INT133194

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 4.01
Pain Relevance 2.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT)
RNA binding (TERT) chromosome (TERT) nucleolus (TERT)
Anatomy Link Frequency
colon 2
SW1116 1
telomere 1
TERT (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 14 100.00 Very High Very High Very High
aspirin 7 100.00 Very High Very High Very High
cINOD 20 99.72 Very High Very High Very High
Kinase C 611 99.06 Very High Very High Very High
agonist 52 76.64 Quite High
fibrosis 80 74.56 Quite High
Inflammation 61 50.00 Quite Low
cytokine 27 5.00 Very Low Very Low Very Low
Central nervous system 13 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 52 100.00 Very High Very High Very High
INFLAMMATION 91 99.44 Very High Very High Very High
Cervical Cancer 13 99.12 Very High Very High Very High
Colon Cancer 21 97.40 Very High Very High Very High
Targeted Disruption 28 95.72 Very High Very High Very High
Cancer 299 94.52 High High
Papillomavirus Infection 13 91.52 High High
Hepatitis 32 89.52 High High
Sprains And Strains 2 88.60 High High
Apoptosis 45 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All the new mutations (R631Q, R671W, V867M, H925Q, R951W and G1063S) have not been identified previously and demonstrate reduced in vitro telomerase activity as measured by the telomere repeat amplication protocol (TRAP) assay (Figure S1).
Negative_regulation (reduced) of telomerase in telomere
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2873288 Disease Relevance 0.21 Pain Relevance 0.07
NSAIDs inhibited hTERT mRNA and protein expression through suppression of hTERT transcriptional activity.
Negative_regulation (suppression) of hTERT
2) Confidence 0.42 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.06 Pain Relevance 0
Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma.
Negative_regulation (Inhibition) of telomerase in colon associated with aspirin, inflammation and colon cancer
3) Confidence 0.42 Published 2006 Journal Cancer Section Title Doc Link 16444744 Disease Relevance 0.29 Pain Relevance 0.23
CONCLUSION: NSAIDs inhibit telomerase activity at hTERT transcriptional, mRNA, and protein levels in colon carcinoma cells.
Negative_regulation (inhibit) of telomerase in colon
4) Confidence 0.42 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.05 Pain Relevance 0
The aim of the study was to investigate whether nonsteroidal antiinflammatory drugs (NSAIDs) inhibit telomerase activity and hTERT.
Spec (whether) Negative_regulation (inhibit) of hTERT associated with inflammation and cinod
5) Confidence 0.42 Published 2006 Journal Cancer Section Abstract Doc Link 16444744 Disease Relevance 0.34 Pain Relevance 0.10
The aim of the study was to investigate whether nonsteroidal antiinflammatory drugs (NSAIDs) inhibit telomerase activity and hTERT.
Spec (whether) Negative_regulation (inhibit) of telomerase associated with inflammation and cinod
6) Confidence 0.42 Published 2006 Journal Cancer Section Abstract Doc Link 16444744 Disease Relevance 0.34 Pain Relevance 0.10
NSAIDs inhibited hTERT mRNA and protein expression through suppression of hTERT transcriptional activity.
Negative_regulation (inhibited) of hTERT
7) Confidence 0.42 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.06 Pain Relevance 0
Moreover, the three provinces were chosen because they have the largest number of TCs and rural hospitals in their respective region.
Negative_regulation (number) of TCs
8) Confidence 0.37 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0 Pain Relevance 0
According to current studies, these divergences may be attributed to absence of a cis-acting element repressing TERT promoter activity in murine cells [19].
Negative_regulation (repressing) of TERT
9) Confidence 0.32 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.28 Pain Relevance 0
RESULTS: Aspirin, indomethacin, and SC-236 inhibited telomerase activity in HT-29, COLO205, and CRL-2134 cell lines, but not in the SW1116 cell line.
Negative_regulation (inhibited) of telomerase in SW1116
10) Confidence 0.31 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.07 Pain Relevance 0
As control, copy numbers of TERT (Telomerase Reverse Transcriptase) and RPP21 (RNaseP protein p21) genes were assessed on the same DNA samples and two copies were always found (data not shown).
Negative_regulation (numbers) of TERT
11) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 0.53 Pain Relevance 0
The addition of PMA abolished the decrease in hTERT, c-myc and PPAR?
Negative_regulation (decrease) of hTERT
12) Confidence 0.24 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.11 Pain Relevance 0.34
Due to the negative regulation of the c-myc mRNA expression by 25OH-C, the addition of 25OH-C to this culture system was expected to further decrease c-myc and hTERT mRNA levels while not affecting the decline of PPAR?
Negative_regulation (decrease) of hTERT mRNA
13) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
The observation that the addition of 25OH-C to PBMCs cultured in medium enriched with 10% NHS is able to disrupt the Receptor Ck dependent down-regulation of hTERT, c-myc and PPAR?
Negative_regulation (regulation) of hTERT
14) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
These observations, which suggest a role for the oxygenated derivative of cholesterol in the regulation of hTERT gene transcription and more importantly, reveal the ability of 25OH-C to reverse the Receptor Ck dependent transcriptional repression of hTERT, c-myc and PPAR?
Negative_regulation (repression) of hTERT associated with repression
15) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.30 Pain Relevance 0.19
While cyclin D protein was expressed at only 4 hours and Bcl-2 protein was not expressed at all (Figure 3C), the level of hTERT mRNA gradually decreased over 12 hours (Figure 3B).
Negative_regulation (decreased) of hTERT mRNA
16) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
In the cells exposed to growth medium containing 10% NHS alone, Receptor Ck was activated by the cholesterol moiety of low density lipoprotein (LDL) supplied by 10% NHS and a decrease in the mRNA levels of hTERT, c-myc and PPAR?
Negative_regulation (decrease) of hTERT
17) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.11 Pain Relevance 0
Addition of 25OH-C transiently abolished the Receptor Ck dependent transcriptional down-regulation of hTERT, c-myc and PPAR?
Negative_regulation (regulation) of hTERT
18) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
and hTERT mRNA slightly decreased over 8 hours (Figure 9).
Negative_regulation (decreased) of hTERT mRNA
19) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.28
The observation that PKC activation by PMA is able to reverse the Receptor Ck dependent transcriptional down-regulation of hTERT, c-myc and PPAR?
Negative_regulation (regulation) of hTERT associated with kinase c
20) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0.39

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