INT133210

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2011
Negated 1
Speculated 4
Reported most in Body
Documents 33
Total Number 37
Disease Relevance 18.25
Pain Relevance 10.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Runx1) DNA binding (Runx1) transcription factor binding (Runx1)
Anatomy Link Frequency
stem cells 3
sensory neuron 2
sciatic nerve 2
nociceptor 2
neuronal 1
Runx1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 406 100.00 Very High Very High Very High
Pain 75 100.00 Very High Very High Very High
Neuropathic pain 556 99.32 Very High Very High Very High
TRP channel 4 97.20 Very High Very High Very High
withdrawal 185 96.52 Very High Very High Very High
Nav1.9 1 96.44 Very High Very High Very High
Sciatic nerve 100 96.24 Very High Very High Very High
nav1.8 9 95.72 Very High Very High Very High
Eae 115 95.68 Very High Very High Very High
tetrodotoxin-resistant sodium channels 1 95.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Myeloid Leukemia 460 100.00 Very High Very High Very High
Nociception 61 100.00 Very High Very High Very High
Targeted Disruption 411 99.78 Very High Very High Very High
Neuropathic Pain 615 99.32 Very High Very High Very High
Hypersensitivity 119 98.76 Very High Very High Very High
Megacolon 138 98.48 Very High Very High Very High
Pain 87 97.40 Very High Very High Very High
Recurrence 15 97.12 Very High Very High Very High
Injury 283 96.72 Very High Very High Very High
Nervous System Injury 70 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, after activation of Runx1a in bNCSCs we noted predominant differentiation along the glial lineage.
Positive_regulation (activation) of Runx1a
1) Confidence 0.69 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.16 Pain Relevance 0
The activation of Runx1a was accompanied by the expression of enhanced green fluorescent protein (EGFP), which was activated through the internal ribosome entry site (IRES)-EGFP.


Positive_regulation (activation) of Runx1a in internal
2) Confidence 0.69 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.26 Pain Relevance 0.08
We can only suggest that the phenotype of the transgenic pups is a consequence of Runx1a activity, since Runx1a was induced specifically in Sox10-expressing cells during days 8–11, i.e. when NCSCs are actively migrating, and since the phenotypic changes were only observed in double transgenic Sox10-rtTA/TRE-Runx1a pups.
Positive_regulation (induced) of Runx1a associated with targeted disruption
3) Confidence 0.69 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.76 Pain Relevance 0.11
We therefore addressed the issue whether activation of Runx1a in adult mice would attenuate hypersensitivity to mechanical stimulation 2 weeks following a sciatic nerve chronic constriction injury (CCI), a well established model of neuropathic pain behavior (12,13).
Spec (whether) Positive_regulation (activation) of Runx1a in sciatic nerve associated with eae, injury, hypersensitivity, neuropathic pain and sciatic nerve
4) Confidence 0.69 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 1.19 Pain Relevance 0.49
These phenotypic characteristics suggest that ectopic transitory activation of Runx1a specifically in Sox10-expressing cells strongly interferes with normal NCSC migration and probably also their normal differentiation.
Positive_regulation (activation) of Runx1a
5) Confidence 0.69 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.33 Pain Relevance 0
This observation suggests that activation of Runx1a with DOX inhibits the activity of Runx1 long isoform activity, which, in turn, attenuates the development of CCI-induced neuropathic pain behavior.
Positive_regulation (activation) of Runx1a associated with eae and neuropathic pain
6) Confidence 0.69 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 1.43 Pain Relevance 0.90
For this purpose we have employed the Tet system (7) to conditionally activate Runx1a in Rosa26 or Sox10-expressing cells.
Positive_regulation (activate) of Runx1a
7) Confidence 0.69 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.30 Pain Relevance 0.16
Since our findings in the in vitro experiments indicate that Runx1a has effects of its own, postnatal activation of Runx1a may not act as just a functional inhibitor of Runx1 long isoform activity.
Positive_regulation (activation) of Runx1a
8) Confidence 0.69 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.90 Pain Relevance 0.64
Early Runx1 activity is necessary to establish the expression of these genes [14,24], but subsequent Runx1 extinguishment is required to maintain these neurons (Fig. 4).
Positive_regulation (necessary) of Runx1 in neurons
9) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0 Pain Relevance 0.55
To verify the validity of EYFP expression as a measure of Runx1 upregulation, the expression of Runx1 and EYFP in DOX-treated and nontreated cultures was assessed with RT-PCR.


Positive_regulation (upregulation) of Runx1
10) Confidence 0.63 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0 Pain Relevance 0
Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain.
Positive_regulation (required) of Runx1 in sensory neuron associated with nociception, nociceptor and neuropathic pain
11) Confidence 0.50 Published 2006 Journal Neuron Section Title Doc Link 16446141 Disease Relevance 0.52 Pain Relevance 0.90
The size of the litters was reduced in DOX-activated Sox10-rtTA/TRE-Runx1a animals.
Positive_regulation (activated) of Runx1a
12) Confidence 0.50 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.36 Pain Relevance 0.11
The reduction of neuronal differentiation could therefore be explained as a consequence of Runx1a-mediated functional inhibition of Runx1 activity.
Positive_regulation (consequence) of Runx1a in neuronal
13) Confidence 0.50 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.15 Pain Relevance 0
We can only suggest that the phenotype of the transgenic pups is a consequence of Runx1a activity, since Runx1a was induced specifically in Sox10-expressing cells during days 8–11, i.e. when NCSCs are actively migrating, and since the phenotypic changes were only observed in double transgenic Sox10-rtTA/TRE-Runx1a pups.
Positive_regulation (consequence) of Runx1a associated with targeted disruption
14) Confidence 0.50 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 0.65 Pain Relevance 0.05
Analysis of E-CKO mice showed that Runx1 is required for TRPV1high expression, but dispensable for TRPV1low expression [14].
Positive_regulation (required) of Runx1
15) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0 Pain Relevance 0.43
We reported previously that Runx1 is partially required for the expression of Ret and the ATP-gated channel P2X3 [14].
Positive_regulation (required) of Runx1
16) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.20 Pain Relevance 0.32
Many of the receptors and channels that mediate nociceptor function in the DRG are dependent on Runx1, while the sensory peptides are not [7].
Positive_regulation (dependent) of Runx1 in nociceptor associated with nociceptor
17) Confidence 0.47 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.36 Pain Relevance 1.11
In the neuropathic pain model, the threshold for mechanical sensitivity was markedly increased following activation of Runx1a.


Positive_regulation (activation) of Runx1a associated with neuropathic pain
18) Confidence 0.46 Published 2010 Journal Upsala Journal of Medical Sciences Section Abstract Doc Link PMC2853355 Disease Relevance 0.47 Pain Relevance 0.33
In our experiments after activation of Runx1a short isoform, the response to mechanical stimulation was similar to that previously described in Runx1-/- mice (16).
Positive_regulation (activation) of Runx1a
19) Confidence 0.46 Published 2010 Journal Upsala Journal of Medical Sciences Section Body Doc Link PMC2853355 Disease Relevance 1.13 Pain Relevance 0.83
We also examined whether DOX-induced activation of Runx1a in adult mice affects their sensitivity to mechanical stimulation following a constriction injury of the sciatic nerve.


Spec (whether) Positive_regulation (activation) of Runx1a in sciatic nerve associated with injury and sciatic nerve
20) Confidence 0.46 Published 2010 Journal Upsala Journal of Medical Sciences Section Abstract Doc Link PMC2853355 Disease Relevance 0.54 Pain Relevance 0.44

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