 0
The proliferation-associated signal pathway with a high level of TERT activity and conserved telomere length occurring in Oct4/ATSCs and their gene expression revealed a reversion toward a more immature phenotype.
Positive_regulation (occurring) of TERT in telomere
11) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.27 Pain Relevance 0
The hTERT transcript levels increased by about 9.3 fold as compared to the levels in control cells after 4 hours of 25OH-C treatment (Figure 5).
Positive_regulation (increased) of hTERT
12) Confidence 0.19 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
The exposure of PBMCs to PMA resulted in a gradual increase in mRNA levels of hTERT, c-myc and PPAR?
Positive_regulation (increase) of hTERT
13) Confidence 0.19 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.05 Pain Relevance 0.40
The Oct4-overexpressed ATSC cells showed prominent effects on upregulation of a variety of proliferation-associated genes, including RUNX3, CDK2 and CDK4, and telomere reverse transcriptase (TERT; Fig. 1D).
Positive_regulation (upregulation) of TERT in telomere
14) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.13 Pain Relevance 0.03
Taken together, the findings of this study present evidence for a molecular link between cholesterol-activated Receptor Ck and hTERT transcription, and provide new insights into the regulation of hTERT expression in normal human peripheral blood mononuclear cells.



Positive_regulation (activated) of hTERT in mononuclear cells
15) Confidence 0.08 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.05 Pain Relevance 0.13
KPCs expressed relatively higher levels of Oct-4, Rex-1, Nanog, and human telomerase reverse transcriptase (hTERT) mRNAs than SKPs (Figure 1F).
Positive_regulation (levels) of telomerase reverse transcriptase
16) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.15 Pain Relevance 0
KPCs expressed relatively higher levels of Oct-4, Rex-1, Nanog, and human telomerase reverse transcriptase (hTERT) mRNAs than SKPs (Figure 1F).
Positive_regulation (levels) of hTERT
17) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.15 Pain Relevance 0
Meanwhile, we demonstrated that transplants generated from KPCs and SKPs in the presence of IL-6 expressed higher levels of Oct-4 and hTERT, as well as an elevated hTERT enzyme activity, as compared to control (Figures 6E, 6F and 6G).
Positive_regulation (elevated) of hTERT
18) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.37 Pain Relevance 0.03
Meanwhile, we demonstrated that transplants generated from KPCs and SKPs in the presence of IL-6 expressed higher levels of Oct-4 and hTERT, as well as an elevated hTERT enzyme activity, as compared to control (Figures 6E, 6F and 6G).
Positive_regulation (levels) of hTERT
19) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.37 Pain Relevance 0.03
Meanwhile, we demonstrated that transplants generated from KPCs and SKPs in the presence of IL-6 expressed higher levels of Oct-4 and hTERT, as well as an elevated hTERT enzyme activity, as compared to control (Figures 6E, 6F and 6G).
Positive_regulation (elevated) of hTERT
20) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.37 Pain Relevance 0.03

General Comments

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