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Context Info
Confidence 0.56
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 4.64
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)
Anatomy Link Frequency
plasma 1
neurons 1
pituitary 1
forebrain 1
cortex 1
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 14 99.88 Very High Very High Very High
Morphine 7 99.44 Very High Very High Very High
ischemia 4 99.44 Very High Very High Very High
antidepressant 16 99.14 Very High Very High Very High
Opioid 6 99.04 Very High Very High Very High
Buprenorphine 6 98.04 Very High Very High Very High
Equianalgesic 1 94.84 High High
depression 17 93.52 High High
opioid receptor 4 89.92 High High
agonist 27 88.64 High High
Disease Link Frequency Relevance Heat
Stress 143 100.00 Very High Very High Very High
Cv Unclassified Under Development 3 99.44 Very High Very High Very High
Metastasis 4 99.00 Very High Very High Very High
Skin Cancer 5 98.80 Very High Very High Very High
Anxiety Disorder 13 96.64 Very High Very High Very High
Congenital Anomalies 2 95.28 Very High Very High Very High
Depression 26 93.52 High High
Nutritional Deficiencies 1 93.12 High High
Post-traumatic Stress Disorder 32 92.92 High High
Cancer 24 92.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
K-opioid substances have been shown to stimulate and/or depress the HPA activity.
Negative_regulation (depress) of HPA associated with opioid
1) Confidence 0.56 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1665898 Disease Relevance 0 Pain Relevance 0.25
Specifically, manipulations that increase or decrease HPA activity also increase or decrease drug intake, respectively.
Negative_regulation (decrease) of HPA
2) Confidence 0.56 Published 2006 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 17016707 Disease Relevance 0.15 Pain Relevance 0.07
PI-88, a potent inhibitor of heparanase, demonstrates anitangiogenic properties and has shown activity against melanoma in phase I studies.
Negative_regulation (inhibitor) of heparanase associated with skin cancer
3) Confidence 0.36 Published 2008 Journal Invest New Drugs Section Abstract Doc Link 17891338 Disease Relevance 0.36 Pain Relevance 0
Naloxone also attenuated the exaggeration in stress-induced HPA activity but did not affect the increases in plasma ACTH concentration which followed adrenalectomy.
Negative_regulation (attenuated) of HPA in plasma associated with stress and narcan
4) Confidence 0.32 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3010154 Disease Relevance 0.29 Pain Relevance 0.33
In normal animals morphine and fentanyl stimulate the HPA axis, decrease NK activity and augment tumor metastasis, while buprenorphine is devoid of these effects.
Negative_regulation (decrease) of HPA associated with metastasis, buprenorphine and morphine
5) Confidence 0.26 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17291715 Disease Relevance 0.59 Pain Relevance 1.05
In previous investigations, we have demonstrated that cholinesterase inhibitors such as physostigmine (PHY) and heptylphysostigmine (HEP) elicit a significant and simultaneous increase in acetylcholine (ACh) and norepinephrine (NE) levels in the rat cortex.
Negative_regulation (inhibitors) of HEP in cortex
6) Confidence 0.25 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562554 Disease Relevance 0 Pain Relevance 0.39
Results showed that ischemia stimulates but reperfusion suppresses the activity of HPA axis.
Negative_regulation (suppresses) of HPA associated with ischemia
7) Confidence 0.21 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12951192 Disease Relevance 0.34 Pain Relevance 0.50
Substantial information from these forebrain regions are integrated in the BNST that could either excite or inhibit HPA activity depending on the region of the BNST targeted [6].
Negative_regulation (inhibit) of HPA in forebrain
8) Confidence 0.18 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2887770 Disease Relevance 1.26 Pain Relevance 0.30
Antidepressants increase expression of hippocampal MR and decrease basal and stress-induced HPA activity.
Negative_regulation (decrease) of HPA associated with stress and antidepressant
9) Confidence 0.14 Published 2008 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2532603 Disease Relevance 1.11 Pain Relevance 0.18
These electrophysiological data suggest that the decreases in HPA activity evoked by IFN-alpha are mediated by a rapid inhibitory effect at the level of the corticotropin-releasing factor-secreting neurons.
Negative_regulation (decreases) of HPA in neurons
10) Confidence 0.11 Published 1994 Journal Brain Behav. Immun. Section Abstract Doc Link 8003770 Disease Relevance 0.07 Pain Relevance 0.31
At the pituitary level, the negative interrelation of the HPA and HPG axis may be mediated by the paracrine negative signals of ?
Negative_regulation (interrelation) of HPA in pituitary
11) Confidence 0.04 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0.48 Pain Relevance 0

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