INT133195

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 14
Disease Relevance 2.90
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT)
RNA binding (TERT) chromosome (TERT) nucleolus (TERT)
Anatomy Link Frequency
colon 4
somatic cells 2
TERT (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 517 99.80 Very High Very High Very High
agonist 44 92.00 High High
Central nervous system 11 45.04 Quite Low
COX2 6 10.00 Low Low
aspirin 3 10.00 Low Low
cINOD 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 44 100.00 Very High Very High Very High
Cancer 179 98.64 Very High Very High Very High
Hepatitis 11 96.76 Very High Very High Very High
Papillomavirus Infection 11 96.20 Very High Very High Very High
Targeted Disruption 22 95.72 Very High Very High Very High
Cervical Cancer 11 95.36 Very High Very High Very High
Apoptosis 33 77.76 Quite High
INFLAMMATION 17 64.48 Quite High
Hyperplasia 11 63.76 Quite High
Colon Cancer 14 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: NSAIDs inhibit telomerase activity at hTERT transcriptional, mRNA, and protein levels in colon carcinoma cells.
Negative_regulation (inhibit) of Transcription (transcriptional) of hTERT in colon
1) Confidence 0.42 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.05 Pain Relevance 0
NSAIDs inhibited hTERT mRNA and protein expression through suppression of hTERT transcriptional activity.
Negative_regulation (inhibited) of Transcription (expression) of hTERT
2) Confidence 0.31 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.06 Pain Relevance 0
CONCLUSION: NSAIDs inhibit telomerase activity at hTERT transcriptional, mRNA, and protein levels in colon carcinoma cells.
Negative_regulation (inhibit) of Transcription (transcriptional) of telomerase in colon
3) Confidence 0.31 Published 2006 Journal Cancer Section Body Doc Link 16444744 Disease Relevance 0.05 Pain Relevance 0
Consistent with this, the results of the present study also suggest the involvement of PKC inhibition in the down-regulation of hTERT gene transcription and PKC activation in the upregulation of hTERT gene transcription.
Negative_regulation (regulation) of Transcription (transcription) of hTERT associated with kinase c
4) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.10 Pain Relevance 0.48
In the present study, since Receptor Ck activation has been found to down-regulate hTERT transcription, it is expected to repress telomerase activity as well, because the enzymatic activity of telomerase can not possibly occur in the absence of hTERT, the catalytic subunit of telomerase.
Negative_regulation (regulate) of Transcription (transcription) of hTERT
5) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.26 Pain Relevance 0
Although several activators and repressors of hTERT gene transcription have been identified, the exact mechanism by which hTERT transcription is repressed in normal cells and activated in cancer cells remains largely unknown.
Negative_regulation (repressed) of Transcription (transcription) of hTERT associated with cancer
6) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.10 Pain Relevance 0
The Receptor Ck dependent down-regulation of hTERT transcription observed in normal human PBMCs may reflect a general mechanism for the repression of hTERT and telomerase expression in normal somatic cells.
Negative_regulation (down) of Transcription (transcription) of hTERT in somatic cells associated with repression
7) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.17 Pain Relevance 0.20
Although several activators and repressors of hTERT gene transcription have been identified, the exact mechanism by which hTERT transcription is repressed in normal cells and activated in cancer cells remains largely unknown.
Negative_regulation (repressors) of Transcription (transcription) of hTERT associated with cancer
8) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.10 Pain Relevance 0
By using specific activator and inhibitor of protein kinase C (PKC), it was demonstrated that Receptor Ck dependent down-regulation of hTERT gene transcription involved inhibition of PKC.
Negative_regulation (down) of Transcription (transcription) of hTERT associated with kinase c
9) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Abstract Doc Link PMC1351175 Disease Relevance 0.07 Pain Relevance 0.15
It is likely that as yet unidentified factors are important players in the control of activation and repression of hTERT transcription.
Negative_regulation (repression) of Transcription (transcription) of hTERT associated with repression
10) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.45 Pain Relevance 0
In order to determine whether or not c-myc mediates the Receptor Ck dependent down-regulation of hTERT gene transcription, normal human PBMCs cultured in medium containing 10% NHS were exposed to antibody against Receptor Ck along with 1 ?
Spec (whether) Negative_regulation (regulation) of Transcription (transcription) of hTERT
11) Confidence 0.18 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0 Pain Relevance 0
as a negative regulator of hTERT transcription.


Negative_regulation (regulator) of Transcription (transcription) of hTERT
12) Confidence 0.17 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.18 Pain Relevance 0.25
Further, some studies suggest that methylation of the promoter of hTERT gene may contribute to the repression of hTERT gene transcription in some cell types [12].
Negative_regulation (repression) of Transcription (transcription) of hTERT associated with repression
13) Confidence 0.17 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.65 Pain Relevance 0
Further, some studies suggest that methylation of the promoter of hTERT gene may contribute to the repression of hTERT gene transcription in some cell types [12].
Negative_regulation (repression) of Transcription (transcription) of hTERT associated with repression
14) Confidence 0.17 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.66 Pain Relevance 0

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